CeraVe
CeraVe PM Facial Moisturizing Lotion
Low risk75/100
Dr. Reju-All
Advanced PDRN Rejuvenating Cream
Night Moisturizers
Some ingredients carry a low-risk flag. Read the formulation context before deciding.
29 of 29 ingredients rated
Is it suitable during pregnancy?
MamaSkin rates the recorded formula for Dr. Reju-All Advanced PDRN Rejuvenating Cream as Low risk (79/100). Review the ingredient context and any manual-review explanation before deciding.
Why this rating?
The recorded formula includes 2 ingredient entries with risk flags: dimethicone (Low risk), sodium dna (Low risk). These are ingredient-level flags; they do not replace the stored product assessment or account for every formulation detail.
29 of 29 ingredient entries on this page have a recorded score, evidence summary and source text. That describes documentation coverage, not proof that the finished formula has been clinically tested during pregnancy.
How we assess productsIngredient breakdown
The recorded formula, with evidence behind each rating. Unmatched ingredients are marked Not assessed in grey.
Ingredient ratings and evidence
Higher-risk flags first. Open an ingredient for evidence.
dimethicone
Low risk
Dimethicone is a silicone polymer used as a skin protectant and slip/conditioning agent. It is considered inert with minimal dermal absorption; the main practical issues are cosmetic (feel) and occasional irritation in very sensitive users. It is not a pregnancy-specific concern in topical cosmetic use.
Sources: CIR: Amended Safety Assessment of Dimethicone, Methicone, and Substituted-Methicone Polymers as Used in Cosmetics https://cir-safety.org/supplementaldoc/amended-safety-assessment-dimethicone-methicone-and-substituted-methicone-polymers-2
sodium dna
Low risk
DNA-derived cosmetic ingredient/label term used in topical PDRN or polynucleotide-style skincare. Topical cosmetic use is not currently treated as a known pregnancy-restricted concern, but pregnancy-specific clinical data remain limited. MamaSkin scores this conservatively as low risk to reflect the evidence gap. This assessment applies to topical cosmetic products only and does not apply to injectable or in-clinic PDRN/polynucleotide treatments. Always review co-ingredients such as retinoids, hydroquinone, high-strength acids or other pregnancy-restricted actives separately.
Sources: Shin et al. 2025: Polynucleotide and PDRN dermatology review https://pubmed.ncbi.nlm.nih.gov/40871045/
1,2-hexanediol
No known risks
1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.
Sources: CIR; EU/UK Cosmetics Regulation
acrylates/c10-30 alkyl acrylate crosspolymer
No known risks
Polymer thickener and stabiliser used in creams and sunscreens. Low systemic exposure expected.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
adenosine
No known risks
Skin-conditioning ingredient commonly used in leave-on skincare. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Safety Assessment of Adenosine Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
Show all 29 ingredients
allantoin
No known risks
Allantoin is a soothing skin protectant commonly used to help reduce irritation and support comfort, with no known pregnancy or breastfeeding concerns in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation
aminomethyl propanediol
No known risks
An amino alcohol used to adjust pH and support formula stability. The finished product pH, rather than reproductive toxicity, is the relevant safety consideration. No pregnancy-specific systemic concern was identified for normal topical cosmetic exposure.
Sources: CIR safety assessments of amino alcohols and pH-adjusting cosmetic ingredients; European Commission CosIng ingredient inventory.
ammonium acryloyldimethyltaurate/vp copolymer
No known risks
Polymer thickener used to stabilise emulsions. Large-molecule ingredient with low systemic absorption.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
betaine
No known risks
Betaine is a humectant/osmolyte used to support hydration and reduce irritation potential in formulas; it is considered low concern with no known pregnancy or breastfeeding risks in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation
butylene glycol
No known risks
Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
caprylyl methicone
No known risks
Volatile/low-residue silicone emollient used to improve spreadability and sensory feel. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Amended Safety Assessment of Dimethicone, Methicone, and Substituted-Methicone Polymers as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
cetearyl olivate
No known risks
Emollient ester/emulsifier used to improve skin feel and stabilise emulsions. Reviewed cosmetic safety sources support topical cosmetic use; the relevant practical caveat is formulation irritation potential rather than a pregnancy-specific concern.
Sources: CIR: Amended Safety Assessment of Alkyl Esters as Used in Cosmetics; CIR Quick Reference Table (Cetearyl Olivate); EU CosIng / cosmetics regulatory inventory
ethylhexylglycerin
No known risks
Preservative booster and skin-conditioning agent. Considered safe for cosmetic use with low systemic exposure when used as intended.
Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)
glycerin
No known risks
Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation
hydrolyzed collagen
No known risks
Protein-derived skin- and hair-conditioning ingredient used to support feel and hydration at the surface. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.
Sources: CIR cosmetic ingredient safety references for protein hydrolysates; EU CosIng / cosmetics regulatory inventory
hydrolyzed hyaluronic acid
No known risks
Humectant and skin-conditioning ingredient in the hyaluronate family. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.
Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer
No known risks
Large polymer thickener, stabilizer and texture ingredient used in gels, creams and sunscreens. Systemic exposure from topical cosmetic use is expected to be low, with no pregnancy- or breastfeeding-specific concern identified in reviewed cosmetic references.
