Avène Cicalfate+ Restorative Protective Cream by Avène
Avène

Avène Cicalfate+ Restorative Protective Cream

General Moisturizersmoisturisers

Safety score

Pregnancy-focused assessment

No Known Risks99/100
Higher concernLower concern

No higher-risk ingredients were identified in MamaSkin's current assessment. Check the latest package before deciding.

Ingredient safety review updated 24 November 2025.

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Ingredient breakdown

See how the listed formula falls across MamaSkin's pregnancy-focused risk bands.

18

No known risks

0

Low risk

0

Medium risk

0

High risk

Ingredients

Ingredients with a higher risk flag appear first, followed by the rest of the formula.

Water

No Known Risks

Caprylic/Capric Triglyceride

No Known Risks

Common emollient derived from fatty acids and glycerin. Used to soften skin and improve texture without pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Paraffinum Liquidum

No Known Risks

Highly refined mineral oil (occlusive emollient). Cosmetic-grade mineral oil has very low skin absorption and is widely considered safe for topical use during pregnancy when used as intended. Concerns raised online typically relate to unrefined/poorly refined mineral oils and dietary mineral oil hydrocarbons, not regulated cosmetic-grade topical use.

Sources: BfR (Federal Institute for Risk Assessment), Highly refined mineral oils in cosmetics: Health risks are not to be expected according to current knowledge (2018). ; Petry et al., Review of data on the dermal penetration of mineral oils and waxes used in cosmetic products (Food and Chemical Toxicology, 2017). ; EFSA, Scientific Opinion on Mineral Oil Hydrocarbons in Food (2012).

Show all (18)

Glycerin

No Known Risks

Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

Hydrogenated Vegetable Oil

No Known Risks

A plant-derived fatty oil or butter used mainly as an emollient, conditioning ingredient or texture agent. Cosmetic safety reviewers concluded that the assessed plant-derived fatty acid oils are safe in current practices of use and concentration. This conclusion applies to cosmetic-grade fixed oils rather than similarly named volatile essential oils. Seed or food allergy may still matter for a susceptible person.

Sources: CIR: Safety Assessment of Plant-Derived Fatty Acid Oils as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=ad62ac6b-8e74-ec11-8943-0022482f06a6

Zinc Oxide

No Known Risks

Mineral ingredient used as a UV filter and skin protectant in many creams and mineral sunscreens. For typical topical use, systemic absorption is very low and it is generally considered acceptable in pregnancy and breastfeeding. If you prefer a cautious approach, avoid inhaling loose powders or spray formats.

Sources: General dermatology/obstetric guidance commonly lists mineral sunscreens (zinc oxide) as acceptable in pregnancy; exposure route considerations for powders/sprays.

Propylene Glycol

No Known Risks

Propylene glycol is a common solvent and humectant with a long history of use; it is not considered a pregnancy or breastfeeding concern in topical cosmetics, though some individuals may experience irritation in leave-on products.

Sources: CIR; EU/UK Cosmetics Regulation

Polyglyceryl-2 Sesquiisostearate

No Known Risks

PEG-22/Dodecyl Glycol Copolymer

No Known Risks

Aluminum Stearate

No Known Risks

Aquaphilus Dolomiae Ferment Filtrate

No Known Risks

Arginine

No Known Risks

Amino acid used as a humectant, skin-conditioning agent, and pH-adjusting support ingredient. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of α-Amino Acids as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Beeswax

No Known Risks

This wax is used as an emollient and structuring ingredient. Cosmetic Ingredient Review assessments support current cosmetic use, with no pregnancy- or breastfeeding-specific concern identified; uncommon contact allergy can occur, particularly with natural wax components.

Sources: CIR: Safety Assessment of Beeswax Carnauba Wax and Candelilla Wax https://www.cir-safety.org/sites/default/files/RR_Waxes.pdf

Copper Sulfate

No Known Risks

Magnesium Stearate

No Known Risks

A magnesium salt of stearic acid used for texture, adhesion and slip. Cosmetic safety reviewers concluded that magnesium stearate is safe in current practices when formulated to be non-irritating and non-sensitising. Loose powders should still be used without deliberately inhaling them.

Sources: CIR: Quick Reference Table and amended metallic stearates conclusion https://www.cir-safety.org/sites/default/files/sq-fix_2.pdf

Microcrystalline Wax

No Known Risks

Highly refined mineral wax used to thicken and stabilise formulas. Cosmetic-grade microcrystalline wax has minimal skin absorption and no known pregnancy-specific concerns in topical use as intended. Concerns raised online typically relate to unrefined mineral oil impurities or dietary exposure, not cosmetic-grade topical use.

Sources: Cosmetic Ingredient Review (CIR) ingredient dossier for Microcrystalline Wax + CIR wax safety assessment materials. ; Petry et al. (2017) dermal penetration review (includes mineral oils/waxes). ; BfR, Highly refined mineral oils in cosmetics (context on refined mineral oil fractions/waxes in cosmetics) (2018).

Tromethamine

No Known Risks

pH adjuster and buffer used to stabilise formulations. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Tromethamine as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Zinc Sulfate

No Known Risks

Formulations can change without notice. For the most accurate result, compare this list with your packaging and scan the exact ingredient label in MamaSkin when you repurchase.

How to use this assessment

The risk band is the primary conclusion. The score adds detail within that band and should not be used to compare products as if a one-point difference were clinically meaningful.

MamaSkin provides pregnancy-focused information, not medical advice. Your midwife, GP, pharmacist or dermatologist should take priority when your circumstances differ from typical cosmetic use.

Read the full methodology