Dr. Althea
Dr. Althea Gentle Vitamin C Serum
No known risks99/100
Dr. Althea
345 Relief Cream
General Moisturizers
Some ingredients carry a low-risk flag. Read the formulation context before deciding.
38 of 38 ingredients rated
Is it suitable during pregnancy?
MamaSkin rates the recorded formula for Dr. Althea 345 Relief Cream as Low risk (79/100). Review the ingredient context and any manual-review explanation before deciding.
Why this rating?
The recorded formula includes 4 ingredient entries with risk flags: Vinyldimethicone (Low risk), Coptis Japonica Root Extract (Low risk), Resveratrol (Low risk), plus others listed in the breakdown. These are ingredient-level flags; they do not replace the stored product assessment or account for every formulation detail.
38 of 38 ingredient entries on this page have a recorded score, evidence summary and source text. That describes documentation coverage, not proof that the finished formula has been clinically tested during pregnancy.
How we assess productsIngredient breakdown
The recorded formula, with evidence behind each rating. Unmatched ingredients are marked Not assessed in grey.
Ingredient ratings and evidence
Higher-risk flags first. Open an ingredient for evidence.
Vinyldimethicone
Low risk
This ingredient is a silicone polymer included in CIR's dimethicone, methicone and substituted-methicone family assessment. CIR concluded the reviewed ingredients safe as used when formulated to be non-irritating to skin and eyes. This is family-level cosmetic evidence, not ingredient-specific human pregnancy evidence for every derivative. MamaSkin therefore retains Low Risk without claiming negligible absorption for this individual ingredient.
Sources: CIR: Amended safety assessment of dimethicone and related methicone polymers https://cir-safety.org/supplementaldoc/amended-safety-assessment-dimethicone-methicone-and-substituted-methicone-polymers-2
Coptis Japonica Root Extract
Low risk
Coptis japonica root contains isoquinoline alkaloids including berberine. Oral berberine has limited pregnancy data and precautionary concerns involving uterine activity and bilirubin displacement, while breastfeeding exposure is also discouraged. A cosmetic extract is used topically at much lower exposure and may vary in composition, so MamaSkin applies a precautionary Low Risk classification rather than an oral-supplement-level warning.
Sources: PubMed: Coptis japonica root-derived alkaloids including berberine, palmatine and coptisine https://pubmed.ncbi.nlm.nih.gov/10552394/; MotherToBaby: Berberine https://www.ncbi.nlm.nih.gov/books/NBK600384/; European Commission CosIng ingredient inventory.
Resveratrol
Low risk
Resveratrol is a polyphenolic antioxidant used in topical skincare. A high-dose dietary study in pregnant nonhuman primates reported an unexplained alteration in fetal pancreatic development and cautioned against resveratrol supplementation during pregnancy. Topical delivery studies indicate substantially lower and largely skin-localised exposure. MamaSkin therefore applies a precautionary Low Risk classification rather than treating topical cosmetic use like oral supplementation.
Sources: PubMed: Beneficial and cautionary outcomes of resveratrol supplementation in pregnant nonhuman primates https://pubmed.ncbi.nlm.nih.gov/24563374/; PubMed: Topical delivery and skin disposition of resveratrol https://pubmed.ncbi.nlm.nih.gov/28389713/; LactMed: Resveratrol https://www.ncbi.nlm.nih.gov/books/NBK501879/.
Sodium Dna
Low risk
DNA-derived cosmetic ingredient/label term used in topical PDRN or polynucleotide-style skincare. Topical cosmetic use is not currently treated as a known pregnancy-restricted concern, but pregnancy-specific clinical data remain limited. MamaSkin scores this conservatively as low risk to reflect the evidence gap. This assessment applies to topical cosmetic products only and does not apply to injectable or in-clinic PDRN/polynucleotide treatments. Always review co-ingredients such as retinoids, hydroquinone, high-strength acids or other pregnancy-restricted actives separately.
