Cicalfate+ Restorative Protective Cream

A plant-derived fatty oil or butter used mainly as an emollient, conditioning ingredient or texture agent. Cosmetic safety reviewers concluded that the assessed plant-derived fatty acid oils are safe in current practices of use and concentration. This conclusion applies to cosmetic-grade fixed oils rather than similarly named volatile essential oils. Seed or food allergy may still matter for a susceptible person.

Sources: CIR: Safety Assessment of Plant-Derived Fatty Acid Oils as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=ad62ac6b-8e74-ec11-8943-0022482f06a6

Mineral ingredient used as a UV filter and skin protectant in many creams and mineral sunscreens. For typical topical use, systemic absorption is very low and it is generally considered acceptable in pregnancy and breastfeeding. If you prefer a cautious approach, avoid inhaling loose powders or spray formats.

Sources: General dermatology/obstetric guidance commonly lists mineral sunscreens (zinc oxide) as acceptable in pregnancy; exposure route considerations for powders/sprays.

Propylene glycol is a common solvent and humectant with a long history of use; it is not considered a pregnancy or breastfeeding concern in topical cosmetics, though some individuals may experience irritation in leave-on products.

Sources: CIR; EU/UK Cosmetics Regulation

Included in CIR's non-irritating cosmetic-use conclusion. No pregnancy-specific harm identified for ordinary topical use; pregnancy studies remain limited.

Sources: https://www.cir-safety.org/sites/default/files/PGlyFE092016FR.pdf

A fatty ester, lipid-derived emulsifier or emollient used for texture and skin conditioning. These materials have low expected systemic exposure, and no pregnancy-specific reproductive or developmental hazard was identified for normal topical cosmetic use.

Sources: CIR safety assessments of fatty esters, glycerides and emollients as used in cosmetics; European Commission CosIng ingredient inventory.

Aquaphilus Dolomiae Ferment Filtrate is a processed bacterial-fermentation ingredient used in restorative cosmetics. Studies of preparations containing it include human skin-explant models; these are not pregnancy trials or evidence of systemic reproductive safety. No pregnancy-specific harm has been identified from ordinary finished topical use; direct pregnancy and milk-transfer data are limited. The rating assumes controlled non-live cosmetic material and microbiological quality. It does not clear ingestion, injectable use, live cultures or every other ferment preparation.

Sources: https://pmc.ncbi.nlm.nih.gov/articles/PMC11472876/, https://www.avenederm.com/media/clinicals/assets/The_use_of_Aquaphilus_dolomiae_ferment_filtrate_restorative_cream_with_topical_corticosteroids.pdf

Amino acid used as a humectant, skin-conditioning agent, and pH-adjusting support ingredient. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of α-Amino Acids as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

This wax is used as an emollient and structuring ingredient. Cosmetic Ingredient Review assessments support current cosmetic use, with no pregnancy- or breastfeeding-specific concern identified; uncommon contact allergy can occur, particularly with natural wax components.

Sources: CIR: Safety Assessment of Beeswax Carnauba Wax and Candelilla Wax https://www.cir-safety.org/sites/default/files/RR_Waxes.pdf

Copper Sulfate is a mineral salt used in small amounts in skin-conditioning formulas. Human-skin formulation studies found minimal copper passage from the evaluated sulfate creams, comparable to Copper PCA; direct pregnancy studies are lacking. No pregnancy-specific harm has been identified from ordinary dilute finished cosmetics on intact skin. Concentrated salts can irritate, and excessive systemic copper exposure can be harmful. This rating does not cover oral supplements, medicinal treatment, extensive damaged-skin application or enhanced-delivery preparations. Published use at0.1% is a formulation example, not a pregnancy-safe percentage for every product. Stop use if irritation or an allergic reaction occurs.

Sources: https://pubmed.ncbi.nlm.nih.gov/8896117/, https://pmc.ncbi.nlm.nih.gov/articles/PMC6053173/, https://www.atsdr.cdc.gov/toxprofiles/tp132-c2.pdf, https://www.canada.ca/en/environment-climate-change/services/evaluating-existing-substances/draft-screening-assessment-copper-compounds.html

A magnesium salt of stearic acid used for texture, adhesion and slip. Cosmetic safety reviewers concluded that magnesium stearate is safe in current practices when formulated to be non-irritating and non-sensitising. Loose powders should still be used without deliberately inhaling them.

Sources: CIR: Quick Reference Table and amended metallic stearates conclusion https://www.cir-safety.org/sites/default/files/sq-fix_2.pdf

Highly refined mineral wax used to thicken and stabilise formulas. Cosmetic-grade microcrystalline wax has minimal skin absorption and no known pregnancy-specific concerns in topical use as intended. Concerns raised online typically relate to unrefined mineral oil impurities or dietary exposure, not cosmetic-grade topical use.

Sources: Cosmetic Ingredient Review (CIR) ingredient dossier for Microcrystalline Wax + CIR wax safety assessment materials. ; Petry et al. (2017) dermal penetration review (includes mineral oils/waxes). ; BfR, Highly refined mineral oils in cosmetics (context on refined mineral oil fractions/waxes in cosmetics) (2018).

pH adjuster and buffer used to stabilise formulations. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Tromethamine as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

An inorganic mineral salt used for formula support, pH adjustment or skin conditioning. Cosmetic safety reviewers concluded that zinc sulfate and sodium carbonate are safe in current cosmetic practices, with non-irritating formulation conditions where specified.

Sources: CIR: Zinc Sulfate final assessment, March 2018; Sodium Carbonate conclusions, JACT 6(1), 1987 and IJT 44(Suppl. 3), 2025; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf