Hyalu-Cica Moisture Cream

Common emollient derived from fatty acids and glycerin. Used to soften skin and improve texture without pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Polymer thickener used to create gel textures. Large-molecule ingredient with negligible systemic absorption.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Botanical skin-conditioning ingredient used in soothing and barrier-support formulas. Reviewed cosmetic safety sources support current cosmetic use when formulated to be non-sensitising, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

Sources: CIR: Safety Assessment of Centella asiatica-derived Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Fatty alcohol used as an emollient and thickener. Not the same as drying alcohols and not associated with pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

pH adjuster used in small amounts to maintain product stability. Not associated with pregnancy-specific concerns.

Sources: Scientific Committee on Consumer Safety (EU); European cosmetics regulatory framework

An ivy-gourd fruit extract used for skin conditioning and antioxidant support. No pregnancy- or breastfeeding-specific hazard was identified for normal topical cosmetic exposure. Direct ingredient-specific pregnancy studies were not identified, so this assessment does not extend to oral supplements or medicinal use.

Sources: European Commission CosIng ingredient inventory; Cosmetic Ingredient Review botanical safety-assessment framework and relevant ingredient-family assessments. No ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

A red-algae-derived extract used for skin conditioning, hydration or formula texture. Cosmetic safety reviewers concluded that the assessed red algae ingredients, including this extract, are safe in current practices of use and concentration. Cosmetic manufacturers should control naturally occurring contaminants such as heavy metals and arsenic.

Sources: CIR: Safety Assessment of Red Algae-Derived Ingredients as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=cef5b6e9-8c74-ec11-8943-0022482f06a6

No pregnancy-specific concern is identified for ordinary intact-skin use of a conventional, diluted Cucumis melo seed extract in a finished cosmetic. This is a melon-seed preparation, not seed oil or a different cucumber species. Concentrated oral ethanol extracts produced behavioral effects in animals; dose inconsistencies and absent reproductive endpoints prevent treating that work as a cosmetic pregnancy study. Direct pregnancy and milk-transfer data are unavailable. Bitter, cucurbitacin-enriched, medicinal or absorption-enhanced preparations are excluded.

Sources: https://cosmileeurope.eu/inci/detail/3935/cucumis-melo-seed-extract/, https://kcia.or.kr/cid/search/ingd_list.php?page=329&skind=INGD_PURPOSE&sword=%ED%94%BC%EB%B6%80%EC%BB%A8%EB%94%94%EC%85%94%EB%8B%9D%EC%A0%9C, https://www.pjps.pk/uploads/pdfs/33/3/Paper%2018.pdf

Turmeric root extract is used for antioxidant and skin-conditioning effects. Pregnancy cautions relate mainly to concentrated oral supplements; normal topical cosmetic exposure is substantially smaller. The principal topical concern is irritation or allergy in sensitive users.

Sources: NIH NCCIH: Turmeric safety, including separate oral-supplement and topical cautions https://www.nccih.nih.gov/health/turmeric; European Commission CosIng ingredient inventory.

Disodium EDTA is a chelating agent used to improve formula stability and performance; it is considered low concern in topical cosmetic use, with no known pregnancy or breastfeeding risks at typical concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

A horsetail extract used mainly for skin and hair conditioning. Cosmetic safety reviewers concluded that Equisetum arvense-derived ingredients are safe in current cosmetic practices of use and concentration. This topical conclusion does not apply to oral herbal use, and botanical allergy remains possible.

Sources: CIR: Safety Assessment of Equisetum arvense-Derived Ingredients as Used in Cosmetics https://www.cir-safety.org/sites/default/files/FR_EquisetumArvense_122021.pdf

Preservative booster and skin-conditioning agent. Considered safe for cosmetic use with low systemic exposure when used as intended.

Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)

A large sugar-derived polymer used for hydration, film formation and skin conditioning. Meaningful systemic absorption through intact skin is expected to be low. No pregnancy- or breastfeeding-specific hazard signal was identified for normal topical cosmetic use; botanical or fungal source impurities and allergy should be controlled by cosmetic-grade manufacture.

Sources: European Commission CosIng ingredient inventory; CIR assessments of monosaccharides, disaccharides and related cosmetic carbohydrates; peer-reviewed cosmetic literature on fructans and Tremella fuciformis polysaccharides.

Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

Emulsifier and emollient used to stabilise creams and lotions. Not associated with pregnancy-specific concerns at cosmetic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Emulsifier and emollient ester used to stabilise creams and improve skin feel. Reviewed cosmetic safety sources support topical cosmetic use; the relevant practical caveat is formulation irritation potential rather than a pregnancy-specific concern.