Sources: CIR cosmetic ingredient safety references for acrylates copolymers; EU CosIng / cosmetics regulatory inventory
isohexadecane
No known risks
Low-viscosity isoparaffin emollient used for slip and lightweight texture. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Safety Assessment of Isoparaffins as Used in Cosmetics / CIR Quick Reference Table (Isohexadecane); EU CosIng / cosmetics regulatory inventory
niacinamide
No known risks
Niacinamide (vitamin B3) is widely used for barrier support and tone/texture benefits, and is generally considered safe in pregnancy and breastfeeding when used topically at cosmetic concentrations.
Sources: CIR; EU/UK Cosmetics Regulation
panthenol
No known risks
Panthenol (pro-vitamin B5) is used for soothing and barrier support and is generally well tolerated, with no known pregnancy or breastfeeding concerns in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation
pentylene glycol
No known risks
Humectant and preservative booster. Considered safe for cosmetic use with low systemic exposure.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
polysorbate 80
No known risks
Nonionic emulsifier and solubilizer used to disperse oils in cosmetic formulas. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified.
Sources: CIR: Safety Assessment of Polysorbates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
sodium acrylate/sodium acryloyldimethyl taurate copolymer
No known risks
A large synthetic polymer used to thicken and stabilise cosmetic emulsions. Related acrylate copolymers have low dermal absorption because of their molecular size, and cosmetic safety reviewers concluded that this polymer family is safe when formulas avoid irritation and residual monomers are appropriately controlled. Exact pregnancy-specific topical studies are limited, but no pregnancy-specific concern was identified for normal exposure to the finished polymer in a compliant cosmetic.
Sources: CIR: Amended Safety Assessment of Acrylates Copolymers as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment?id=c3a1aad1-8c74-ec11-8943-0022482f06a6; CIR: Final Report on Acrylates Copolymer and Related Ingredients https://cir-reports.cir-safety.org/view-attachment/?id=c9cc1a17-8e74-ec11-8943-0022482f06a6
sodium hyaluronate
No known risks
Sodium hyaluronate (hyaluronic acid salt) is used for hydration and cushioning, with very low systemic absorption from topical use and no known pregnancy or breastfeeding concerns at cosmetic concentrations.
Sources: CIR; EU/UK Cosmetics Regulation
sodium phytate
No known risks
Chelating agent used to improve formula stability. Used at low levels and not associated with pregnancy-specific concerns.
Sources: European cosmetics regulatory framework
sorbitan oleate
No known risks
This sorbitan fatty-acid ester is an emulsifier that helps oil and water phases remain mixed. The Cosmetic Ingredient Review concluded that sorbitan esters are safe in current cosmetic use; occasional contact reactions remain possible in sensitive users.
Sources: CIR: Safety Assessment of Sorbitan Esters as Used in Cosmetics https://www.cir-safety.org/supplementaldoc/safety-assessment-sorbitan-esters-used-cosmetics
sorbitan olivate
No known risks
Olive-derived sorbitan ester used as an emulsifier and skin-conditioning ingredient. Reviewed cosmetic safety references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.
Sources: CIR: Safety Assessment of Sorbitan Esters as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
tocopherol
No known risks
Vitamin E antioxidant used to protect oils and support the skin barrier. Not associated with pregnancy-specific concerns at cosmetic exposure.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
water
No known risks
Water (Aqua) is the standard purified water used as a cosmetic solvent. It has no pregnancy-specific risk in normal topical use.
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/Water, https://single-market-economy.ec.europa.eu/sectors/cosmetics/cosmetic-ingredient-database/cosing-glossary-ingredients_en
Full recorded ingredient list
1,2-hexanediol, acrylates/c10-30 alkyl acrylate crosspolymer, adenosine, allantoin, aminomethyl propanediol, ammonium acryloyldimethyltaurate/vp copolymer, betaine, butylene glycol, caprylyl methicone, cetearyl olivate, dimethicone, ethylhexylglycerin, glycerin, hydrolyzed collagen, hydrolyzed hyaluronic acid, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, isohexadecane, niacinamide, panthenol, pentylene glycol, polysorbate 80, sodium acrylate/sodium acryloyldimethyl taurate copolymer, sodium dna, sodium hyaluronate, sodium phytate, sorbitan oleate, sorbitan olivate, tocopherol, water
Ingredient ratings refreshed 1 October 2026. Formulas vary by market and can change. Always compare with your packaging.
Questions about this assessment
Why does Dr. Reju-All Advanced PDRN Rejuvenating Cream have a Low risk rating?
The recorded formula includes 2 ingredient entries with risk flags: dimethicone (Low risk), sodium dna (Low risk). These are ingredient-level flags; they do not replace the stored product assessment or account for every formulation detail. The product score is a stored assessment, not a clinical safety guarantee.
Does this assessment cover injectable PDRN treatments?
No. The recorded ingredient list includes a DNA ingredient used in a topical cosmetic. This page assesses that recorded cosmetic formula, not injections, a clinic procedure or every product sold as PDRN. Check the individual ingredient entry below for its available rating and evidence.
Has every ingredient in Dr. Reju-All Advanced PDRN Rejuvenating Cream been assessed?
29 of 29 ingredient entries on this page have a recorded score, evidence summary and source text. That describes documentation coverage, not proof that the finished formula has been clinically tested during pregnancy.
Does this assessment apply to my Dr. Reju-All Advanced PDRN Rejuvenating Cream?
Only if the ingredient list on your packaging matches the recorded formula shown here. Formulas can differ by market and change over time. Compare the full list, not just the product name; report a mismatch if it differs.
Does this pregnancy assessment also establish breastfeeding suitability?
No. This page presents a pregnancy-focused product assessment. Do not infer a breastfeeding conclusion from its score or label; breastfeeding requires a separate assessment of the formula and how it is used.
