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UV filter used in sunscreens and day products to help absorb UVB radiation. Reviewed cosmetic safety and regulatory sources support current cosmetic use within applicable concentration limits, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

Sources: EU CosIng Annex VI / UV filters; EU scientific opinion on Ethylhexyl Triazone (Uvinul T 150)

Niacinamide (vitamin B3) is widely used for barrier support and tone/texture benefits, and is generally considered safe in pregnancy and breastfeeding when used topically at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Hybrid particulate UV filter (often referred to as Tinosorb M or Bisoctrizole). It behaves more like an inorganic, microfine filter, forming a film on the skin surface with minimal percutaneous absorption. EU Scientific Committee on Consumer Safety (SCCS) opinions on both conventional and nano forms support its safe use in dermally applied cosmetic products up to 10% under current conditions of use, with main caution relating to inhalation of spray products rather than systemic toxicity from normal topical application.

Sources: SCCS opinions on Methylene Bis-Benzotriazolyl Tetramethylbutylphenol (MBBT), including SCCS/1460/11 and SCCS/1546/15: conclude that MBBT used as a UV filter up to 10% in dermal cosmetic products is safe under the evaluated conditions of use. European Commission, revision opinion on Methylene Bis-Benzotriazolyl Tetramethylbutylphenol (nano form), 2015: confirms safety of nano MBBT up to 10% in dermally applied cosmetics when used according to specified conditions

Coconut-derived emollient ester used as a lightweight skin-conditioning ingredient. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.

Sources: CIR cosmetic ingredient safety references for alkyl esters/emollient esters; EU CosIng / cosmetics regulatory inventory

Volatile/low-residue silicone emollient used to improve spreadability and sensory feel. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Amended Safety Assessment of Dimethicone, Methicone, and Substituted-Methicone Polymers as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Organic UV filter used in sunscreens, also known as Iscotrizinol or Uvasorb HEB. Available cosmetic safety and regulatory sources support use within applicable concentration limits. No pregnancy- or breastfeeding-specific topical concern was identified in the sources reviewed.

Sources: EU CosIng Annex VI / UV filters; SCCS / European Commission cosmetic UV filter safety assessments; PubMed

Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.

Sources: CIR; EU/UK Cosmetics Regulation

Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

A rice-derived extract or wax used for skin conditioning, absorbency or texture. Cosmetic safety reviewers concluded that the assessed Oryza sativa-derived ingredients are safe in current cosmetic practices. Rice allergy remains possible in a susceptible person.

Sources: CIR: Rice-derived ingredients conclusions, IJT 25(Suppl. 2), 2006; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

oryza sativa germ extract is a botanical-derived cosmetic conditioning ingredient. The reviewed identity is not a concentrated essential oil or an oral herbal preparation. Available cosmetic evidence and expected topical exposure did not identify a pregnancy-specific contraindication, although botanical irritation or allergy remains possible.

Sources: CIR ingredient-specific and botanical-family safety assessments; CIR Quick Reference Table https://www.cir-safety.org/supplementaldoc/quick-reference-table-december-2025; European Commission CosIng

Camellia sinensis (green tea) leaf extract is used as an antioxidant botanical; topical cosmetic use is considered low concern with no known pregnancy or breastfeeding risks, though rare sensitivities are possible.

Sources: CIR; EU/UK Cosmetics Regulation

lactobacillus/pumpkin ferment extract is a non-live fermentation-derived or microbial-lysate cosmetic ingredient. CIR assessments of Lactobacillus and yeast-derived cosmetic materials support use under current formulation practices. No pregnancy-specific concern was identified for normal topical use; this does not assess live organisms or oral supplements.

Sources: CIR Safety Assessment of Lactobacillus Ferment Ingredients https://cir-safety.org/supplementaldoc/safety-assessment-lactobacillus-ferment-ingredients-used-cosmetics; CIR yeast-derived ingredient assessment.

bacillus/soybean ferment extract is a non-live fermentation-derived or microbial-lysate cosmetic ingredient. CIR assessments of Lactobacillus and yeast-derived cosmetic materials support use under current formulation practices. No pregnancy-specific concern was identified for normal topical use; this does not assess live organisms or oral supplements.

