Hydroxypinacolone Retinoate
High RiskVitamin A derivative. Systemic retinoids are known teratogens, and topical retinoids are avoided during pregnancy due to class-wide risk and limited safety margins. Avoid use during pregnancy regardless of formulation.
Sources: EMA: Updated measures for pregnancy prevention during retinoid use https://www.ema.europa.eu/en/news/updated-measures-pregnancy-prevention-during-retinoid-use; FDA: Pregnancy and Lactation Labeling Rule https://www.fda.gov/drugs/labeling-information-drug-products/questions-and-answers-pregnancy-and-lactation-labeling-rule



