Alpha-Arbutin
Medium RiskAlpha-arbutin is a skin-brightening ingredient that inhibits tyrosinase and can be viewed as a glycosylated hydroquinone. The central safety signal is potential hydroquinone release/contamination plus systemic exposure from dermal absorption and aggregate exposure across multiple product types. Pregnancy-specific human outcome data for topical cosmetic exposure are limited; the medium-risk signal is hydroquinone-related concern and uncertainty rather than a robust pregnancy-specific safety dataset.
Sources: SCCS/1642/22: Alpha-arbutin and beta-arbutin in cosmetics https://health.ec.europa.eu/publications/safety-alpha-arbutin-and-beta-arbutin-cosmetic-products_en



