SKIN1004
SKIN1004 Madagascar Centella Ampoule
No known risks99/100
SKIN1004
Azelaic Acid 10 Ampoule
Some ingredients carry a low-risk flag. Read the formulation context before deciding.
27 of 27 ingredients rated
Is it suitable during pregnancy?
MamaSkin rates the recorded formula for SKIN1004 Azelaic Acid 10 Ampoule as Low risk (78/100). Review the ingredient context and any manual-review explanation before deciding.
Why this rating?
The recorded formula includes 2 ingredient entries with risk flags: Azelaic Acid (Low risk), Glycyrrhiza Glabra (Licorice) Root Extract (Low risk). These are ingredient-level flags; they do not replace the stored product assessment or account for every formulation detail.
27 of 27 ingredient entries on this page have a recorded score, evidence summary and source text. That describes documentation coverage, not proof that the finished formula has been clinically tested during pregnancy.
How we assess productsIngredient breakdown
The recorded formula, with evidence behind each rating. Unmatched ingredients are marked Not assessed in grey.
Ingredient ratings and evidence
Higher-risk flags first. Open an ingredient for evidence.
Azelaic Acid
Low risk
Azelaic acid is used topically for acne and pigmentation. MotherToBaby reports that ACOG lists OTC azelaic acid among ingredients that can be used during pregnancy if needed. Product information for 20% azelaic acid states that adequate controlled pregnancy studies are lacking, reports reassuring animal data and estimates about 3.6% absorption after a single topical dose. MamaSkin retains Low Risk while avoiding a categorical “pregnancy-safe” claim.
Sources: MotherToBaby: Topical Acne Treatments https://www.ncbi.nlm.nih.gov/books/NBK582985/, Skinoren 20% cream product information https://www.medicines.org.uk/emc/product/285/smpc
Glycyrrhiza Glabra (Licorice) Root Extract
Low risk
This parenthetical INCI form is licorice root extract. High oral glycyrrhizin exposure is discouraged during pregnancy, while cosmetic licorice extracts are used topically at much lower exposure. Low Risk keeps the exact label string consistent with MamaSkin's existing Glycyrrhiza glabra root-extract policy.
Sources: CIR: Final Report on the Safety Assessment of Licorice-Derived Ingredients https://cir-reports.cir-safety.org/view-attachment/?id=7c9aa17d-8c74-ec11-8943-0022482f06a6; existing MamaSkin Glycyrrhiza glabra root-extract policy.
Water
No known risks
Water (Aqua) is the standard purified water used as a cosmetic solvent. It has no pregnancy-specific risk in normal topical use.
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/Water, https://single-market-economy.ec.europa.eu/sectors/cosmetics/cosmetic-ingredient-database/cosing-glossary-ingredients_en
Hydroxypropyl Cyclodextrin
No known risks
A plant-derived carbohydrate polymer or modified starch used to thicken, stabilise or condition a formula. Cosmetic safety reviewers concluded that the supported plant polysaccharide gums and derivatives are safe in current practices of use and concentration. Loose powders should still be used without deliberately inhaling airborne particles.
Sources: CIR: Safety Assessment of Plant Polysaccharide Gums as Used in Cosmetics https://www.cir-safety.org/panelbook/safety-assessment-plant-polysaccharide-gums-used-cosmetics
Disodium Phosphate
No known risks
An inorganic phosphate salt used mainly to buffer or adjust the pH of a formula. Cosmetic safety reviewers concluded that phosphoric acid and its simple salts, including disodium phosphate, are safe in current cosmetic use when products are formulated to avoid irritation. No pregnancy-specific concern is identified for normal topical exposure.
