SKIN1004
SKIN1004 Madagascar Centella Ampoule
No known risks99/100
SKIN1004
Madagascar Centella Poremizing Fresh Ampoule
Some ingredients carry a low-risk flag. Read the formulation context before deciding.
31 of 32 ingredients rated1 not assessed
Is it suitable during pregnancy?
MamaSkin rates the recorded formula for SKIN1004 Madagascar Centella Poremizing Fresh Ampoule as Low risk (79/100). Review the ingredient context and any manual-review explanation before deciding.
Why this rating? Manual-review explanation
Manual review 2026-07-13: The recorded formula was manually reviewed. This formula contains Dipotassium Glycyrrhizate, classified as low risk under MamaSkin's pregnancy-screening policy. This is a cautious classification, not a known pregnancy contraindication; see the highlighted ingredient entry for its rationale and sources.
31 of 32 ingredient entries on this page have a recorded score, evidence summary and source text. 1 entry does not have all of those fields. Unmatched or unrated entries are marked Not assessed in grey; missing evidence does not establish safety.
How we assess productsIngredient breakdown
The recorded formula, with evidence behind each rating. Unmatched ingredients are marked Not assessed in grey.
Ingredient ratings and evidence
Higher-risk flags first. Open an ingredient for evidence.
Dipotassium Glycyrrhizate
Low risk
A purified glycyrrhizic-acid salt used as a soothing and skin-conditioning ingredient. Cosmetic safety reviewers concluded that dipotassium glycyrrhizate is safe in current cosmetic use and noted poor dermal absorption. MamaSkin nevertheless applies a cautious low-risk classification for consistency with the existing licorice family because high oral glycyrrhizin exposure has pregnancy-related concerns; this is not a topical contraindication.
Sources: CIR: Safety Assessment of Glycyrrhizic Acid and Derivatives https://cir-reports.cir-safety.org/view-attachment/?id=49a63435-8e74-ec11-8943-0022482f06a6
Mineral Salts
Not assessed
No matched ingredient rating is available yet. Not assessed does not mean safe or unsafe.
Centella Asiatica Extract 50.47%
No known risks
Botanical skin-conditioning ingredient used in soothing and barrier-support formulas. Reviewed cosmetic safety sources support current cosmetic use when formulated to be non-sensitising, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.
Sources: CIR: Safety Assessment of Centella asiatica-derived Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
Water
No known risks
Water (Aqua) is the standard purified water used as a cosmetic solvent. It has no pregnancy-specific risk in normal topical use.
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/Water, https://single-market-economy.ec.europa.eu/sectors/cosmetics/cosmetic-ingredient-database/cosing-glossary-ingredients_en
Butylene Glycol
No known risks
Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
Show all 32 ingredients
Propanediol
No known risks
Solvent and humectant used to improve texture and ingredient solubility. Low systemic exposure expected from topical cosmetic use.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
1,2-Hexanediol
No known risks
1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.
Sources: CIR; EU/UK Cosmetics Regulation
Aloe Barbadensis Leaf Extract
No known risks
Botanical skin-conditioning ingredient used in soothing and hydrating formulas. Reviewed cosmetic safety sources support current cosmetic use provided anthraquinone levels do not exceed the limits addressed in the safety assessment; no pregnancy- or breastfeeding-specific topical concern was identified in the material reviewed.
Sources: CIR: Safety Assessment of Aloe-derived Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
Glycereth-26
No known risks
An ethoxylated glycerin humectant used to retain moisture and improve product texture. The Cosmetic Ingredient Review assessed glycerin ethoxylates including Glycereth-26 for current cosmetic use; available evidence does not identify a pregnancy- or breastfeeding-specific concern from normal topical exposure.
Sources: CIR: Safety Assessment of Glycerin Ethoxylates https://cir-safety.org/supplementaldoc/safety-assessment-glycerin-ethoxylates-used-cosmetics
Hydroxyacetophenone
No known risks
Hydroxyacetophenone is used as an antioxidant and preservative-support ingredient; it is generally considered low concern in topical cosmetic use with no known pregnancy or breastfeeding risks at typical concentrations.
Sources: CIR; EU/UK Cosmetics Regulation
Glycerin
No known risks
Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation
Carbomer
No known risks
Polymer thickener used to create gel textures. Large-molecule ingredient with negligible systemic absorption.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
Tromethamine
No known risks
pH adjuster and buffer used to stabilise formulations. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Safety Assessment of Tromethamine as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
Panthenol
No known risks
Panthenol (pro-vitamin B5) is used for soothing and barrier support and is generally well tolerated, with no known pregnancy or breastfeeding concerns in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation
Ethylhexylglycerin
No known risks
Preservative booster and skin-conditioning agent. Considered safe for cosmetic use with low systemic exposure when used as intended.
Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)
Disodium EDTA
No known risks
Disodium EDTA is a chelating agent used to improve formula stability and performance; it is considered low concern in topical cosmetic use, with no known pregnancy or breastfeeding risks at typical concentrations.
