SKIN1004
SKIN1004 Madagascar Centella Ampoule
No known risks99/100
Is it suitable during pregnancy?
MamaSkin rates the recorded formula for SKIN1004 Madagascar Centella Tone Brightening Capsule Ampoule as Low risk (76/100). Review the ingredient context and any manual-review explanation before deciding.
Why this rating?
The recorded formula includes 1 ingredient entry with a risk flag: tranexamic acid (Low risk). These are ingredient-level flags; they do not replace the stored product assessment or account for every formulation detail.
26 of 26 ingredient entries on this page have a recorded score, evidence summary and source text. That describes documentation coverage, not proof that the finished formula has been clinically tested during pregnancy.
How we assess productsIngredient breakdown
The recorded formula, with evidence behind each rating. Unmatched ingredients are marked Not assessed in grey.
Ingredient ratings and evidence
Higher-risk flags first. Open an ingredient for evidence.
tranexamic acid
Low risk
Synthetic lysine analogue used topically for melasma and hyperpigmentation; inhibits plasmin activity and downstream melanogenesis. Topical formulations (≈2–5%) show low systemic absorption and no reported teratogenic effects, but pregnancy-specific data remain limited. Many sources regard it as pregnancy-safe or acceptable, while some advise cautious use or deferral until after pregnancy due to limited evidence.
Sources: PubMed: Topical tranexamic acid dermatology literature https://pubmed.ncbi.nlm.nih.gov/?term=topical+tranexamic+acid+melasma+safety
1,2-hexanediol
No known risks
1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.
Sources: CIR; EU/UK Cosmetics Regulation
3-o-ethyl ascorbic acid
No known risks
A stable ether derivative of vitamin C used as an antioxidant and brightening ingredient. Pregnancy-specific topical studies are limited, but no pregnancy-specific contraindication was identified in the reviewed literature. Published case reports describe allergic contact dermatitis, so local sensitivity remains possible and this classification should not be read as proof that irritation cannot occur.
Sources: CIR: Safety Assessment of Ethers of Ascorbic Acid https://www.cir-safety.org/sites/default/files/ethers_of_ascorbate.pdf; PubMed: 3-O-ethyl-L-ascorbic acid topical delivery https://pubmed.ncbi.nlm.nih.gov/31517290/; PubMed: allergic contact dermatitis case report https://pubmed.ncbi.nlm.nih.gov/24846587/
acrylates/c10-30 alkyl acrylate crosspolymer
No known risks
Polymer thickener and stabiliser used in creams and sunscreens. Low systemic exposure expected.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
anhydroxylitol
No known risks
Sugar-derived humectant used to support hydration, often as part of saccharide blends. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Safety Assessment of Saccharide Humectants / Saccharide Isomerate, etc.; EU CosIng / cosmetics regulatory inventory
Show all 26 ingredients
arginine
No known risks
Amino acid used as a humectant, skin-conditioning agent, and pH-adjusting support ingredient. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Safety Assessment of α-Amino Acids as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
betaine
No known risks
Betaine is a humectant/osmolyte used to support hydration and reduce irritation potential in formulas; it is considered low concern with no known pregnancy or breastfeeding risks in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation
butylene glycol
No known risks
Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
centella asiatica extract
No known risks
Botanical skin-conditioning ingredient used in soothing and barrier-support formulas. Reviewed cosmetic safety sources support current cosmetic use when formulated to be non-sensitising, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.
Sources: CIR: Safety Assessment of Centella asiatica-derived Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
ethylhexylglycerin
No known risks
Preservative booster and skin-conditioning agent. Considered safe for cosmetic use with low systemic exposure when used as intended.
Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)
glucose
No known risks
Simple sugar used as a humectant and skin-conditioning support ingredient. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.
Sources: CIR: Safety Assessment of Monosaccharides, Disaccharides, and Related Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
glycerin
No known risks
Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation
hydrogenated lecithin
No known risks
Hydrogenated emulsifier used to support skin barrier feel. Not associated with pregnancy-specific concerns.
Sources: Cosmetic Ingredient Review (US)
hydroxyethylcellulose
No known risks
Cellulose-derived thickener used to build viscosity and improve texture. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR Quick Reference Table / ingredient status (Hydroxyethylcellulose, Final Report 03/2009); EU CosIng / cosmetics regulatory inventory
lactobacillus ferment
No known risks
Ferment-derived skin-conditioning ingredient used in microbiome-support and soothing formulas. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.
Sources: CIR: Safety Assessment of Lactobacillus Ferment Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
madecassoside
No known risks
A triterpene glycoside associated with Centella asiatica and used in soothing and skin-conditioning formulas. Pregnancy-specific evidence for isolated topical madecassoside is limited. Cosmetic safety reviewers considered Centella-derived ingredients acceptable at current cosmetic exposure but noted that madecassoside and related triterpenes may contribute to sensitisation, so products should be formulated to avoid sensitising concentrations. No pregnancy-specific topical contraindication was identified in the reviewed material.
Sources: CIR: Safety Assessment of Centella asiatica-Derived Ingredients as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-centella-asiatica-derived-ingredients-used-cosmetics-1
mannitol
No known risks
This sugar or sugar alcohol is used as a humectant and skin-conditioning ingredient. Cosmetic Ingredient Review assessments support these saccharides in current cosmetic use, with no pregnancy- or breastfeeding-specific concern identified for normal topical exposure.