Sources: CIR Safety Assessment of Lactobacillus Ferment Ingredients https://cir-safety.org/supplementaldoc/safety-assessment-lactobacillus-ferment-ingredients-used-cosmetics; CIR yeast-derived ingredient assessment.

A sugarcane extract used for skin conditioning and moisturising. Cosmetic safety reviewers concluded that Saccharum officinarum extract is safe in current cosmetic practices of use and concentration. It is not the same as a formulated high-strength alpha-hydroxy-acid peel, and no pregnancy-specific concern was identified for normal topical cosmetic exposure.

Sources: CIR: Safety Assessment of Saccharum officinarum (Sugarcane)-Derived Ingredients as Used in Cosmetics https://www.cir-safety.org/supplementaldoc/safety-assessment-saccharum-officinarum-sugarcane-derived-ingredients-used-cosmetics

A brown-algae-derived extract used for skin conditioning and hydration. Cosmetic safety reviewers specifically included this ingredient in the small subset of brown algae extracts found safe in current practices of use and concentration. Manufacturers should control naturally occurring iodine, arsenic and heavy-metal impurities.

Sources: CIR: Safety Assessment of Brown Algae-Derived Ingredients as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=c6b5b3d7-8c74-ec11-8943-0022482f06a6

A coconut fruit extract used mainly for skin conditioning. Cosmetic safety reviewers concluded that the supported Cocos nucifera-derived ingredients, including fruit extract, are safe in current practices of use and concentration. This conclusion is ingredient-specific and does not cover coconut shell powder, for which evidence was insufficient.

Sources: CIR: Safety Assessment of Cocos nucifera (Coconut)-Derived Ingredients as Used in Cosmetics https://www.cir-safety.org/sites/default/files/cocosn032021FR.pdf

A botanical root extract used as a skin-conditioning and antioxidant ingredient. Cosmetic safety reviewers concluded that Panax root-derived ingredients are safe in current practices of use and concentration. The assessment considered the biological activity of ginsenosides and available reproductive and developmental information; ordinary topical cosmetic exposure was not identified as a pregnancy-specific concern. Botanical irritation or allergy remains possible.

Sources: CIR: Safety Assessment of Panax spp. Root-Derived Ingredients as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-panax-spp-root-derived-ingredients-used-cosmetics

No pregnancy-specific harm has been identified from ordinary finished topical cosmetics containing Monascus/Rice Ferment; direct pregnancy and breastfeeding studies are limited. This rating applies to ordinary cosmetic use, not oral red-yeast-rice supplements, medicinal use or concentrated raw material. Fermentation constituents can vary, and some raw materials sold under this ingredient name are standardised to monacolins, including the statin-like compound monacolin K. The ingredient name alone does not show that a cosmetic contains such a preparation or receives an equivalent drug dose. A product documented to contain a monacolin-standardised preparation needs a separate composition-and-exposure assessment and may warrant Low Risk or a higher product-specific precaution. There is no validated topical pregnancy-safe percentage for this ferment. No Known Risks means no identified risk for the stated cosmetic use, not proof of safety for every preparation.

Sources: https://www.toyohakko.com/wp-content/uploads/2021/11/RICETECT_features_doc.pdf; https://www.nccih.nih.gov/health/red-yeast-rice; https://pub-mediabox-storage.rxweb-prd.com/exhibitor/document/exh-1a54f8e6-13c8-4399-bceb-60c06fc8fa39/87c01135-05c4-4622-83f4-557c93057027.pdf; https://www.fda.gov/drugs/drug-safety-and-availability/fda-requests-removal-strongest-warning-against-using-cholesterol-lowering-statins-during-pregnancy

Long-chain fatty alcohol used as an emollient and thickener. This is not the same concern profile as simple drying alcohols; reviewed cosmetic safety sources support normal topical use.

Sources: CIR: Final Report on the Safety Assessment of Cetearyl Alcohol, Cetyl Alcohol, Isostearyl Alcohol, Myristyl Alcohol, and Behenyl Alcohol; EU CosIng / cosmetics regulatory inventory

A high-molecular-weight acrylate polymer used as a film former and texture modifier. Its high molecular weight limits meaningful skin penetration. No reproductive or developmental hazard was identified for normal topical cosmetic exposure.

