A.G.E. Advanced Eye

Inert polymer used as a film former, thickener or texture ingredient in cosmetics. Normal topical use is expected to have low systemic exposure, with no pregnancy- or breastfeeding-specific concern identified in reviewed cosmetic references.

Sources: CIR cosmetic ingredient safety references for polyethylene and related polymers; EU CosIng / cosmetics regulatory inventory

Common emollient derived from fatty acids and glycerin. Used to soften skin and improve texture without pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Fatty alcohol emollient used to improve spreadability and reduce drag. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR ingredient status / report data sheet for Octyldodecanol; EU CosIng / cosmetics regulatory inventory

Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Methylxanthine used in cosmetics (e.g., de-puffing/firming and antioxidant support). No pregnancy-specific contraindications are identified for topical cosmetic use.

Sources: CIR (Methylxanthines); PubMed (NLM)

A surface-modified silica used to thicken oils and improve texture. Cosmetic safety reviewers concluded that silica silylate is safe in current practices when the final product is not irritating or sensitising to the respiratory tract. Avoid deliberately inhaling loose or airborne powder.

Sources: CIR: Safety Assessment of Silica Silylate, IJT 32(Suppl. 1), 2013; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Tocopheryl acetate (vitamin E derivative) is used as an antioxidant and skin-conditioning ingredient; it is considered low concern in topical use with no known pregnancy or breastfeeding risks at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

A high-molecular-weight polymer used to thicken and stabilise formulas. Cosmetic safety reviewers concluded that acryloyldimethyltaurate polymers are safe in current cosmetic practices. Absorption of the finished polymer is expected to be limited, with residual monomers controlled during manufacture.

Sources: CIR: Safety Assessment of Acryloyldimethyltaurate Polymers as Used in Cosmetics; final report April 2017 https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Buffering and chelating ingredient used to control pH and formulation stability. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Citric Acid, Inorganic Citrate Salts, and Alkyl Citrate Esters as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

The published CIR assessment includes the exact crosslinked silicone identity in its safe-as-used conclusion.

Sources: https://journals.sagepub.com/doi/pdf/10.1177/1091581814524963

Preservative used to help protect formulas from microbial growth. Reviewed cosmetic safety sources support present cosmetic use; no pregnancy- or breastfeeding-specific topical concern was identified in the material reviewed, although some users may still notice local irritation or sensitivity.

Sources: CIR: Safety Assessment of Chlorphenesin as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

An inert inorganic powder used to improve slip, texture and soft focus in makeup. Cosmetic safety reviewers concluded that cosmetic-grade boron nitride is safe in current cosmetic use. No pregnancy-specific concern is identified for normal skin application; as with cosmetic powders generally, avoid deliberately inhaling airborne powder or airbrush spray.

Sources: CIR: Safety Assessment of Boron Nitride as Used in Cosmetics https://www.cir-safety.org/supplementaldoc/safety-assessment-boron-nitride-used-cosmetics-0

An insoluble aluminum oxide mineral used as an absorbent, abrasive, bulking agent and surface treatment. The Cosmetic Ingredient Review concluded that alumina is safe in current cosmetic use. Normal topical exposure does not identify a pregnancy-specific concern; avoid deliberately inhaling loose powders or airbrush products.

Sources: CIR: Safety Assessment of Alumina and Aluminum Hydroxide https://www.cir-safety.org/panelbook/safety-assessment-alumina-and-aluminum-hydroxide-used-cosmetics

Colour Index name for titanium dioxide. Used as a pigment and (in some products) a mineral UV filter. For typical topical use in creams, lotions and makeup, systemic absorption is expected to be very low. Most concerns discussed in the literature relate to ingestion (E171) or inhalation from fine powders/sprays, and to nanoparticle characterisation. For routine topical cosmetic use, it is generally considered acceptable in pregnancy and breastfeeding; if you prefer a cautious approach, avoid inhaling loose powders or sprays.

Sources: EFSA opinion on titanium dioxide (E171) ingestion context; SCCS cosmetic opinions (incl. inhalation/nano considerations); general dermatology guidance on mineral sunscreens in pregnancy.

