La Roche-Posay
La Roche-Posay Cicaplast Baume B5+
Low risk79/100
La Roche-Posay
Anthelios Uvmune 400 Invisible Fluid SPF50+
Sunscreens
This formula needs extra consideration during pregnancy. Review the flagged ingredients with your healthcare professional.
25 of 26 ingredients rated1 not assessed
Is it suitable during pregnancy?
MamaSkin rates the recorded formula for La Roche-Posay Anthelios Uvmune 400 Invisible Fluid SPF50+ as Medium risk (55/100). Discuss the flagged ingredients with a qualified healthcare professional before using this formula during pregnancy.
Why this rating?
The recorded formula includes 3 ingredient entries with risk flags: Butyl Methoxydibenzoylmethane (Medium risk), Ethylhexyl Salicylate (Low risk), Triethanolamine (Low risk). These are ingredient-level flags; they do not replace the stored product assessment or account for every formulation detail.
25 of 26 ingredient entries on this page have a recorded score, evidence summary and source text. 1 entry does not have all of those fields. Unmatched or unrated entries are marked Not assessed in grey; missing evidence does not establish safety.
How we assess productsIngredient breakdown
The recorded formula, with evidence behind each rating. Unmatched ingredients are marked Not assessed in grey.
Ingredient ratings and evidence
Higher-risk flags first. Open an ingredient for evidence.
Butyl Methoxydibenzoylmethane
Medium risk
Butyl methoxydibenzoylmethane (avobenzone) is a UVA filter used in sunscreens. Reviews note potential endocrine-related signals for several organic UV filters, but data are often not sufficient to establish endocrine disruption, and systemic exposure depends on formulation and use pattern. Pregnancy-specific human outcome data for topical exposure are limited; the key signal is uncertainty around systemic/endocrine effects rather than a well-defined pregnancy outcome dataset.
Sources: TGA: Safety review of seven active sunscreen ingredients https://www.tga.gov.au/resources/publication/corporate-reports/safety-review-seven-active-sunscreen-ingredients
Ethylhexyl Salicylate
Low risk
Ethylhexyl salicylate (octisalate) is an organic UV-B filter with measurable topical absorption. A CIR review records a rat oral reproductive/developmental study with dose-related post-implantation loss and smaller litters at 80 and 250 mg/kg/day (NOAEL 25 mg/kg/day); those repeated oral doses do not model intact-skin cosmetic exposure. The same review found relatively low human-skin permeability and concluded ethylhexyl salicylate safe in the assessed cosmetic uses. A ToxCast-to-human-exposure comparison found the most sensitive in-vitro endocrine response at about 16.5 micromolar versus about 0.023 micromolar maximal-use human plasma exposure, roughly 700-fold lower. FDA still requests additional sunscreen safety data, and pregnancy-outcome data are limited; MotherToBaby reports no proven increased pregnancy risk. MamaSkin therefore uses Low Risk to surface absorption and the evidence gap without treating remote high-dose animal findings as proof that typical topical use should be avoided.
Sources: CIR 2019 Final Report: Amended Safety Assessment of Salicylic Acid and Salicylates https://www.cir-safety.org/sites/default/files/salicy042019FAR.pdf, Toxicological Sciences 2023: ToxCast/Tox21 endocrine activity compared with human plasma exposure https://academic.oup.com/toxsci/article/196/1/25/7240499, FDA: OTC sunscreen proposed-order Q&A https://www.fda.gov/drugs/understanding-over-counter-medicines/questions-and-answers-fda-posts-deemed-final-order-and-proposed-order-over-counter-sunscreen, Matta et al. JAMA 2020 maximal-use sunscreen absorption trial https://jamanetwork.com/journals/jama/fullarticle/2759002, MotherToBaby: Screening Your Sunscreen During Pregnancy https://mothertobaby.org/baby-blog/screening-your-sunscreen-during-pregnancy/
Triethanolamine
Low risk
Triethanolamine (TEA) is an alkanolamine used as a pH adjuster and surfactant in cosmetics. The main practical concerns are skin/eye irritation at higher concentrations and the potential formation of nitrosamines if formulated with nitrosating agents (a formulation/impurity-control issue). It is not a typical pregnancy-specific concern at cosmetic use levels; overall risk is primarily local irritation/sensitisation in susceptible users.
Sources: CIR: Triethanolamine ingredient safety information https://www.cir-safety.org/ingredient/triethanolamine
Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate
Not assessed
No matched ingredient rating is available yet. Not assessed does not mean safe or unsafe.
Water
No known risks
Water (Aqua) is the standard purified water used as a cosmetic solvent. It has no pregnancy-specific risk in normal topical use.