Sources: European Commission CosIng ingredient inventory; Cosmetic Ingredient Review botanical safety-assessment framework and relevant ingredient-family assessments. No ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

An emulsifier built from polyglycerin, methyl glucose and stearic-acid components, used to stabilise creams and improve texture. Exact pregnancy-specific data are limited. Cosmetic safety reviewers concluded that related methyl glucose esters and polyglyceryl fatty-acid esters are safe in current cosmetic use when formulated to be non-irritating. No pregnancy-specific topical concern was identified by applying those related-group assessments to ordinary cosmetic exposure.

Sources: CIR: Safety Assessment of Methyl Glucose Polyethers and Esters https://www.cir-safety.org/supplementaldoc/safety-assessment-methyl-glucose-polyethers-and-esters-used-cosmetics; CIR: Safety Assessment of Polyglyceryl Fatty Acid Esters https://cir-safety.org/sites/default/files/PGlyFE092016FR.pdf

Mild nonionic surfactant used in cleansers and emulsions. Reviewed cosmetic ingredient references support normal topical rinse-off and leave-on use, with no pregnancy- or breastfeeding-specific concern identified; sensitive skin may still react to surfactants.

Sources: CIR: Safety Assessment of Alkyl Glucosides as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

pH adjuster and buffer used to stabilise formulations. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Tromethamine as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Polymer thickener used to create gel textures. Large-molecule ingredient with negligible systemic absorption.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Polymer thickener and stabiliser used in creams and sunscreens. Low systemic exposure expected.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Amino-acid-derived emulsifier and skin-conditioning support ingredient. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.

Sources: CIR cosmetic ingredient safety references for amino acid alkyl amides/salts; EU CosIng / cosmetics regulatory inventory

Large polymer thickener and stabilizer used in gels, serums and creams. Systemic exposure from topical cosmetic use is expected to be low, with no pregnancy- or breastfeeding-specific concern identified in reviewed cosmetic references.

Sources: CIR cosmetic ingredient safety references for acrylates/polyacrylate crosspolymers; EU CosIng / cosmetics regulatory inventory

Skin-conditioning ingredient commonly used in leave-on skincare. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Adenosine Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Natural polysaccharide thickener used for stability and texture. Not associated with pregnancy-specific concerns.

Sources: European cosmetics regulatory framework

A volatile solvent and denaturant used in small amounts in cosmetics. Cosmetic safety reviewers concluded that t-butyl alcohol is safe in current practices of use and concentration; their assessment included reproductive and developmental data and found a large exposure margin at cosmetic use levels. It may irritate eyes or skin in concentrated form.

Sources: CIR: Amended Safety Assessment of t-Butyl Alcohol as Used in Cosmetics https://cir-safety.org/sites/default/files/FAR_t-ButylAlcohol_092024.pdf

Vitamin E antioxidant used to protect oils and support the skin barrier. Not associated with pregnancy-specific concerns at cosmetic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

lactobacillus/rice ferment is a non-live fermentation-derived or microbial-lysate cosmetic ingredient. CIR assessments of Lactobacillus and yeast-derived cosmetic materials support use under current formulation practices. No pregnancy-specific concern was identified for normal topical use; this does not assess live organisms or oral supplements.

Sources: CIR Safety Assessment of Lactobacillus Ferment Ingredients https://cir-safety.org/supplementaldoc/safety-assessment-lactobacillus-ferment-ingredients-used-cosmetics; CIR yeast-derived ingredient assessment.

A fermentation-derived cosmetic ingredient used for conditioning or formula support. Composition depends on the organism, substrate and manufacturing controls. No pregnancy-specific reproductive or developmental hazard was identified for normal topical exposure; ingestion is outside this classification.

Sources: European Commission CosIng ingredient inventory; CIR safety framework for microbial, fermentation-derived and biological-source cosmetic ingredients.

A fermentation-derived cosmetic ingredient used for conditioning or formula support. Composition depends on the organism, substrate and manufacturing controls. No pregnancy-specific reproductive or developmental hazard was identified for normal topical exposure; ingestion is outside this classification.

Sources: European Commission CosIng ingredient inventory; CIR safety framework for microbial, fermentation-derived and biological-source cosmetic ingredients.

Humectant and preservative booster. Considered safe for cosmetic use with low systemic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Preservative booster and skin-conditioning agent. Considered safe for cosmetic use with low systemic exposure when used as intended.

Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)