Madagascar Centella Tone Brightening Cleansing Gel Foam

An amino-acid-derived surfactant or conditioning ingredient. Cosmetic safety reviewers concluded that amino acid alkyl amides are safe in current cosmetic practices when formulated to be non-irritating. Manufacturing and formulation should control nitrosamine formation where relevant.

Sources: CIR: Safety Assessment of Amino Acid Alkyl Amides as Used in Cosmetics https://www.cir-safety.org/supplementaldoc/safety-assessment-amino-acid-alkyl-amides-used-cosmetics-0

Sodium chloride is used to adjust viscosity and texture in formulations; topical cosmetic use is considered low concern with no known pregnancy or breastfeeding risks.

Sources: CIR; EU/UK Cosmetics Regulation

A fatty-acid salt used mainly as a soap, cleanser, emulsifier or formula structurant. Cosmetic safety reviewers concluded that sodium palmate and potassium cocoate are safe in current cosmetic practices, with non-irritating formulation conditions where specified.

Sources: CIR: Sodium Palmate conclusion, IJT 36(Suppl. 3), 2017; Potassium Cocoate conclusions, IJT 30(Suppl. 1), 2011 and IJT 34(Suppl. 2), 2015; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

An amino-acid-derived surfactant or conditioning ingredient. Cosmetic safety reviewers concluded that amino acid alkyl amides are safe in current cosmetic practices when formulated to be non-irritating. Manufacturing and formulation should control nitrosamine formation where relevant.

Sources: CIR: Safety Assessment of Amino Acid Alkyl Amides as Used in Cosmetics https://www.cir-safety.org/supplementaldoc/safety-assessment-amino-acid-alkyl-amides-used-cosmetics-0

A grape fruit or seed extract used for skin conditioning and antioxidant support. Cosmetic safety reviewers concluded that the assessed Vitis vinifera-derived ingredients are safe in current practices when formulated to be non-irritating and non-sensitising. Botanical sensitivity remains possible.

Sources: CIR: Safety Assessment of Vitis vinifera (Grape)-Derived Ingredients as Used in Cosmetics https://www.cir-safety.org/supplementaldoc/safety-assessment-vitis-vinifera-grape-derived-ingredients-used-cosmetics

An apple fruit extract used mainly for skin conditioning. Cosmetic safety reviewers concluded that Pyrus malus fruit extract and the other supported apple-derived ingredients are safe in current cosmetic practices of use and concentration. The conclusion does not extend to several separately identified root, stem, callus or oil ingredients for which evidence was insufficient. No pregnancy-specific concern was identified for normal topical use of the fruit extract.

Sources: CIR: Safety Assessment of Apple-Derived Ingredients as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=6376dcde-b1aa-f075-b67c-6f6773d065ce

A papaya fruit extract used for skin conditioning. Cosmetic safety reviewers concluded that Carica papaya fruit and fruit-derived ingredients are safe in current cosmetic practices; this conclusion does not extend to papaya leaf extract, for which the available evidence was insufficient. No pregnancy-specific concern was identified for normal topical cosmetic exposure.

Sources: CIR: Safety Assessment of Carica papaya-Derived Ingredients as Used in Cosmetics, final 2025 https://cir-reports.cir-safety.org/view-attachment/?id=3ca24ad2-9f93-1b6c-a453-2da467b3c7c2

A botanical extract, juice or water used primarily for skin conditioning, moisturising, soothing or antioxidant support. Direct pregnancy studies of the named cosmetic material were not identified. No reproductive or developmental hazard was identified for normal topical exposure to a compliant finished cosmetic; oral herbal or medicinal use is outside this classification.

Sources: European Commission CosIng ingredient inventory; Cosmetic Ingredient Review botanical safety-assessment framework and relevant plant-family assessments. No ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

A triterpene glycoside associated with Centella asiatica and used in soothing and skin-conditioning formulas. Pregnancy-specific evidence for isolated topical madecassoside is limited. Cosmetic safety reviewers considered Centella-derived ingredients acceptable at current cosmetic exposure but noted that madecassoside and related triterpenes may contribute to sensitisation, so products should be formulated to avoid sensitising concentrations. No pregnancy-specific topical contraindication was identified in the reviewed material.

Sources: CIR: Safety Assessment of Centella asiatica-Derived Ingredients as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-centella-asiatica-derived-ingredients-used-cosmetics-1

1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.