A menthol-related sensory cooling ingredient used at low cosmetic concentrations. Available cosmetic-use and toxicology information does not identify a reproductive or developmental hazard from normal topical exposure. Cooling, stinging or local irritation can occur on sensitive or damaged skin, but this is not a pregnancy-specific risk.

Sources: European Commission CosIng ingredient inventory for Menthoxypropanediol; ECHA substance information; cosmetic ingredient safety and sensory-agent literature.

Sugar alcohol humectant used to help maintain water content at the skin surface. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Mannitol, Sorbitol, and Xylitol as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A fruit, seed or food-plant extract used for skin conditioning and antioxidant support. No pregnancy-specific signal was identified for the low topical exposure expected from a finished cosmetic. Direct pregnancy studies are generally unavailable, and botanical allergy remains possible.

Sources: European Commission CosIng ingredient inventory; CIR botanical safety framework and relevant fruit-derived ingredient assessments; peer-reviewed cosmetic and phytochemical literature for the named plants.

Synthetic mica-like mineral used for bulking, optical effect, and texture. CIR concluded it is safe as used in cosmetics; normal topical use is not associated with a pregnancy- or breastfeeding-specific topical signal in the material reviewed.

Sources: CIR: Safety Assessment of Synthetic Fluorphlogopite as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Chelating agent used to improve formula stability. Used at low levels and not associated with pregnancy-specific concerns.

Sources: European cosmetics regulatory framework

Polymer thickener used to create gel textures. Large-molecule ingredient with negligible systemic absorption.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Humectant and buffer that also forms part of the skin's natural moisturising factor. Reviewed cosmetic safety sources support topical cosmetic use; irritation and sun-sensitivity considerations relate more to formula context than to pregnancy-specific risk.

Sources: CIR: Safety Assessment of Alpha Hydroxy Acids as Used in Cosmetics; CIR: PCA and Its Salts as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Nonionic surfactant and solubiliser used to disperse oils and fragrance. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Polysorbates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A pomegranate fruit extract used mainly for skin conditioning and antioxidant effects. Cosmetic safety reviewers concluded that Punica granatum fruit extract is safe in current practices when formulated to be non-irritating and non-sensitising. The conclusion is ingredient-specific and does not extend to generic whole-plant pomegranate extract.

Sources: CIR: Safety Assessment of Punica granatum-Derived Ingredients as Used in Cosmetics https://www.cir-safety.org/supplementaldoc/safety-assessment-punica-granatum-pomegranate-derived-ingredients-used-cosmetics

Volatile solvent used in some toners, sprays, and lightweight formulas. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed; the main practical issue is dryness, stinging, or barrier disruption in some users.

Sources: CIR: Safety Assessment of SD Alcohol 40, Benzyl Alcohol, and Denatured Alcohol in Cosmetic Products; EU CosIng / cosmetics regulatory inventory

Synthetic peptide used as a skin-conditioning ingredient. Reviewed cosmetic safety sources indicate no known pregnancy- or breastfeeding-specific concern in normal topical cosmetic use. Available cosmetic safety assessments conclude this ingredient is safe in the present practices of use and concentration described for cosmetics.

Sources: CIR Expert Panel, Safety Assessment of Tripeptide-1, Hexapeptide-12, their metal salts and fatty acyl derivatives, and Palmitoyl Tetrapeptide-7 as used in cosmetics, final report, 2014

Vitamin E antioxidant used to protect oils and support the skin barrier. Not associated with pregnancy-specific concerns at cosmetic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Synthetic signal peptide used in topical cosmetic anti-aging and skin-conditioning formulas. Reviewed topical peptide literature describes palmitoyl tetrapeptide-7 as a cosmetic peptide with anti-inflammatory and extracellular-matrix support activity in topical formulations. No pregnancy- or breastfeeding-specific risk signal was identified for normal topical cosmetic use.

Sources: Schagen SK. Topical Peptide Treatments with Effective Anti-Aging Results. Cosmetics. 2017;4(2):16. doi:10.3390/cosmetics4020016; CIR Expert Panel safety assessment of palmitoyl oligopeptides as used in cosmetics.

Antioxidant and stabilizer used to protect cosmetic formulas from oxidation. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.

Sources: CIR cosmetic ingredient safety references for hindered phenolic antioxidants; EU CosIng / cosmetics regulatory inventory