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/Water, https://single-market-economy.ec.europa.eu/sectors/cosmetics/cosmetic-ingredient-database/cosing-glossary-ingredients_en
Show all 26 ingredients
Alcohol Denat.
No known risks
Volatile solvent used to improve texture, drying time, and penetration in some formulas. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed; the main practical issue is dryness, stinging, or barrier disruption in some users.
Sources: CIR: Safety Assessment of SD Alcohol 40, Benzyl Alcohol, and Denatured Alcohol in Cosmetic Products; EU CosIng / cosmetics regulatory inventory
Triethyl Citrate
No known risks
An ester of citric acid and ethanol used as a solvent, deodorant ingredient and fragrance carrier. Cosmetic safety reviewers assessed triethyl citrate with citric acid, citrate salts and alkyl citrate esters and concluded that the group is safe in current cosmetic use when formulated to avoid irritation. Triethyl citrate is also an established food-use substance, and no pregnancy-specific concern is identified for normal topical cosmetic exposure.
Sources: CIR: Safety Assessment of Citric Acid, Inorganic Citrate Salts, and Alkyl Citrate Esters https://pubmed.ncbi.nlm.nih.gov/24861367/
Diisopropyl Sebacate
No known risks
An ester of a dicarboxylic acid used as an emollient, solvent or texture agent. Cosmetic safety reviewers concluded that the assessed alkyl dicarboxylic acid esters are safe in current practices of use and concentration. No pregnancy-specific concern was identified for normal topical exposure.
Sources: CIR: Safety Assessment of Alkyl Dicarboxylic Acid Esters as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=d8d3785f-8e74-ec11-8943-0022482f06a6
Silica
No known risks
Mineral absorbent and texture aid used to mattify and improve slip. Reviewed cosmetic safety sources support normal topical cosmetic use; this assessment does not cover deliberate inhalation of loose powder.
Sources: CIR: Safety Assessment of Silica and Silicates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine
No known risks
Modern broad-spectrum UV filter (often known as Tinosorb S). It has a high molecular weight and is formulated to remain mainly in the outer skin layers, with very low systemic absorption at cosmetic use levels. EU regulatory assessments and independent risk–benefit reviews have evaluated this filter as safe up to 10% in sunscreens, with no specific reproductive or developmental toxicity signals identified in animals or humans at permitted concentrations.
Sources: European Union Cosmetic Products Regulation (Annex VI): Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine listed as an approved UV filter up to 10% in cosmetic products. Mikkelsen SH et al. “Survey and health assessment of UV filters” – Danish EPA, 2015: includes Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine and notes low systemic exposure at approved use levels.
Ethylhexyl Triazone
No known risks
UV filter used in sunscreens and day products to help absorb UVB radiation. Reviewed cosmetic safety and regulatory sources support current cosmetic use within applicable concentration limits, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.
Sources: EU CosIng Annex VI / UV filters; EU scientific opinion on Ethylhexyl Triazone (Uvinul T 150)
Glycerin
No known risks
Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation
Propanediol
No known risks
Solvent and humectant used to improve texture and ingredient solubility. Low systemic exposure expected from topical cosmetic use.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
C12-22 Alkyl Acrylate/Hydroxyethylacrylate Copolymer
No known risks
C12 22 Alkyl Acrylate/hydroxyethylacrylate Copolymer is a cosmetic polymer, film former or high-molecular-weight texture aid. Systemic dermal absorption is expected to be limited when manufactured with appropriate residual-monomer and impurity controls. No pregnancy-specific concern was identified for normal cosmetic use; avoid inhaling airborne powder or spray droplets.
Sources: CIR polymer safety assessments and Quick Reference Table https://www.cir-safety.org/supplementaldoc/quick-reference-table-december-2025; European Commission CosIng ingredient inventory
Sodium Citrate
No known risks
Buffering and chelating ingredient used to control pH and formulation stability. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Safety Assessment of Citric Acid, Inorganic Citrate Salts, and Alkyl Citrate Esters as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
Perlite
No known risks
An insoluble mineral or elemental particle used for optical effects, absorbency or cosmetic texture. Meaningful systemic exposure through intact skin is expected to be low. No pregnancy- or reproductive-toxicity signal was identified for normal topical cosmetic use. Particle size, source purity, metal impurities and inhalation of airborne powder remain formulation-specific considerations, and local contact allergy is possible with gold.
Sources: European Commission CosIng ingredient inventory; SCCS guidance on the safety assessment of nanomaterials in cosmetics https://health.ec.europa.eu/scientific-committees/scientific-committee-consumer-safety-sccs_en; published cosmetic and dermatology literature for gold, diamond powder and perlite.
