Relief Sun Aqua-Fresh Rice + B5 SPF 50+

UV filter used in sunscreens and day products to help absorb UVB radiation. Reviewed cosmetic safety and regulatory sources support current cosmetic use within applicable concentration limits, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

Sources: EU CosIng Annex VI / UV filters; EU scientific opinion on Ethylhexyl Triazone (Uvinul T 150)

1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.

Sources: CIR; EU/UK Cosmetics Regulation

Organic UVA/UVB filter used in sunscreens, also known as Mexoryl XL. Cosmetic safety and regulatory sources support use within applicable concentration limits, with no pregnancy- or breastfeeding-specific topical concern identified in the sources reviewed.

Sources: EU CosIng Annex VI / UV filters; SCCS / European Commission cosmetic UV filter safety assessments; PubMed

A polyglycerin fatty-acid ester used as an emulsifier, dispersant or emollient. Cosmetic safety reviewers concluded that the assessed family of 274 polyglyceryl fatty acid esters is safe in current practices when formulated to be non-irritating. No pregnancy-specific concern was identified for normal topical cosmetic exposure.

Sources: CIR: Safety Assessment of Polyglyceryl Fatty Acid Esters as Used in Cosmetics https://www.cir-safety.org/supplementaldoc/safety-assessment-polyglyceryl-fatty-acid-esters-used-cosmetics-1

Organic UVA filter used in sunscreens, also known as Ecamsule or Mexoryl SX. Cosmetic safety and regulatory sources support use within applicable concentration limits, with no pregnancy- or breastfeeding-specific topical concern identified in the sources reviewed.

Sources: EU CosIng Annex VI / UV filters; SCCS / European Commission cosmetic UV filter safety assessments; PubMed

Modern UVA filter (often called Uvinul A+ or DHHB). Regulatory assessments have repeatedly evaluated this filter as safe in cosmetic products at concentrations up to 10%. The most recent SCCS advice focuses on controlling a manufacturing impurity (DnHexP) rather than on new toxicity of DHHB itself. Human biomonitoring data indicate low systemic exposure from normal sunscreen use, and current reviews do not identify specific reproductive or developmental toxicity signals at approved concentrations.

Sources: SCCP opinion referenced in Directive 2008/123/EC: concludes that Diethylamino Hydroxybenzoyl Hexyl Benzoate used at a maximum of 10% in cosmetic (including sunscreen) products does not pose a risk to the consumer. Regulatory summaries (e.g. CosLaw and CIRS Group updates, 2025) reviewing the SCCS DHHB opinion and reiterating that DHHB remains permitted up to 10% in EU cosmetics when impurity limits are respected.

A silicone resin used as a film former, texture enhancer and opacifying ingredient in makeup, sunscreen and skin care. The Cosmetic Ingredient Review concluded that polysilsesquioxanes including Polymethylsilsesquioxane are safe in current cosmetic use. Available evidence does not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic exposure.

Sources: CIR: Safety Assessment of Polysilsesquioxanes as Used in Cosmetics (Final Report) https://cir-safety.org/sites/default/files/PLYSIL122017FR.pdf

pH adjuster and buffer used to stabilise formulations. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Tromethamine as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Panthenol (pro-vitamin B5) is used for soothing and barrier support and is generally well tolerated, with no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

Humectant and preservative booster. Considered safe for cosmetic use with low systemic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Emulsifier and emollient used to stabilise creams and lotions. Not associated with pregnancy-specific concerns at cosmetic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Mineral absorbent and texture aid used to mattify and improve slip. Reviewed cosmetic safety sources support normal topical cosmetic use; this assessment does not cover deliberate inhalation of loose powder.

Sources: CIR: Safety Assessment of Silica and Silicates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Volatile/low-residue silicone emollient used to improve spreadability and sensory feel. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Amended Safety Assessment of Dimethicone, Methicone, and Substituted-Methicone Polymers as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

An oat kernel extract used for skin conditioning and soothing. Cosmetic safety reviewers concluded that Avena sativa kernel extract and most assessed oat-derived ingredients are safe in current practices of use and concentration when formulated to be non-sensitising and manufactured with appropriate impurity controls. Oat allergy or contact sensitivity can occur in susceptible people, but no pregnancy-specific concern was identified for normal topical cosmetic exposure.

Sources: CIR: Safety Assessment of Avena sativa (Oat)-Derived Ingredients as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=947dbaa1-8e74-ec11-8943-0022482f06a6

A botanical extract or plant water used for conditioning, soothing or antioxidant support. Direct pregnancy studies of this exact cosmetic material were not identified, but no reproductive or developmental hazard was identified for normal topical exposure. Oral herbal or medicinal use is outside this classification.

Sources: European Commission CosIng; CIR botanical safety framework and relevant plant-family assessments; no ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

A water derived from green tea leaves and used for skin conditioning. Cosmetic safety reviewers concluded that Camellia sinensis leaf water is safe in current practices when formulated to be non-sensitising.

Sources: CIR: Camellia Sinensis Leaf Water conclusion, IJT 38(Suppl. 3), 2019; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Hydrogenated emulsifier used to support skin barrier feel. Not associated with pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US)

This plant-derived fatty oil or butter is used as an emollient and skin-conditioning ingredient. The Cosmetic Ingredient Review concluded that assessed plant-derived fatty acid oils are safe as used in cosmetics; individual plant allergy and ingredient purity remain practical considerations.