Sources: Shin et al. 2025: Polynucleotide and PDRN dermatology review https://pubmed.ncbi.nlm.nih.gov/40871045/
Water
No known risks
Water (Aqua) is the standard purified water used as a cosmetic solvent. It has no pregnancy-specific risk in normal topical use.
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/Water, https://single-market-economy.ec.europa.eu/sectors/cosmetics/cosmetic-ingredient-database/cosing-glossary-ingredients_en
Show all 38 ingredients
Melaleuca Alternifolia Leaf Water
No known risks
A botanical extract, plant water or plant juice used for conditioning, soothing or antioxidant support. Direct pregnancy studies of this exact cosmetic material were not identified, but no reproductive or developmental hazard was identified for normal topical exposure. Oral herbal or medicinal use is outside this classification.
Sources: European Commission CosIng ingredient inventory; CIR botanical safety framework and relevant plant-derived ingredient assessments; no ingredient-specific human pregnancy study of normal topical cosmetic use was identified.
Propanediol
No known risks
Solvent and humectant used to improve texture and ingredient solubility. Low systemic exposure expected from topical cosmetic use.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
Glycerin
No known risks
Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation
1,2-Hexanediol
No known risks
1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.
Sources: CIR; EU/UK Cosmetics Regulation
Hydrogenated Polydecene
No known risks
Synthetic hydrocarbon emollient used to improve slip, cushion and moisture feel. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.
Sources: CIR cosmetic ingredient safety references for polydecenes/hydrocarbon emollients; EU CosIng / cosmetics regulatory inventory
C14-22 Alcohols
No known risks
A long-chain fatty alcohol or fatty-alcohol blend used as an emollient, emulsifier or thickener. Cosmetic safety assessments of long-chain fatty alcohols support use in current cosmetic practices; systemic absorption and reproductive exposure from normal topical use are expected to be low.
Sources: CIR: Safety Assessment of Fatty Alcohols as Used in Cosmetics; CIR December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf
Niacinamide
No known risks
Niacinamide (vitamin B3) is widely used for barrier support and tone/texture benefits, and is generally considered safe in pregnancy and breastfeeding when used topically at cosmetic concentrations.
Sources: CIR; EU/UK Cosmetics Regulation
Caprylic/Capric Triglyceride
No known risks
Common emollient derived from fatty acids and glycerin. Used to soften skin and improve texture without pregnancy-specific concerns.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
Panthenol
No known risks
Panthenol (pro-vitamin B5) is used for soothing and barrier support and is generally well tolerated, with no known pregnancy or breastfeeding concerns in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation
Dicaprylyl Carbonate
No known risks
Light emollient carbonate ester used to improve spreadability and reduce greasiness. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Safety Assessment of Dialkyl Carbonates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
Butylene Glycol
No known risks
Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
Ammonium Acryloyldimethyltaurate/Vp Copolymer
No known risks
Polymer thickener used to stabilise emulsions. Large-molecule ingredient with low systemic absorption.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
Caprylyl Methicone
No known risks
Volatile/low-residue silicone emollient used to improve spreadability and sensory feel. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Amended Safety Assessment of Dimethicone, Methicone, and Substituted-Methicone Polymers as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
Polymethylsilsesquioxane
No known risks
A silicone resin used as a film former, texture enhancer and opacifying ingredient in makeup, sunscreen and skin care. The Cosmetic Ingredient Review concluded that polysilsesquioxanes including Polymethylsilsesquioxane are safe in current cosmetic use. Available evidence does not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic exposure.
Sources: CIR: Safety Assessment of Polysilsesquioxanes as Used in Cosmetics (Final Report) https://cir-safety.org/sites/default/files/PLYSIL122017FR.pdf
C12-20 Alkyl Glucoside
No known risks
A sugar-derived surfactant and emulsifier. Cosmetic safety reviewers concluded that alkyl glucosides, including C12-20 alkyl glucoside, are safe in current practices when formulated to be non-irritating.