Sources: CIR; EU/UK Cosmetics Regulation

A sugar-derived humectant commonly used with xylitol and anhydroxylitol to support skin hydration. Exact pregnancy-specific topical data are limited. Cosmetic safety assessments of the related saccharide mixture and xylitol did not identify a reproductive or pregnancy-specific concern at cosmetic exposure; available data primarily support local tolerance rather than proving pregnancy safety. No topical contraindication was identified in the reviewed material.

Sources: CIR: Safety Assessment of Saccharide Isomerate and Related Saccharides https://cir-safety.org/supplementaldoc/safety-assessment-anhydrogalactose-anhydroglucitol-anhydroxylitol-arabinose-psicose-; CIR: Safety Assessment of Mannitol, Sorbitol, and Xylitol https://www.cir-safety.org/sites/default/files/xylito122019FR.pdf

Sugar-derived humectant used to support hydration, often as part of saccharide blends. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Saccharide Humectants / Saccharide Isomerate, etc.; EU CosIng / cosmetics regulatory inventory

Sugar alcohol humectant used to help maintain hydration and improve skin feel. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Mannitol, Sorbitol, and Xylitol as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Niacinamide (vitamin B3) is widely used for barrier support and tone/texture benefits, and is generally considered safe in pregnancy and breastfeeding when used topically at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Polymer thickener and stabiliser used in creams and sunscreens. Low systemic exposure expected.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

A stable ether derivative of vitamin C used as an antioxidant and brightening ingredient. Pregnancy-specific topical studies are limited, but no pregnancy-specific contraindication was identified in the reviewed literature. Published case reports describe allergic contact dermatitis, so local sensitivity remains possible and this classification should not be read as proof that irritation cannot occur.

Sources: CIR: Safety Assessment of Ethers of Ascorbic Acid https://www.cir-safety.org/sites/default/files/ethers_of_ascorbate.pdf; PubMed: 3-O-ethyl-L-ascorbic acid topical delivery https://pubmed.ncbi.nlm.nih.gov/31517290/; PubMed: allergic contact dermatitis case report https://pubmed.ncbi.nlm.nih.gov/24846587/

Sugar-derived humectant used to help bind water and improve skin feel. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.

Sources: CIR: Safety Assessment of Monosaccharides, Disaccharides, and Related Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Panthenol (pro-vitamin B5) is used for soothing and barrier support and is generally well tolerated, with no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

A botanical extract, plant water or plant juice used for conditioning, soothing or antioxidant support. Direct pregnancy studies of this exact cosmetic material were not identified, but no reproductive or developmental hazard was identified for normal topical exposure. Oral herbal or medicinal use is outside this classification.

Sources: European Commission CosIng ingredient inventory; CIR botanical safety framework and relevant plant-derived ingredient assessments; no ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

Simple sugar used as a humectant and skin-conditioning support ingredient. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.

Sources: CIR: Safety Assessment of Monosaccharides, Disaccharides, and Related Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Common emollient derived from fatty acids and glycerin. Used to soften skin and improve texture without pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Solvent and humectant used to improve texture and ingredient solubility in topical cosmetics. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.

Sources: CIR cosmetic ingredient safety references for alkane diols/glycols; EU CosIng / cosmetics regulatory inventory

Humectant and preservative booster. Considered safe for cosmetic use with low systemic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

pH adjuster used in small amounts to maintain product stability. Not associated with pregnancy-specific concerns.

Sources: Scientific Committee on Consumer Safety (EU); European cosmetics regulatory framework

A functional cosmetic ingredient used for preservation support, pH control, chelation, solvent action or formula stability. Concentrated material may irritate skin or eyes, but no pregnancy-specific reproductive or developmental hazard was identified for normal use in a compliant finished cosmetic.

Sources: European Commission CosIng ingredient inventory and applicable cosmetic restrictions; relevant CIR ingredient and functional-family safety assessments.

Preservative booster and skin-conditioning agent. Considered safe for cosmetic use with low systemic exposure when used as intended.

Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)

Disodium EDTA is a chelating agent used to improve formula stability and performance; it is considered low concern in topical cosmetic use, with no known pregnancy or breastfeeding risks at typical concentrations.

Sources: CIR; EU/UK Cosmetics Regulation