Sources: CIR: Safety Assessment of Plant-Derived Fatty Acid Oils https://cir-reports.cir-safety.org/view-attachment/?id=ad62ac6b-8e74-ec11-8943-0022482f06a6

Sodium hyaluronate (hyaluronic acid salt) is used for hydration and cushioning, with very low systemic absorption from topical use and no known pregnancy or breastfeeding concerns at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Modern broad-spectrum UV filter (often known as Tinosorb S). It has a high molecular weight and is formulated to remain mainly in the outer skin layers, with very low systemic absorption at cosmetic use levels. EU regulatory assessments and independent risk–benefit reviews have evaluated this filter as safe up to 10% in sunscreens, with no specific reproductive or developmental toxicity signals identified in animals or humans at permitted concentrations.

Sources: European Union Cosmetic Products Regulation (Annex VI): Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine listed as an approved UV filter up to 10% in cosmetic products. Mikkelsen SH et al. “Survey and health assessment of UV filters” – Danish EPA, 2015: includes Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine and notes low systemic exposure at approved use levels.

Solvent and humectant used to improve texture and ingredient solubility. Low systemic exposure expected from topical cosmetic use.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

An alkyl phosphate surfactant and emulsifier used to stabilise creams, sunscreens and makeup. Cosmetic safety reviewers concluded that the assessed alkyl phosphates, including potassium cetyl phosphate, are safe in current practices of use and concentration when formulated to be non-irritating. Dermal penetration is expected to be limited, and no pregnancy-specific concern is identified for normal topical cosmetic exposure.

Sources: CIR: Safety Assessment of Alkyl Phosphates https://www.cir-safety.org/sites/default/files/alkyl%20phosphates_0.pdf

A high-molecular-weight acrylate polymer used as a film former and texture modifier. Its high molecular weight limits meaningful skin penetration. No reproductive or developmental hazard was identified for normal topical cosmetic exposure.

Sources: European Commission CosIng ingredient inventory; Cosmetic Ingredient Review botanical safety-assessment framework and relevant ingredient-family assessments. No ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

Solvent and humectant used to improve texture and ingredient delivery in topical cosmetic formulas. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.

Sources: CIR cosmetic ingredient safety references for alkane diols; EU CosIng / cosmetics regulatory inventory

Polymer thickener used to create gel textures. Large-molecule ingredient with negligible systemic absorption.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Polymer thickener and stabiliser used in creams and sunscreens. Low systemic exposure expected.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Preservative booster and skin-conditioning agent. Considered safe for cosmetic use with low systemic exposure when used as intended.

Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)

Natural polysaccharide thickener used for stability and texture. Not associated with pregnancy-specific concerns.

Sources: European cosmetics regulatory framework

Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

A high-molecular-weight polymer used for film formation, texture, stabilisation or conditioning. Meaningful dermal absorption of the intact polymer is expected to be limited, and no reproductive or developmental concern was identified for normal topical cosmetic use.

Sources: European Commission CosIng ingredient inventory; CIR cosmetic-polymer safety framework and relevant polymer-family assessments.

A large phosphorylcholine-containing conditioning polymer. Cosmetic safety reviewers concluded that acryloyloxyethyl phosphorylcholine polymers, including polyquaternium-51, are safe in current practices. Available testing did not indicate sensitisation, and dermal absorption of the finished polymer is expected to be limited.

Sources: CIR: Safety Assessment of Acryloyloxyethyl Phosphorylcholine Polymers as Used in Cosmetics https://www.cir-safety.org/sites/default/files/FR_AcryloyloxyethylPhosphorylcholinePolymers_062022.pdf

Film-forming polysaccharide used for soothing and hydration support. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Microbial Polysaccharide Gums as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Microbial polysaccharide used for film forming, soothing, and hydration support. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Microbial Polysaccharide Gums as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A naturally occurring sugar alcohol used for conditioning and hydration. Cosmetic safety reviewers concluded that inositol is safe in current practices of use and concentration. No pregnancy-specific concern was identified for normal topical cosmetic exposure.

Sources: CIR: Final Safety Assessment of Inositol, December 2024; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Vitamin E antioxidant used to protect oils and support the skin barrier. Not associated with pregnancy-specific concerns at cosmetic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

A plant-derived phenolic antioxidant used to stabilise formulas and support photoprotection. Ferulic acid is extensively metabolised after dietary exposure, and normal topical cosmetic use is expected to produce far lower systemic exposure. No pregnancy- or breastfeeding-specific hazard signal was identified in the topical and toxicology literature reviewed; irritation remains possible in acidic formulas.

Sources: European Commission CosIng ingredient inventory; PubMed literature on topical ferulic acid, dermal delivery and antioxidant use; ECHA substance information for ferulic acid.

pH adjuster used in small amounts to maintain product stability. Not associated with pregnancy-specific concerns.

Sources: Scientific Committee on Consumer Safety (EU); European cosmetics regulatory framework

Skin-identical barrier lipid used to support the stratum corneum and reduce dryness. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Ceramides as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Skin-conditioning lipid used in barrier-support formulas, commonly alongside ceramides and cholesterol. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.

Sources: CIR cosmetic ingredient safety references for sphingolipids/skin-conditioning lipids; EU CosIng / cosmetics regulatory inventory

rice amino acids is an amino acid, peptide, protein-related or glycosaminoglycan cosmetic conditioning ingredient. Expected systemic exposure from normal topical use is low, and relevant cosmetic-family assessments did not identify a pregnancy-specific concern. Manufacturing quality and residual allergenic proteins remain relevant where applicable.

Sources: CIR assessments of alpha-amino acids, plant-derived amino acids, proteins and peptides https://www.cir-safety.org/supplementaldoc/safety-assessment-%CE%B1-amino-acids-used-cosmetics; European Commission CosIng