0.1% Gentle Retinol Serum

Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

A diester used as an emollient, solvent and plasticizer. After reviewing additional dermal, reproductive, developmental and genotoxicity data, cosmetic safety reviewers concluded that dibutyl adipate is safe in current cosmetic use and concentration. No pregnancy-specific concern is identified for normal topical cosmetic exposure.

Sources: CIR: Amended Final Report of the Safety Assessment of Dibutyl Adipate https://cir-reports.cir-safety.org/view-attachment?id=f1624b41-8e74-ec11-8943-0022482f06a6

1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.

Sources: CIR; EU/UK Cosmetics Regulation

Panthenol (pro-vitamin B5) is used for soothing and barrier support and is generally well tolerated, with no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

Plant-derived emollient oil used to soften skin and support formula texture. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

Sources: CIR: Safety Assessment of Soy-Derived Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Hydrogenated emulsifier used to support skin barrier feel. Not associated with pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US)

Common emollient derived from fatty acids and glycerin. Used to soften skin and improve texture without pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

An emulsifier built from polyglycerin, methyl glucose and stearic-acid components, used to stabilise creams and improve texture. Exact pregnancy-specific data are limited. Cosmetic safety reviewers concluded that related methyl glucose esters and polyglyceryl fatty-acid esters are safe in current cosmetic use when formulated to be non-irritating. No pregnancy-specific topical concern was identified by applying those related-group assessments to ordinary cosmetic exposure.

Sources: CIR: Safety Assessment of Methyl Glucose Polyethers and Esters https://www.cir-safety.org/supplementaldoc/safety-assessment-methyl-glucose-polyethers-and-esters-used-cosmetics; CIR: Safety Assessment of Polyglyceryl Fatty Acid Esters https://cir-safety.org/sites/default/files/PGlyFE092016FR.pdf

Polymer used for texture and absorbency. Large-molecule ingredient with low systemic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Large polymer thickener, stabilizer and texture ingredient used in gels, creams and sunscreens. Systemic exposure from topical cosmetic use is expected to be low, with no pregnancy- or breastfeeding-specific concern identified in reviewed cosmetic references.

Sources: CIR cosmetic ingredient safety references for acrylates copolymers; EU CosIng / cosmetics regulatory inventory

A large synthetic polymer used to thicken and stabilise cosmetic emulsions. Related acrylate copolymers have low dermal absorption because of their molecular size, and cosmetic safety reviewers concluded that this polymer family is safe when formulas avoid irritation and residual monomers are appropriately controlled. Exact pregnancy-specific topical studies are limited, but no pregnancy-specific concern was identified for normal exposure to the finished polymer in a compliant cosmetic.

Sources: CIR: Amended Safety Assessment of Acrylates Copolymers as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment?id=c3a1aad1-8c74-ec11-8943-0022482f06a6; CIR: Final Report on Acrylates Copolymer and Related Ingredients https://cir-reports.cir-safety.org/view-attachment/?id=c9cc1a17-8e74-ec11-8943-0022482f06a6

A botanical extract, plant water or plant juice used for conditioning, soothing or antioxidant support. Direct pregnancy studies of this exact cosmetic material were not identified, but no reproductive or developmental hazard was identified for normal topical exposure. Oral herbal or medicinal use is outside this classification.

Sources: European Commission CosIng ingredient inventory; CIR botanical safety framework and relevant plant-derived ingredient assessments; no ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

Bakuchiol is a plant-derived skincare ingredient used as a retinol alternative. Although it can show some retinol-like cosmetic effects, it is not a retinoid or vitamin A derivative. Human topical studies suggest good tolerability, and current literature does not identify a known pregnancy-specific risk signal for topical cosmetic use. Overall, it is generally considered a lower-concern alternative to retinoids in pregnancy, while recognising that direct pregnancy-specific studies remain limited.

Sources: PubMed (NLM): Chaudhuri & Bojanowski 2014 (PMID 24471735); Br J Dermatol bakuchiol vs retinol randomized trial (PMID 29947134); J Drugs Dermatol bakuchiol moisturizer trial in sensitive skin (PMID 33346506); J Drugs Dermatol systematic review of human topical bakuchiol trials (PMID 38564402); Contact Dermatitis case reports (PMIDs 30644106, 31423588); PMC review noting lack of pregnancy-specific studies (PMCID PMC10683784).

A large, mostly insoluble polymer used as a binder, film former and texture ingredient. Cosmetic safety reviewers concluded that polyisobutene is safe in current cosmetic use; slow absorption and reproductive data on related polybutene do not indicate a pregnancy-specific concern from normal topical exposure.