Sources: CIR: Alkyl Glucosides conclusion, IJT 32(Suppl. 3), 2013; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf
Hydroxyacetophenone
No known risks
Hydroxyacetophenone is used as an antioxidant and preservative-support ingredient; it is generally considered low concern in topical cosmetic use with no known pregnancy or breastfeeding risks at typical concentrations.
Sources: CIR; EU/UK Cosmetics Regulation
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
No known risks
Polymer thickener and stabiliser used in creams and sunscreens. Low systemic exposure expected.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
Polyquaternium-51
No known risks
A large phosphorylcholine-containing conditioning polymer. Cosmetic safety reviewers concluded that acryloyloxyethyl phosphorylcholine polymers, including polyquaternium-51, are safe in current practices. Available testing did not indicate sensitisation, and dermal absorption of the finished polymer is expected to be limited.
Sources: CIR: Safety Assessment of Acryloyloxyethyl Phosphorylcholine Polymers as Used in Cosmetics https://www.cir-safety.org/sites/default/files/FR_AcryloyloxyethylPhosphorylcholinePolymers_062022.pdf
Ethylhexylglycerin
No known risks
Preservative booster and skin-conditioning agent. Considered safe for cosmetic use with low systemic exposure when used as intended.
Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)
Tromethamine
No known risks
pH adjuster and buffer used to stabilise formulations. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Safety Assessment of Tromethamine as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
Sodium Hyaluronate
No known risks
Sodium hyaluronate (hyaluronic acid salt) is used for hydration and cushioning, with very low systemic absorption from topical use and no known pregnancy or breastfeeding concerns at cosmetic concentrations.
Sources: CIR; EU/UK Cosmetics Regulation
Sodium Stearoyl Glutamate
No known risks
Amino-acid-derived emulsifier and skin-conditioning support ingredient. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.
Sources: CIR cosmetic ingredient safety references for amino acid alkyl amides/salts; EU CosIng / cosmetics regulatory inventory
Centella Asiatica Leaf Water
No known risks
A botanical extract, juice or water used primarily for skin conditioning, moisturising, soothing or antioxidant support. Direct pregnancy studies of the named cosmetic material were not identified. No reproductive or developmental hazard was identified for normal topical exposure to a compliant finished cosmetic; oral herbal or medicinal use is outside this classification.
Sources: European Commission CosIng ingredient inventory; Cosmetic Ingredient Review botanical safety-assessment framework and relevant plant-family assessments. No ingredient-specific human pregnancy study of normal topical cosmetic use was identified.
Beta-Glucan
No known risks
Film-forming polysaccharide used for soothing and hydration support. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Safety Assessment of Microbial Polysaccharide Gums as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
Hydrolyzed Hyaluronic Acid
No known risks
Humectant and skin-conditioning ingredient in the hyaluronate family. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.
Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
Camellia Sinensis Leaf Water
No known risks
A water derived from green tea leaves and used for skin conditioning. Cosmetic safety reviewers concluded that Camellia sinensis leaf water is safe in current practices when formulated to be non-sensitising.
Sources: CIR: Camellia Sinensis Leaf Water conclusion, IJT 38(Suppl. 3), 2019; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf
Tocopherol
No known risks
Vitamin E antioxidant used to protect oils and support the skin barrier. Not associated with pregnancy-specific concerns at cosmetic exposure.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
Madecassoside
No known risks
A triterpene glycoside associated with Centella asiatica and used in soothing and skin-conditioning formulas. Pregnancy-specific evidence for isolated topical madecassoside is limited. Cosmetic safety reviewers considered Centella-derived ingredients acceptable at current cosmetic exposure but noted that madecassoside and related triterpenes may contribute to sensitisation, so products should be formulated to avoid sensitising concentrations. No pregnancy-specific topical contraindication was identified in the reviewed material.
Sources: CIR: Safety Assessment of Centella asiatica-Derived Ingredients as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-centella-asiatica-derived-ingredients-used-cosmetics-1
Centella Asiatica Extract
No known risks
Botanical skin-conditioning ingredient used in soothing and barrier-support formulas. Reviewed cosmetic safety sources support current cosmetic use when formulated to be non-sensitising, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.
Sources: CIR: Safety Assessment of Centella asiatica-derived Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
Ceramide NP
No known risks
Skin-identical barrier lipid used to support the stratum corneum and reduce dryness. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Safety Assessment of Ceramides as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
Tannic Acid
No known risks
For ordinary, correctly formulated topical cosmetic use, no pregnancy-specific harm has been identified for tannic acid. Astringent polyphenol with low intact-skin penetration; avoid medicinal application to damaged or extensive skin. Direct pregnancy studies of this exact material are limited; this assessment does not cover ingestion, medicinal-strength use, damaged skin, or aerosol exposure.
Sources: https://www.epa.gov/sites/production/files/2015-04/documents/tannin.pdf
Disodium EDTA
No known risks
Disodium EDTA is a chelating agent used to improve formula stability and performance; it is considered low concern in topical cosmetic use, with no known pregnancy or breastfeeding risks at typical concentrations.
Sources: CIR; EU/UK Cosmetics Regulation
Sodium Phytate
No known risks
Chelating agent used to improve formula stability. Used at low levels and not associated with pregnancy-specific concerns.
Sources: European cosmetics regulatory framework
Full recorded ingredient list
Water, Melaleuca Alternifolia Leaf Water, Propanediol, Glycerin, 1,2-Hexanediol, Hydrogenated Polydecene, Vinyldimethicone, C14-22 Alcohols, Niacinamide, Caprylic/Capric Triglyceride, Panthenol, Dicaprylyl Carbonate, Butylene Glycol, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Caprylyl Methicone, Polymethylsilsesquioxane, C12-20 Alkyl Glucoside, Hydroxyacetophenone, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Polyquaternium-51, Ethylhexylglycerin, Tromethamine, Sodium Hyaluronate, Sodium Stearoyl Glutamate, Coptis Japonica Root Extract, Centella Asiatica Leaf Water, Beta-Glucan, Resveratrol, Hydrolyzed Hyaluronic Acid, Camellia Sinensis Leaf Water, Tocopherol, Madecassoside, Sodium Dna, Centella Asiatica Extract, Ceramide NP, Tannic Acid, Disodium EDTA, Sodium Phytate
Ingredient ratings refreshed 1 October 2026. Formulas vary by market and can change. Always compare with your packaging.
Questions about this assessment
Why does Dr. Althea 345 Relief Cream have a Low risk rating?
The recorded formula includes 4 ingredient entries with risk flags: Vinyldimethicone (Low risk), Coptis Japonica Root Extract (Low risk), Resveratrol (Low risk), plus others listed in the breakdown. These are ingredient-level flags; they do not replace the stored product assessment or account for every formulation detail. The product score is a stored assessment, not a clinical safety guarantee.
Does this assessment cover injectable PDRN treatments?
No. The recorded ingredient list includes a DNA ingredient used in a topical cosmetic. This page assesses that recorded cosmetic formula, not injections, a clinic procedure or every product sold as PDRN. Check the individual ingredient entry below for its available rating and evidence.
Has every ingredient in Dr. Althea 345 Relief Cream been assessed?
38 of 38 ingredient entries on this page have a recorded score, evidence summary and source text. That describes documentation coverage, not proof that the finished formula has been clinically tested during pregnancy.
Does this assessment apply to my Dr. Althea 345 Relief Cream?
Only if the ingredient list on your packaging matches the recorded formula shown here. Formulas can differ by market and change over time. Compare the full list, not just the product name; report a mismatch if it differs.
Does this pregnancy assessment also establish breastfeeding suitability?
No. This page presents a pregnancy-focused product assessment. Do not infer a breastfeeding conclusion from its score or label; breastfeeding requires a separate assessment of the formula and how it is used.