Sources: CIR; EU/UK Cosmetics Regulation
Ammonium Polyacryloyldimethyl Taurate
No known risks
A high-molecular-weight polymer used to thicken and stabilise formulas. Cosmetic safety reviewers concluded that acryloyldimethyltaurate polymers are safe in current cosmetic practices. Absorption of the finished polymer is expected to be limited, with residual monomers controlled during manufacture.
Sources: CIR: Safety Assessment of Acryloyldimethyltaurate Polymers as Used in Cosmetics; final report April 2017 https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf
Biosaccharide Gum-1
No known risks
Microbial polysaccharide used for film forming, soothing, and hydration support. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Safety Assessment of Microbial Polysaccharide Gums as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
Hyaluronic Acid
No known risks
High-water-binding humectant used to support hydration at the skin surface. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
Hydrolyzed Hyaluronic Acid
No known risks
Humectant and skin-conditioning ingredient in the hyaluronate family. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.
Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
Sodium Hyaluronate
No known risks
Sodium hyaluronate (hyaluronic acid salt) is used for hydration and cushioning, with very low systemic absorption from topical use and no known pregnancy or breastfeeding concerns at cosmetic concentrations.
Sources: CIR; EU/UK Cosmetics Regulation
Hydroxyethylcellulose
No known risks
Cellulose-derived thickener used to build viscosity and improve texture. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR Quick Reference Table / ingredient status (Hydroxyethylcellulose, Final Report 03/2009); EU CosIng / cosmetics regulatory inventory
Chamomilla Recutita Flower Extract
No known risks
A German chamomile flower extract used for skin conditioning and soothing. Cosmetic safety reviewers concluded that Chamomilla recutita flower-derived ingredients are safe in current cosmetic use when formulated to be non-sensitizing. Chamomile can cause contact allergy in susceptible people, particularly those sensitive to plants in the Asteraceae family, but no pregnancy-specific concern is identified for normal topical cosmetic exposure.
Sources: CIR: Safety Assessment of Chamomilla Recutita-Derived Ingredients as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-chamomilla-recutita-derived-ingredients-used-cosmetics-0
Tripeptide-3
No known risks
tripeptide-3 is an amino acid, peptide, protein-related or glycosaminoglycan cosmetic conditioning ingredient. Expected systemic exposure from normal topical use is low, and relevant cosmetic-family assessments did not identify a pregnancy-specific concern. Manufacturing quality and residual allergenic proteins remain relevant where applicable.
Sources: CIR assessments of alpha-amino acids, plant-derived amino acids, proteins and peptides https://www.cir-safety.org/supplementaldoc/safety-assessment-%CE%B1-amino-acids-used-cosmetics; European Commission CosIng
Acetyl Hexapeptide-8
No known risks
Synthetic peptide used as a skin-conditioning ingredient. Reviewed cosmetic safety sources do not indicate a known pregnancy- or breastfeeding-specific concern in normal topical cosmetic use. The available cosmetic safety assessment concluded this ingredient is safe in cosmetics at concentrations up to 0.005%; safety above that concentration was not established in the reviewed report.
Sources: CIR Expert Panel, Safety Assessment of Acetyl Hexapeptide-8 Amide as Used in Cosmetics, final report, 2021
Acetyl Octapeptide-3
No known risks
Synthetic acetylated peptide used in topical cosmetic anti-aging formulas, commonly as an expression-line peptide. Available cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.
Sources: Schagen SK. Topical Peptide Treatments with Effective Anti-Aging Results. Cosmetics. 2017;4(2):16. doi:10.3390/cosmetics4020016; EU CosIng / INCI cosmetic ingredient references.
Copper Tripeptide-1
No known risks
Copper-binding carrier peptide also known as GHK-Cu, used topically in cosmetic skin-renewal, anti-aging, barrier-support and hair/scalp products. Reviewed literature describes topical cosmetic use and does not identify a pregnancy- or breastfeeding-specific risk signal for normal topical use. This assessment does not apply to injectable copper peptides or oral peptide/copper supplementation.
Sources: Schagen SK. Topical Peptide Treatments with Effective Anti-Aging Results. Cosmetics. 2017;4(2):16. doi:10.3390/cosmetics4020016; Pickart L et al. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018;19(7):1987. doi:10.3390/ijms19071987.
Palmitoyl Pentapeptide-4
No known risks
Synthetic palmitoylated signal peptide used in topical anti-aging cosmetics. It is one of the better-studied cosmetic peptides, with reviewed topical literature describing controlled cosmetic studies and no pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.
Sources: Schagen SK. Topical Peptide Treatments with Effective Anti-Aging Results. Cosmetics. 2017;4(2):16. doi:10.3390/cosmetics4020016; Robinson LR et al. Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin. Int J Cosmet Sci. 2005;27(3):155-160.
