Cellmazing Brightening Ampoule

1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.

Sources: CIR; EU/UK Cosmetics Regulation

This emollient ester improves slip and skin feel. Cosmetic Ingredient Review assessments support use in current cosmetic concentrations when formulated to be non-irritating; topical use is not identified as a pregnancy- or breastfeeding-specific concern. Some alkyl esters can increase penetration of other formula ingredients.

Sources: CIR: Safety Assessment of Alkyl Esters as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-alkyl-esters-used-cosmetics

Betaine is a humectant/osmolyte used to support hydration and reduce irritation potential in formulas; it is considered low concern with no known pregnancy or breastfeeding risks in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

A sugar-derived humectant or starch hydrolysate used to retain moisture and support formula texture. Cosmetic safety reviewers concluded that the assessed saccharide humectants and hydrogenated starch hydrolysate are safe in current practices. Dermal absorption of larger carbohydrate materials is expected to be limited.

Sources: CIR: Saccharide Humectants safety assessment; Hydrogenated Starch Hydrolysate final report, September 2015; CIR December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Skin-conditioning ingredient commonly used in leave-on skincare. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Adenosine Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Allantoin is a soothing skin protectant commonly used to help reduce irritation and support comfort, with no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

Vitamin E antioxidant used to protect oils and support the skin barrier. Not associated with pregnancy-specific concerns at cosmetic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Panthenol (pro-vitamin B5) is used for soothing and barrier support and is generally well tolerated, with no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

Vitamin C antioxidant used to support brightness and photoprotection; functions as an antioxidant/pH adjuster in cosmetic formulas. No pregnancy-specific contraindications are identified for topical cosmetic use.

Sources: CIR (Ascorbic Acid); PubMed (NLM)

A water-soluble vitamin C derivative used as an antioxidant and skin-conditioning ingredient. Cosmetic safety reviewers concluded that sodium ascorbyl phosphate and the reviewed ascorbates are safe in cosmetic use and later reaffirmed that conclusion after reviewing updated use and safety data. No pregnancy-specific concern is identified for normal topical exposure.

Sources: CIR ingredient record: Sodium Ascorbyl Phosphate https://www.cir-safety.org/ingredient/sodium-ascorbyl-phosphate; CIR: Safety Assessment and Re-Review of Ascorbic Acid and Ascorbates https://www.cir-safety.org/sites/default/files/RRSums_2.pdf

A stable vitamin C derivative used as an antioxidant and skin-conditioning ingredient. The Cosmetic Ingredient Review concluded that ascorbyl glucoside is safe in current cosmetic use; normal topical exposure does not identify a pregnancy- or breastfeeding-specific concern.

Sources: CIR: Safety Assessment of Ascorbyl Glucoside and Sodium Ascorbyl Glucoside https://www.cir-safety.org/supplementaldoc/safety-assessment-ascorbyl-glucoside-and-sodium-ascorbyl-glucoside-used-cosmetics

Oil-soluble vitamin C derivative used as an antioxidant and skin-conditioning ingredient. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.

Sources: CIR cosmetic ingredient safety references for ascorbic acid derivatives; EU CosIng / cosmetics regulatory inventory

Preservative booster and skin-conditioning agent. Considered safe for cosmetic use with low systemic exposure when used as intended.

Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)

Humectant and preservative booster used to support product stability. Low systemic exposure expected from topical cosmetic use.

Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)

Natural polysaccharide thickener used for stability and texture. Not associated with pregnancy-specific concerns.

Sources: European cosmetics regulatory framework

A red-algae-derived extract used for skin conditioning, hydration or formula texture. Cosmetic safety reviewers concluded that the assessed red algae ingredients, including this extract, are safe in current practices of use and concentration. Cosmetic manufacturers should control naturally occurring contaminants such as heavy metals and arsenic.

Sources: CIR: Safety Assessment of Red Algae-Derived Ingredients as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=cef5b6e9-8c74-ec11-8943-0022482f06a6

ecklonia cava extract is an algae-derived cosmetic conditioning extract. Relevant CIR algae assessments support cosmetic use with species identity, cosmetic-grade purity and contaminant controls retained. No pregnancy-specific concern was identified for normal topical exposure; this does not extend to oral seaweed supplements.

Sources: CIR Safety Assessment of Brown Algae-Derived Ingredients https://www.cir-safety.org/supplementaldoc/safety-assessment-brown-algae-derived-ingredients-used-cosmetics-2; CIR red-algae assessment.

codium tomentosum extract is a botanical-derived cosmetic conditioning ingredient. The reviewed identity is not a concentrated essential oil or an oral herbal preparation. Available cosmetic evidence and expected topical exposure did not identify a pregnancy-specific contraindication, although botanical irritation or allergy remains possible.