Sources: CIR: Final Report on Polyisobutene and Hydrogenated Polyisobutene https://www.cir-safety.org/sites/default/files/polyene.pdf

Preservative booster and skin-conditioning agent. Considered safe for cosmetic use with low systemic exposure when used as intended.

Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)

Allantoin is a soothing skin protectant commonly used to help reduce irritation and support comfort, with no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

A high-molecular-weight polymer used to hold water and stabilise texture. Cosmetic safety reviewers concluded that glyceryl acrylate/acrylic acid copolymer is safe in current cosmetic practices. Dermal absorption of the finished polymer is expected to be limited; residual monomers should be controlled by cosmetic manufacturing standards.

Sources: CIR: Safety Assessment of Glyceryl Acrylate/Acrylic Acid Copolymer and Glyceryl Polyacrylate https://cir-reports.cir-safety.org/view-attachment/?id=c79ac89b-d78d-055f-ba88-45f4f5a039b3

Disodium EDTA is a chelating agent used to improve formula stability and performance; it is considered low concern in topical cosmetic use, with no known pregnancy or breastfeeding risks at typical concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Emulsifier used to help oil and water phases remain mixed. Reviewed cosmetic safety sources support topical use in cosmetics; the main practical issue is irritation potential in some formulas rather than a pregnancy-specific concern.

Sources: CIR: Safety Assessment of Sorbitan Esters as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A high-molecular-weight film-forming copolymer used in hair, oral-care and skin products. Cosmetic safety reviewers concluded that PVM/MA copolymer is safe in current practices of use and concentration. Absorption of the intact polymer is expected to be limited.

Sources: CIR: Safety Assessment of PVM/MA Copolymer and Its Esters, IJT 30(Suppl. 2), 2011; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

This sorbitan fatty-acid ester is an emulsifier that helps oil and water phases remain mixed. The Cosmetic Ingredient Review concluded that sorbitan esters are safe in current cosmetic use; occasional contact reactions remain possible in sensitive users.

Sources: CIR: Safety Assessment of Sorbitan Esters as Used in Cosmetics https://www.cir-safety.org/supplementaldoc/safety-assessment-sorbitan-esters-used-cosmetics

This glucose-derived nonionic surfactant or emulsifier is used in cleansers and emulsions. The Cosmetic Ingredient Review concluded that alkyl glucosides are safe in current cosmetic use when formulated to be non-irritating; sensitive skin can still react to surfactants.

Sources: CIR: Safety Assessment of Decyl Glucoside and Other Alkyl Glucosides as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=9810a771-8e74-ec11-8943-0022482f06a6

hyacinthus orientalis extract is a botanical-derived cosmetic conditioning ingredient. The reviewed identity is not an essential oil or an oral herbal preparation. Available cosmetic evidence and expected topical exposure did not identify a pregnancy-specific contraindication, although botanical irritation or allergy remains possible.

Sources: CIR ingredient-specific and botanical-family safety assessments; CIR Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf; European Commission CosIng

A German chamomile flower extract used for skin conditioning and soothing. Cosmetic safety reviewers concluded that Chamomilla recutita flower-derived ingredients are safe in current cosmetic use when formulated to be non-sensitizing. Chamomile can cause contact allergy in susceptible people, particularly those sensitive to plants in the Asteraceae family, but no pregnancy-specific concern is identified for normal topical cosmetic exposure.

Sources: CIR: Safety Assessment of Chamomilla Recutita-Derived Ingredients as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-chamomilla-recutita-derived-ingredients-used-cosmetics-0

A cornflower extract used for soothing and skin conditioning. No pregnancy- or breastfeeding-specific hazard was identified for normal topical cosmetic exposure. Direct ingredient-specific pregnancy studies were not identified, so this assessment does not extend to oral supplements or medicinal use.

Sources: European Commission CosIng ingredient inventory; Cosmetic Ingredient Review botanical safety-assessment framework and relevant ingredient-family assessments. No ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

A plant-part extract used for skin conditioning, soothing, fragrance or antioxidant support. No pregnancy-specific systemic signal was identified for normal topical cosmetic exposure. This assessment does not extend to essential oils, oral herbal products or medicinal doses, and botanical sensitivity remains possible.

Sources: European Commission CosIng ingredient inventory; CIR botanical safety framework and relevant plant-derived ingredient assessments; peer-reviewed cosmetic-use literature.

Vitamin E antioxidant used to protect oils and support the skin barrier. Not associated with pregnancy-specific concerns at cosmetic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)