Sources: CIR: Safety Assessment of Glyceryl Diesters as Used in Cosmetics; CIR Quick Reference Table (Glyceryl Stearate Citrate); EU CosIng / cosmetics regulatory inventory

A botanical extract or plant water used for conditioning, soothing or antioxidant support. Direct pregnancy studies of this exact cosmetic material were not identified, but no reproductive or developmental hazard was identified for normal topical exposure. Oral herbal or medicinal use is outside this classification.

Sources: European Commission CosIng; CIR botanical safety framework and relevant plant-family assessments; no ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

High-water-binding humectant used to support hydration at the skin surface. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Protein-derived skin- and hair-conditioning ingredient used to support feel and hydration at the surface. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.

Sources: CIR cosmetic ingredient safety references for protein hydrolysates; EU CosIng / cosmetics regulatory inventory

Humectant and skin-conditioning ingredient in the hyaluronate family. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Neem flower extract is used as a botanical skin-conditioning ingredient. A high-dose oral rat study altered the oestrous cycle and ovulation but did not show anti-implantation, abortifacient, or teratogenic effects. That oral dose does not establish a hazard from normal topical cosmetic exposure.

Sources: PubMed: high-dose oral neem flower extract reproductive study in rats https://pubmed.ncbi.nlm.nih.gov/19357745/; European Commission CosIng ingredient inventory. No human pregnancy study of normal topical cosmetic use was identified.

Neem leaf extract is used topically for skin conditioning and antimicrobial support. Reproductive concerns reported for concentrated neem seed preparations, intrauterine exposure, or high oral doses do not establish a hazard from normal topical cosmetic exposure to a leaf extract.

Sources: PubMed: oral purified neem seed extracts in primates https://pubmed.ncbi.nlm.nih.gov/8773426/; PubMed: intrauterine neem oil in primates https://pubmed.ncbi.nlm.nih.gov/8143455/; European Commission CosIng ingredient inventory. No human pregnancy study of normal topical cosmetic leaf-extract use was identified.

Banana-flower extract contains nutrient proteins and other flower constituents. Composition studies provide only limited support for cosmetic preparations and do not cover isolated medicinal fractions. Ordinary diluted use on intact external skin is expected to produce low systemic exposure, with no identified pregnancy-specific concern for that preparation. This exposure-based conclusion does not mean pregnancy safety has been proven.

Sources: https://pmc.ncbi.nlm.nih.gov/articles/PMC5785391/

Niacinamide (vitamin B3) is widely used for barrier support and tone/texture benefits, and is generally considered safe in pregnancy and breastfeeding when used topically at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Holy basil leaf extract is used for antioxidant and skin-conditioning purposes. Available warnings and pharmacology largely concern oral herbal use. No pregnancy-specific systemic hazard was identified for normal topical exposure to a compliant cosmetic, although botanical sensitivity remains possible.

Sources: PubMed: oral toxicological evaluation of Ocimum sanctum leaf extract https://pubmed.ncbi.nlm.nih.gov/24616736/; European Commission CosIng ingredient inventory. No human pregnancy study of topical cosmetic use was identified.

A plant-part extract used for skin conditioning, soothing, fragrance or antioxidant support. No pregnancy-specific systemic signal was identified for normal topical cosmetic exposure. This assessment does not extend to essential oils, oral herbal products or medicinal doses, and botanical sensitivity remains possible.

Sources: European Commission CosIng ingredient inventory; CIR botanical safety framework and relevant plant-derived ingredient assessments; peer-reviewed cosmetic-use literature.

A pentaerythritol tetraester used as an emollient, binder and texture ingredient. Cosmetic safety reviewers concluded that pentaerythrityl tetraisostearate and the reviewed related tetraesters are safe in current cosmetic use. No pregnancy- or breastfeeding-specific concern is identified for normal topical exposure.

Sources: CIR: Safety Assessment of Pentaerythrityl Tetraesters https://www.cir-safety.org/sites/default/files/120_final_penttet.pdf

A polyglycerin fatty-acid ester used as an emulsifier, dispersant or emollient. Cosmetic safety reviewers concluded that the assessed family of 274 polyglyceryl fatty acid esters is safe in current practices when formulated to be non-irritating. No pregnancy-specific concern was identified for normal topical cosmetic exposure.

Sources: CIR: Safety Assessment of Polyglyceryl Fatty Acid Esters as Used in Cosmetics https://www.cir-safety.org/supplementaldoc/safety-assessment-polyglyceryl-fatty-acid-esters-used-cosmetics-1

A polyglycerin fatty-acid ester used as an emulsifier, dispersant or emollient. Cosmetic safety reviewers concluded that the assessed family of 274 polyglyceryl fatty acid esters is safe in current practices when formulated to be non-irritating. No pregnancy-specific concern was identified for normal topical cosmetic exposure.