Sources: CIR: Safety Assessment of Phosphoric Acid and Its Simple Salts https://cir-safety.org/supplementaldoc/safety-assessment-phosphoric-acid-and-simple-salts-used-cosmetics-0
Show all 27 ingredients
Pentylene Glycol
No known risks
Humectant and preservative booster. Considered safe for cosmetic use with low systemic exposure.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
Propanediol
No known risks
Solvent and humectant used to improve texture and ingredient solubility. Low systemic exposure expected from topical cosmetic use.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
Potassium Azeloyl Diglycinate
No known risks
Potassium Azeloyl Diglycinate is a water-soluble azelaic-acid and glycine derivative used for skin conditioning and tone support. The intact cosmetic ingredient is not the same as free azelaic acid, and no reproductive or developmental hazard signal was identified for normal topical cosmetic exposure.
Sources: European Commission CosIng ingredient inventory; published cosmetic literature on potassium azeloyl diglycinate and azelaic-acid derivatives. No ingredient-specific pregnancy studies were identified.
Maltodextrin
No known risks
Polysaccharide carrier and bulking agent used for texture and delivery support. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Safety Assessment of Polysaccharide Gums as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
Azelamide Mea
No known risks
Azelamide MEA: An assessed monoethanolamide. Use non-irritating formulas and avoid conditions that form N-nitroso compounds. It is not a diethanolamide or free ethanolamine. No pregnancy-specific harm has been identified for ordinary topical cosmetic use; direct human pregnancy data are limited. This assessment excludes ingestion, medicinal doses and deliberate inhalation.
Sources: https://www.cir-safety.org/sites/default/files/amides032012FAR.pdf,https://www.cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf
Panthenol
No known risks
Panthenol (pro-vitamin B5) is used for soothing and barrier support and is generally well tolerated, with no known pregnancy or breastfeeding concerns in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation
Butylene Glycol
No known risks
Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
1,2-Hexanediol
No known risks
1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.
Sources: CIR; EU/UK Cosmetics Regulation
Glycerin
No known risks
Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation
Ethylhexylglycerin
No known risks
Preservative booster and skin-conditioning agent. Considered safe for cosmetic use with low systemic exposure when used as intended.
Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)
Allantoin
No known risks
Allantoin is a soothing skin protectant commonly used to help reduce irritation and support comfort, with no known pregnancy or breastfeeding concerns in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation
Centella Asiatica Extract
No known risks
Botanical skin-conditioning ingredient used in soothing and barrier-support formulas. Reviewed cosmetic safety sources support current cosmetic use when formulated to be non-sensitising, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.
Sources: CIR: Safety Assessment of Centella asiatica-derived Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
Melia Azadirachta Leaf Extract
No known risks
Neem leaf extract is used topically for skin conditioning and antimicrobial support. Reproductive concerns reported for concentrated neem seed preparations, intrauterine exposure, or high oral doses do not establish a hazard from normal topical cosmetic exposure to a leaf extract.
Sources: PubMed: oral purified neem seed extracts in primates https://pubmed.ncbi.nlm.nih.gov/8773426/; PubMed: intrauterine neem oil in primates https://pubmed.ncbi.nlm.nih.gov/8143455/; European Commission CosIng ingredient inventory. No human pregnancy study of normal topical cosmetic leaf-extract use was identified.
Biosaccharide Gum-1
No known risks
Microbial polysaccharide used for film forming, soothing, and hydration support. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Safety Assessment of Microbial Polysaccharide Gums as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
Sodium Hyaluronate
No known risks
Sodium hyaluronate (hyaluronic acid salt) is used for hydration and cushioning, with very low systemic absorption from topical use and no known pregnancy or breastfeeding concerns at cosmetic concentrations.
Sources: CIR; EU/UK Cosmetics Regulation
Melia Azadirachta Flower Extract
No known risks
Neem flower extract is used as a botanical skin-conditioning ingredient. A high-dose oral rat study altered the oestrous cycle and ovulation but did not show anti-implantation, abortifacient, or teratogenic effects. That oral dose does not establish a hazard from normal topical cosmetic exposure.
Sources: PubMed: high-dose oral neem flower extract reproductive study in rats https://pubmed.ncbi.nlm.nih.gov/19357745/; European Commission CosIng ingredient inventory. No human pregnancy study of normal topical cosmetic use was identified.
