Madagascar Centella Probio-Cica Essence Toner

Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

Solvent and humectant used to improve texture and ingredient solubility. Low systemic exposure expected from topical cosmetic use.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.

Sources: CIR; EU/UK Cosmetics Regulation

Polyglycerin fatty-acid ester used as an emulsifier and solubilizer. Reviewed cosmetic safety references do not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.

Sources: CIR cosmetic ingredient safety references for polyglyceryl fatty acid esters; EU CosIng / cosmetics regulatory inventory

Polymer thickener and stabiliser used in creams and sunscreens. Low systemic exposure expected.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Sugar-derived humectant used to help bind water and improve skin feel. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.

Sources: CIR: Safety Assessment of Monosaccharides, Disaccharides, and Related Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Panthenol (pro-vitamin B5) is used for soothing and barrier support and is generally well tolerated, with no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

Preservative booster and skin-conditioning agent. Considered safe for cosmetic use with low systemic exposure when used as intended.

Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)

Buffering and chelating ingredient used to control pH and formulation stability. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Citric Acid, Inorganic Citrate Salts, and Alkyl Citrate Esters as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Natural polysaccharide thickener used for stability and texture. Not associated with pregnancy-specific concerns.

Sources: European cosmetics regulatory framework

pH adjuster and buffer used to stabilise formulations. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Tromethamine as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Common emollient derived from fatty acids and glycerin. Used to soften skin and improve texture without pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Chelating agent used to improve formula stability. Used at low levels and not associated with pregnancy-specific concerns.

Sources: European cosmetics regulatory framework

pH adjuster used in small amounts to maintain product stability. Not associated with pregnancy-specific concerns.

Sources: Scientific Committee on Consumer Safety (EU); European cosmetics regulatory framework

Hydrogenated emulsifier used to support skin barrier feel. Not associated with pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US)

A polyglycerin fatty-acid ester used as an emulsifier, dispersant or emollient. Cosmetic safety reviewers concluded that the assessed family of 274 polyglyceryl fatty acid esters is safe in current practices when formulated to be non-irritating. No pregnancy-specific concern was identified for normal topical cosmetic exposure.

Sources: CIR: Safety Assessment of Polyglyceryl Fatty Acid Esters as Used in Cosmetics https://www.cir-safety.org/supplementaldoc/safety-assessment-polyglyceryl-fatty-acid-esters-used-cosmetics-1

Skin-identical barrier lipid used to support the stratum corneum and reduce dryness. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Ceramides as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Crosslinked hyaluronate humectant used to support hydration at the skin surface. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A sucrose-derived fatty ester used as an emulsifier and skin-conditioning ingredient. Related saccharide esters are supported for cosmetic use and have low expected systemic exposure. No pregnancy-specific hazard was identified for normal topical use.

Sources: CIR: Safety Assessment of Saccharide Esters as Used in Cosmetics; European Commission CosIng ingredient inventory.

A triterpene associated with Centella asiatica and used in soothing and skin-conditioning formulas. Pregnancy-specific evidence for isolated topical madecassic acid is limited. Evidence for the related Centella ingredient family supports current cosmetic exposure when products are formulated to avoid sensitisation; no pregnancy-specific topical contraindication was identified in the reviewed material.

Sources: CIR: Safety Assessment of Centella asiatica-Derived Ingredients as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-centella-asiatica-derived-ingredients-used-cosmetics-1

A triterpene glycoside associated with Centella asiatica and used in soothing and skin-conditioning formulas. Pregnancy-specific evidence for isolated topical asiaticoside is limited. Cosmetic safety reviewers considered Centella-derived ingredients acceptable at current cosmetic exposure but noted that asiaticoside and related triterpenes may contribute to sensitisation. No pregnancy-specific topical contraindication was identified in the reviewed material.

Sources: CIR: Safety Assessment of Centella asiatica-Derived Ingredients as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-centella-asiatica-derived-ingredients-used-cosmetics-1

Hydrolysed carbohydrate-rich skin components used for hydration and conditioning. Systemic exposure from topical cosmetic use is expected to be low, and no pregnancy-specific concern was identified. Source-dependent allergy remains possible.