Sources: CIR: Safety Assessment of Monosaccharides Disaccharides and Related Ingredients as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-monosaccharides-disaccharides-and-related-ingredients-used-cosmeti
microcrystalline cellulose
No known risks
This cellulose or modified-cellulose polymer is used as a thickener, film former or stabilizer. Cosmetic Ingredient Review data indicate that cellulose polymers do not appreciably penetrate skin and are safe in current cosmetic use, with at most minimal irritation reported.
Sources: CIR: Amended Safety Assessment of Cellulose and Related Polymers as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=2e65c18f-8c74-ec11-8943-0022482f06a6
niacinamide
No known risks
Niacinamide (vitamin B3) is widely used for barrier support and tone/texture benefits, and is generally considered safe in pregnancy and breastfeeding when used topically at cosmetic concentrations.
Sources: CIR; EU/UK Cosmetics Regulation
panthenol
No known risks
Panthenol (pro-vitamin B5) is used for soothing and barrier support and is generally well tolerated, with no known pregnancy or breastfeeding concerns in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation
pentylene glycol
No known risks
Humectant and preservative booster. Considered safe for cosmetic use with low systemic exposure.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
water
No known risks
Water (Aqua) is the standard purified water used as a cosmetic solvent. It has no pregnancy-specific risk in normal topical use.
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/Water, https://single-market-economy.ec.europa.eu/sectors/cosmetics/cosmetic-ingredient-database/cosing-glossary-ingredients_en
xanthan gum
No known risks
Natural polysaccharide thickener used for stability and texture. Not associated with pregnancy-specific concerns.
Sources: European cosmetics regulatory framework
xylitol
No known risks
Sugar alcohol humectant used to help maintain hydration and improve skin feel. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Safety Assessment of Mannitol, Sorbitol, and Xylitol as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
xylitylglucoside
No known risks
A sugar-derived humectant commonly used with xylitol and anhydroxylitol to support skin hydration. Exact pregnancy-specific topical data are limited. Cosmetic safety assessments of the related saccharide mixture and xylitol did not identify a reproductive or pregnancy-specific concern at cosmetic exposure; available data primarily support local tolerance rather than proving pregnancy safety. No topical contraindication was identified in the reviewed material.
Sources: CIR: Safety Assessment of Saccharide Isomerate and Related Saccharides https://cir-safety.org/supplementaldoc/safety-assessment-anhydrogalactose-anhydroglucitol-anhydroxylitol-arabinose-psicose-; CIR: Safety Assessment of Mannitol, Sorbitol, and Xylitol https://www.cir-safety.org/sites/default/files/xylito122019FR.pdf
zea mays starch
No known risks
Corn starch, a plant-derived polysaccharide used to absorb moisture, reduce greasiness and improve texture. Cosmetic safety reviewers concluded that ingredients derived from Zea mays, including corn starch, are safe in current cosmetic use. No pregnancy-specific concern is identified for normal topical exposure; avoid deliberately inhaling loose powder.
Sources: CIR ingredient review: Zea mays (Corn) Starch https://www.cir-safety.org/ingredient/zea-mays-corn-starch
Full recorded ingredient list
1,2-hexanediol, 3-o-ethyl ascorbic acid, acrylates/c10-30 alkyl acrylate crosspolymer, anhydroxylitol, arginine, betaine, butylene glycol, centella asiatica extract, ethylhexylglycerin, glucose, glycerin, hydrogenated lecithin, hydroxyethylcellulose, lactobacillus ferment, madecassoside, mannitol, microcrystalline cellulose, niacinamide, panthenol, pentylene glycol, tranexamic acid, water, xanthan gum, xylitol, xylitylglucoside, zea mays starch
Ingredient ratings refreshed 1 October 2026. Formulas vary by market and can change. Always compare with your packaging.
Questions about this assessment
Why does SKIN1004 Madagascar Centella Tone Brightening Capsule Ampoule have a Low risk rating?
The recorded formula includes 1 ingredient entry with a risk flag: tranexamic acid (Low risk). These are ingredient-level flags; they do not replace the stored product assessment or account for every formulation detail. The product score is a stored assessment, not a clinical safety guarantee.
Does this assessment cover oral or prescribed tranexamic acid?
No. Tranexamic Acid is listed in this recorded topical cosmetic. Its ingredient entry and this product score do not assess oral medication, injections or the suitability of a prescribed treatment. Read the formula-specific rating here and discuss prescribed medicines separately with your healthcare professional.
Has every ingredient in SKIN1004 Madagascar Centella Tone Brightening Capsule Ampoule been assessed?
26 of 26 ingredient entries on this page have a recorded score, evidence summary and source text. That describes documentation coverage, not proof that the finished formula has been clinically tested during pregnancy.
Does this assessment apply to my SKIN1004 Madagascar Centella Tone Brightening Capsule Ampoule?
Only if the ingredient list on your packaging matches the recorded formula shown here. Formulas can differ by market and change over time. Compare the full list, not just the product name; report a mismatch if it differs.
Does this pregnancy assessment also establish breastfeeding suitability?
No. This page presents a pregnancy-focused product assessment. Do not infer a breastfeeding conclusion from its score or label; breastfeeding requires a separate assessment of the formula and how it is used.
