Tranexamic Acid
Low RiskSynthetic lysine analogue used topically for melasma and hyperpigmentation; inhibits plasmin activity and downstream melanogenesis. Topical formulations (≈2–5%) show low systemic absorption and no reported teratogenic effects, but pregnancy-specific data remain limited. Many sources regard it as pregnancy-safe or acceptable, while some advise cautious use or deferral until after pregnancy due to limited evidence.
Sources: PubMed: Topical tranexamic acid dermatology literature https://pubmed.ncbi.nlm.nih.gov/?term=topical+tranexamic+acid+melasma+safety