Palmitoyl Tetrapeptide-7
No known risks
Synthetic signal peptide used in topical cosmetic anti-aging and skin-conditioning formulas. Reviewed topical peptide literature describes palmitoyl tetrapeptide-7 as a cosmetic peptide with anti-inflammatory and extracellular-matrix support activity in topical formulations. No pregnancy- or breastfeeding-specific risk signal was identified for normal topical cosmetic use.
Sources: Schagen SK. Topical Peptide Treatments with Effective Anti-Aging Results. Cosmetics. 2017;4(2):16. doi:10.3390/cosmetics4020016; CIR Expert Panel safety assessment of palmitoyl oligopeptides as used in cosmetics.
Palmitoyl Tripeptide-1
No known risks
Synthetic peptide used as a skin-conditioning ingredient. Reviewed cosmetic safety sources indicate no known pregnancy- or breastfeeding-specific concern in normal topical cosmetic use. Available cosmetic safety assessments conclude this ingredient is safe in the present practices of use and concentration described for cosmetics.
Sources: CIR Expert Panel, Safety Assessment of Tripeptide-1, Hexapeptide-12, their metal salts and fatty acyl derivatives, and Palmitoyl Tetrapeptide-7 as used in cosmetics, final report, 2014
Tripeptide-1
No known risks
Short synthetic peptide used as a skin-conditioning cosmetic ingredient. Cosmetic safety review sources for tripeptide-1 and related derivatives do not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.
Sources: CIR Expert Panel. Safety Assessment of Tripeptide-1, Hexapeptide-12, their metal salts and fatty acyl derivatives, and Palmitoyl Tetrapeptide-7 as used in cosmetics. Final report, 2014; Schagen 2017 doi:10.3390/cosmetics4020016.
Tripeptide-2
No known risks
tripeptide-2 is an amino acid, peptide, protein-related or glycosaminoglycan cosmetic conditioning ingredient. Expected systemic exposure from normal topical use is low, and relevant cosmetic-family assessments did not identify a pregnancy-specific concern. Manufacturing quality and residual allergenic proteins remain relevant where applicable.
Sources: CIR assessments of alpha-amino acids, plant-derived amino acids, proteins and peptides https://www.cir-safety.org/supplementaldoc/safety-assessment-%CE%B1-amino-acids-used-cosmetics; European Commission CosIng
Full recorded ingredient list
Centella Asiatica Extract 50.47%, Water, Butylene Glycol, Propanediol, 1,2-Hexanediol, Aloe Barbadensis Leaf Extract, Glycereth-26, Hydroxyacetophenone, Glycerin, Carbomer, Tromethamine, Panthenol, Ethylhexylglycerin, Disodium EDTA, Dipotassium Glycyrrhizate, Ammonium Polyacryloyldimethyl Taurate, Biosaccharide Gum-1, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Sodium Hyaluronate, Hydroxyethylcellulose, Chamomilla Recutita Flower Extract, Mineral Salts, Tripeptide-3, Acetyl Hexapeptide-8, Acetyl Octapeptide-3, Copper Tripeptide-1, Palmitoyl Pentapeptide-4, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Tripeptide-1, Tripeptide-2
Ingredient ratings refreshed 1 October 2026. Formulas vary by market and can change. Always compare with your packaging.
Questions about this assessment
Why does SKIN1004 Madagascar Centella Poremizing Fresh Ampoule have a Low risk rating?
Manual review 2026-07-13: The recorded formula was manually reviewed. This formula contains Dipotassium Glycyrrhizate, classified as low risk under MamaSkin's pregnancy-screening policy. This is a cautious classification, not a known pregnancy contraindication; see the highlighted ingredient entry for its rationale and sources. Incomplete ingredient documentation does not establish safety; see the coverage answer and grey entries below.
Is the licorice-derived ingredient the same as drinking licorice tea?
No. The recorded formula lists a licorice-derived cosmetic ingredient, not an oral licorice product. Different ingredients and routes of exposure should not be treated as interchangeable. Use the exact ingredient's rating and evidence below, together with any manual-review note; this score does not assess teas, supplements or other licorice formulas.
Has every ingredient in SKIN1004 Madagascar Centella Poremizing Fresh Ampoule been assessed?
31 of 32 ingredient entries on this page have a recorded score, evidence summary and source text. 1 entry does not have all of those fields. Unmatched or unrated entries are marked Not assessed in grey; missing evidence does not establish safety.
Does this assessment apply to my SKIN1004 Madagascar Centella Poremizing Fresh Ampoule?
Only if the ingredient list on your packaging matches the recorded formula shown here. Formulas can differ by market and change over time. Compare the full list, not just the product name; report a mismatch if it differs.
Does this pregnancy assessment also establish breastfeeding suitability?
No. This page presents a pregnancy-focused product assessment. Do not infer a breastfeeding conclusion from its score or label; breastfeeding requires a separate assessment of the formula and how it is used.