Beta-Glucan
No known risks
Film-forming polysaccharide used for soothing and hydration support. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Safety Assessment of Microbial Polysaccharide Gums as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
Centella Asiatica Leaf Extract
No known risks
A leaf extract used in soothing and skin-conditioning formulas. Cosmetic safety reviewers concluded that Centella asiatica leaf extract is safe at current cosmetic exposure when products are formulated to be non-sensitising. The assessment considered systemic and reproductive findings reported at substantially higher oral exposures; these did not establish a pregnancy-specific concern for ordinary topical cosmetic use. Centella constituents can still cause contact sensitivity in some people.
Sources: CIR: Safety Assessment of Centella asiatica-Derived Ingredients as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-centella-asiatica-derived-ingredients-used-cosmetics-1
Phellinus Linteus Extract
No known risks
A mushroom-derived conditioning extract. No pregnancy-specific hazard was identified for normal topical exposure; source allergy remains possible.
Sources: European Commission CosIng; CIR biological-source ingredient framework; peer-reviewed fungal-extract literature.
Tocopherol
No known risks
Vitamin E antioxidant used to protect oils and support the skin barrier. Not associated with pregnancy-specific concerns at cosmetic exposure.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
Citric Acid
No known risks
pH adjuster used in small amounts to maintain product stability. Not associated with pregnancy-specific concerns.
Sources: Scientific Committee on Consumer Safety (EU); European cosmetics regulatory framework
Sodium Citrate
No known risks
Buffering and chelating ingredient used to control pH and formulation stability. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Safety Assessment of Citric Acid, Inorganic Citrate Salts, and Alkyl Citrate Esters as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
Full recorded ingredient list
Water, Azelaic Acid, Hydroxypropyl Cyclodextrin, Disodium Phosphate, Pentylene Glycol, Propanediol, Potassium Azeloyl Diglycinate, Maltodextrin, Azelamide Mea, Panthenol, Butylene Glycol, 1,2-Hexanediol, Glycerin, Ethylhexylglycerin, Allantoin, Centella Asiatica Extract, Melia Azadirachta Leaf Extract, Biosaccharide Gum-1, Sodium Hyaluronate, Melia Azadirachta Flower Extract, Beta-Glucan, Centella Asiatica Leaf Extract, Phellinus Linteus Extract, Tocopherol, Citric Acid, Sodium Citrate, Glycyrrhiza Glabra (Licorice) Root Extract
Ingredient ratings refreshed 1 October 2026. Formulas vary by market and can change. Always compare with your packaging.
Questions about this assessment
Why does SKIN1004 Azelaic Acid 10 Ampoule have a Low risk rating?
The recorded formula includes 2 ingredient entries with risk flags: Azelaic Acid (Low risk), Glycyrrhiza Glabra (Licorice) Root Extract (Low risk). These are ingredient-level flags; they do not replace the stored product assessment or account for every formulation detail. The product score is a stored assessment, not a clinical safety guarantee.
Is this assessment based only on the azelaic acid?
No. Azelaic Acid appears in the recorded ingredient list, but this page shows the finished product's stored assessment and the available ratings for its other ingredients too. An assessment of one headline ingredient does not establish the suitability of every formula containing it.
Has every ingredient in SKIN1004 Azelaic Acid 10 Ampoule been assessed?
27 of 27 ingredient entries on this page have a recorded score, evidence summary and source text. That describes documentation coverage, not proof that the finished formula has been clinically tested during pregnancy.
Does this assessment apply to my SKIN1004 Azelaic Acid 10 Ampoule?
Only if the ingredient list on your packaging matches the recorded formula shown here. Formulas can differ by market and change over time. Compare the full list, not just the product name; report a mismatch if it differs.
Does this pregnancy assessment also establish breastfeeding suitability?
No. This page presents a pregnancy-focused product assessment. Do not infer a breastfeeding conclusion from its score or label; breastfeeding requires a separate assessment of the formula and how it is used.