Sources: CIR: Safety Assessment of Polyglyceryl Fatty Acid Esters as Used in Cosmetics https://www.cir-safety.org/supplementaldoc/safety-assessment-polyglyceryl-fatty-acid-esters-used-cosmetics-1

An emulsifier built from polyglycerin, methyl glucose and stearic-acid components, used to stabilise creams and improve texture. Exact pregnancy-specific data are limited. Cosmetic safety reviewers concluded that related methyl glucose esters and polyglyceryl fatty-acid esters are safe in current cosmetic use when formulated to be non-irritating. No pregnancy-specific topical concern was identified by applying those related-group assessments to ordinary cosmetic exposure.

Sources: CIR: Safety Assessment of Methyl Glucose Polyethers and Esters https://www.cir-safety.org/supplementaldoc/safety-assessment-methyl-glucose-polyethers-and-esters-used-cosmetics; CIR: Safety Assessment of Polyglyceryl Fatty Acid Esters https://cir-safety.org/sites/default/files/PGlyFE092016FR.pdf

Solvent and humectant used to improve texture and ingredient solubility. Low systemic exposure expected from topical cosmetic use.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

prunus domestica fruit extract is a botanical-derived cosmetic conditioning ingredient. The reviewed identity is not a concentrated essential oil or an oral herbal preparation. Available cosmetic evidence and expected topical exposure did not identify a pregnancy-specific contraindication, although botanical irritation or allergy remains possible.

Sources: CIR ingredient-specific and botanical-family safety assessments; CIR Quick Reference Table https://www.cir-safety.org/supplementaldoc/quick-reference-table-december-2025; European Commission CosIng

A botanical extract, plant water or plant juice used for conditioning, soothing or antioxidant support. Direct pregnancy studies of this exact cosmetic material were not identified, but no reproductive or developmental hazard was identified for normal topical exposure. Oral herbal or medicinal use is outside this classification.

Sources: European Commission CosIng ingredient inventory; CIR botanical safety framework and relevant plant-derived ingredient assessments; no ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

A rose flower distillate used for fragrance and skin conditioning. Cosmetic safety reviewers concluded that Rosa damascena-derived ingredients, including flower water, are safe in current practices when formulated to be non-irritating and non-sensitising. Natural fragrance allergens can still affect sensitive users.

Sources: CIR: Safety Assessment of Rosa damascena-Derived Ingredients as Used in Cosmetics https://www.cir-safety.org/sites/default/files/FR_RosaDamascena_032022.pdf

No pregnancy-specific harm has been identified for ordinary, correctly formulated topical cosmetic use of sedum sarmentosum extract. This is a bounded botanical/extract assessment; direct pregnancy studies of the exact material are limited and oral, medicinal, damaged-skin or aerosol exposure is not included.

Sources: https://www.cir-safety.org/sites/default/files/Botanical%20Decision%20Tree%20CIR%20June%202012%202.pdf

Sodium hyaluronate (hyaluronic acid salt) is used for hydration and cushioning, with very low systemic absorption from topical use and no known pregnancy or breastfeeding concerns at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

A fruit, seed or food-plant extract used for skin conditioning and antioxidant support. No pregnancy-specific signal was identified for the low topical exposure expected from a finished cosmetic. Direct pregnancy studies are generally unavailable, and botanical allergy remains possible.

Sources: European Commission CosIng ingredient inventory; CIR botanical safety framework and relevant fruit-derived ingredient assessments; peer-reviewed cosmetic and phytochemical literature for the named plants.

No pregnancy-specific harm has been identified for ordinary, correctly formulated topical cosmetic use of sophora japonica flower extract. This is a bounded botanical/extract assessment; direct pregnancy studies of the exact material are limited and oral, medicinal, damaged-skin or aerosol exposure is not included.

Sources: https://www.cir-safety.org/sites/default/files/Botanical%20Decision%20Tree%20CIR%20June%202012%202.pdf

Sugar alcohol humectant used to help maintain water content at the skin surface. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Mannitol, Sorbitol, and Xylitol as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Fatty alcohol used as an emollient and stabiliser. Not associated with pregnancy-specific concerns at cosmetic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

pH adjuster and buffer used to stabilise formulations. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Tromethamine as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A cosmetic extract from an edible fruit, seed, grain, root or mushroom used for conditioning or antioxidant support. Normal topical cosmetic exposure is much lower than ordinary dietary exposure to the source material, and no pregnancy-specific hazard signal was identified. Exact extract composition varies, so source quality and individual food or plant allergy remain relevant.

Sources: European Commission CosIng ingredient inventory; CIR botanical safety framework and relevant plant-derived ingredient assessments; FDA food ingredient and GRAS inventories where applicable.

Water (Aqua) is the standard purified water used as a cosmetic solvent. It has no pregnancy-specific risk in normal topical use.

Sources: https://pubchem.ncbi.nlm.nih.gov/compound/Water, https://single-market-economy.ec.europa.eu/sectors/cosmetics/cosmetic-ingredient-database/cosing-glossary-ingredients_en