Sources: CIR ingredient-specific and botanical-family safety assessments; CIR Quick Reference Table https://www.cir-safety.org/supplementaldoc/quick-reference-table-december-2025; European Commission CosIng

gelidium cartilagineum extract is an algae-derived cosmetic conditioning extract. Relevant CIR algae assessments support cosmetic use with species identity, cosmetic-grade purity and contaminant controls retained. No pregnancy-specific concern was identified for normal topical exposure; this does not extend to oral seaweed supplements.

Sources: CIR Safety Assessment of Brown Algae-Derived Ingredients https://www.cir-safety.org/supplementaldoc/safety-assessment-brown-algae-derived-ingredients-used-cosmetics-2; CIR red-algae assessment.

The CIR quick-reference record identifies the exact brown-algae extract as safe under its final assessment.

Sources: https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Fatty alcohol emollient used to improve spreadability and reduce drag. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR ingredient status / report data sheet for Octyldodecanol; EU CosIng / cosmetics regulatory inventory

Polymer thickener and stabiliser used in creams and sunscreens. Low systemic exposure expected.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

pH adjuster and buffer used to stabilise formulations. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Tromethamine as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Disodium EDTA is a chelating agent used to improve formula stability and performance; it is considered low concern in topical cosmetic use, with no known pregnancy or breastfeeding risks at typical concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Solvent and humectant used to improve texture and ingredient delivery in topical cosmetic formulas. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.

Sources: CIR cosmetic ingredient safety references for alkane diols; EU CosIng / cosmetics regulatory inventory

A plant-derived phenolic antioxidant used to stabilise formulas and support photoprotection. Ferulic acid is extensively metabolised after dietary exposure, and normal topical cosmetic use is expected to produce far lower systemic exposure. No pregnancy- or breastfeeding-specific hazard signal was identified in the topical and toxicology literature reviewed; irritation remains possible in acidic formulas.

Sources: European Commission CosIng ingredient inventory; PubMed literature on topical ferulic acid, dermal delivery and antioxidant use; ECHA substance information for ferulic acid.

Holy basil leaf extract is used for antioxidant and skin-conditioning purposes. Available warnings and pharmacology largely concern oral herbal use. No pregnancy-specific systemic hazard was identified for normal topical exposure to a compliant cosmetic, although botanical sensitivity remains possible.

Sources: PubMed: oral toxicological evaluation of Ocimum sanctum leaf extract https://pubmed.ncbi.nlm.nih.gov/24616736/; European Commission CosIng ingredient inventory. No human pregnancy study of topical cosmetic use was identified.

Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Hydrogenated emulsifier used to support skin barrier feel. Not associated with pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US)

Bergamot essential oil used mainly for fragrance. No pregnancy-specific hazard is established for normal topical cosmetic exposure. Expressed bergamot oil can be phototoxic unless furocoumarins are controlled, so sun-exposed use should follow the finished product directions and applicable fragrance standards.

Sources: CIR: Safety Assessment of Citrus-Derived Peel Oils as Used in Cosmetics; IFRA Standard for phototoxicity of bergamot oil

Neem leaf extract is used topically for skin conditioning and antimicrobial support. Reproductive concerns reported for concentrated neem seed preparations, intrauterine exposure, or high oral doses do not establish a hazard from normal topical cosmetic exposure to a leaf extract.

Sources: PubMed: oral purified neem seed extracts in primates https://pubmed.ncbi.nlm.nih.gov/8773426/; PubMed: intrauterine neem oil in primates https://pubmed.ncbi.nlm.nih.gov/8143455/; European Commission CosIng ingredient inventory. No human pregnancy study of normal topical cosmetic leaf-extract use was identified.

Neem flower extract is used as a botanical skin-conditioning ingredient. A high-dose oral rat study altered the oestrous cycle and ovulation but did not show anti-implantation, abortifacient, or teratogenic effects. That oral dose does not establish a hazard from normal topical cosmetic exposure.

Sources: PubMed: high-dose oral neem flower extract reproductive study in rats https://pubmed.ncbi.nlm.nih.gov/19357745/; European Commission CosIng ingredient inventory. No human pregnancy study of normal topical cosmetic use was identified.

Turmeric root extract is used for antioxidant and skin-conditioning effects. Pregnancy cautions relate mainly to concentrated oral supplements; normal topical cosmetic exposure is substantially smaller. The principal topical concern is irritation or allergy in sensitive users.

Sources: NIH NCCIH: Turmeric safety, including separate oral-supplement and topical cautions https://www.nccih.nih.gov/health/turmeric; European Commission CosIng ingredient inventory.