Sources: European Commission CosIng ingredient inventory; peer-reviewed literature on topical glycosaminoglycans and cosmetic skin hydration.

This naturally occurring fatty acid is used for emolliency, cleansing support or texture. The Cosmetic Ingredient Review concluded that assessed fatty acids are safe in current cosmetic use when formulated to be non-irritating and non-sensitizing; some can increase penetration of other formula ingredients.

Sources: CIR: Safety Assessment of Fatty Acids and Fatty Acid Salts as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-fatty-acids-fatty-acid-salts-used-cosmetic

A triterpene associated with Centella asiatica and used in skin-conditioning formulas. Pregnancy-specific evidence for isolated topical asiatic acid is limited. Cosmetic safety reviewers considered Centella-derived ingredients acceptable at current cosmetic exposure but identified asiatic acid and related constituents as potential contributors to sensitisation. No pregnancy-specific topical contraindication was identified in the reviewed material.

Sources: CIR: Safety Assessment of Centella asiatica-Derived Ingredients as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-centella-asiatica-derived-ingredients-used-cosmetics-1

Plant-derived sterols used for skin conditioning and barrier support. The Cosmetic Ingredient Review concluded that phytosterols are safe in current cosmetic use and reported no maternal or teratogenic effects in reviewed oral data; normal topical exposure does not identify a pregnancy-specific concern.

Sources: CIR: Safety Assessment of Phytosterols https://www.cir-safety.org/supplementaldoc/safety-assessment-phytosterols-used-cosmetics-0

Sodium hyaluronate (hyaluronic acid salt) is used for hydration and cushioning, with very low systemic absorption from topical use and no known pregnancy or breastfeeding concerns at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Betaine is a humectant/osmolyte used to support hydration and reduce irritation potential in formulas; it is considered low concern with no known pregnancy or breastfeeding risks in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

A fatty acid used for cleansing, emollience or formula structure. Cosmetic safety reviewers concluded that caprylic acid and hydroxystearic acid are safe in current practices when formulated to be non-irritating and non-sensitising.

Sources: CIR: Fatty Acids final assessment, April 2019; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

A solvent or preservative-support ingredient used to dissolve actives and stabilise a formula. No reproductive or pregnancy-specific signal was identified for the low concentrations used in finished topical cosmetics. Solvents can still increase local irritation or the delivery of other formula ingredients.

Sources: European Commission CosIng ingredient inventory; European Chemicals Agency substance information; published dermal and cosmetic-use data for dimethyl isosorbide, phenylpropanol and benzyl glycol.

Humectant and skin-conditioning ingredient in the hyaluronate family. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

This plant-derived fatty oil or butter is used as an emollient and skin-conditioning ingredient. The Cosmetic Ingredient Review concluded that assessed plant-derived fatty acid oils are safe as used in cosmetics; individual plant allergy and ingredient purity remain practical considerations.

Sources: CIR: Safety Assessment of Plant-Derived Fatty Acid Oils https://cir-reports.cir-safety.org/view-attachment/?id=ad62ac6b-8e74-ec11-8943-0022482f06a6

High-water-binding humectant used to support hydration at the skin surface. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Raspberry ketone is used at low levels as a fragrance or skin-conditioning material. Concerns reported for high-dose oral supplements and screening models do not establish a reproductive hazard at normal topical cosmetic exposure. High local concentrations may stress melanocytes, so this assessment does not cover concentrated treatment use.

Sources: PubMed: high-dose food-supplement toxicology discussion https://pubmed.ncbi.nlm.nih.gov/26160596/; PubMed: in-vitro melanocyte effects https://pubmed.ncbi.nlm.nih.gov/26867644/; RIFM toxicological assessment of related fragrance ketones https://pubmed.ncbi.nlm.nih.gov/24246175/.

Skin-conditioning lipid used in barrier-support formulas, commonly alongside ceramides and cholesterol. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.

Sources: CIR cosmetic ingredient safety references for sphingolipids/skin-conditioning lipids; EU CosIng / cosmetics regulatory inventory