Tocopherol
No known risks
Vitamin E antioxidant used to protect oils and support the skin barrier. Not associated with pregnancy-specific concerns at cosmetic exposure.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
Caprylic/Capric Triglyceride
No known risks
Common emollient derived from fatty acids and glycerin. Used to soften skin and improve texture without pregnancy-specific concerns.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
No known risks
Polymer thickener and stabiliser used in creams and sunscreens. Low systemic exposure expected.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
Caprylyl Glycol
No known risks
Humectant and preservative booster used to support product stability. Low systemic exposure expected from topical cosmetic use.
Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)
Citric Acid
No known risks
pH adjuster used in small amounts to maintain product stability. Not associated with pregnancy-specific concerns.
Sources: Scientific Committee on Consumer Safety (EU); European cosmetics regulatory framework
Diethylamino Hydroxybenzoyl Hexyl Benzoate
No known risks
Modern UVA filter (often called Uvinul A+ or DHHB). Regulatory assessments have repeatedly evaluated this filter as safe in cosmetic products at concentrations up to 10%. The most recent SCCS advice focuses on controlling a manufacturing impurity (DnHexP) rather than on new toxicity of DHHB itself. Human biomonitoring data indicate low systemic exposure from normal sunscreen use, and current reviews do not identify specific reproductive or developmental toxicity signals at approved concentrations.
Sources: SCCP opinion referenced in Directive 2008/123/EC: concludes that Diethylamino Hydroxybenzoyl Hexyl Benzoate used at a maximum of 10% in cosmetic (including sunscreen) products does not pose a risk to the consumer. Regulatory summaries (e.g. CosLaw and CIRS Group updates, 2025) reviewing the SCCS DHHB opinion and reiterating that DHHB remains permitted up to 10% in EU cosmetics when impurity limits are respected.
Drometrizole Trisiloxane
No known risks
Organic UVA/UVB filter used in sunscreens, also known as Mexoryl XL. Cosmetic safety and regulatory sources support use within applicable concentration limits, with no pregnancy- or breastfeeding-specific topical concern identified in the sources reviewed.
Sources: EU CosIng Annex VI / UV filters; SCCS / European Commission cosmetic UV filter safety assessments; PubMed
Hydroxyethylcellulose
No known risks
Cellulose-derived thickener used to build viscosity and improve texture. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR Quick Reference Table / ingredient status (Hydroxyethylcellulose, Final Report 03/2009); EU CosIng / cosmetics regulatory inventory
Terephthalylidene Dicamphor Sulfonic Acid
No known risks
Organic UVA filter used in sunscreens, also known as Ecamsule or Mexoryl SX. Cosmetic safety and regulatory sources support use within applicable concentration limits, with no pregnancy- or breastfeeding-specific topical concern identified in the sources reviewed.
Sources: EU CosIng Annex VI / UV filters; SCCS / European Commission cosmetic UV filter safety assessments; PubMed
Trisodium Ethylenediamine Disuccinate
No known risks
Chelating ingredient used to improve formula stability by binding trace metals. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.
Sources: CIR cosmetic ingredient safety references for chelating agents; EU CosIng / cosmetics regulatory inventory
Full recorded ingredient list
Water, Alcohol Denat., Triethyl Citrate, Diisopropyl Sebacate, Silica, Ethylhexyl Salicylate, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Ethylhexyl Triazone, Butyl Methoxydibenzoylmethane, Glycerin, Propanediol, C12-22 Alkyl Acrylate/Hydroxyethylacrylate Copolymer, Sodium Citrate, Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate, Perlite, Tocopherol, Caprylic/Capric Triglyceride, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylyl Glycol, Citric Acid, Diethylamino Hydroxybenzoyl Hexyl Benzoate, Drometrizole Trisiloxane, Hydroxyethylcellulose, Terephthalylidene Dicamphor Sulfonic Acid, Triethanolamine, Trisodium Ethylenediamine Disuccinate
Ingredient ratings refreshed 1 October 2026. Formulas vary by market and can change. Always compare with your packaging.
Questions about this assessment
Why does La Roche-Posay Anthelios Uvmune 400 Invisible Fluid SPF50+ have a Medium risk rating?
The recorded formula includes 3 ingredient entries with risk flags: Butyl Methoxydibenzoylmethane (Medium risk), Ethylhexyl Salicylate (Low risk), Triethanolamine (Low risk). These are ingredient-level flags; they do not replace the stored product assessment or account for every formulation detail. Incomplete ingredient documentation does not establish safety; see the coverage answer and grey entries below.
Is the MamaSkin score a measure of SPF or sun protection?
No. The score and risk band describe MamaSkin's pregnancy-focused ingredient screening of this recorded formula. They do not measure SPF, UVA protection, water resistance or whether you have applied enough sunscreen. Use the protection and application instructions on your exact packaging, and review the ingredient flags separately.
Has every ingredient in La Roche-Posay Anthelios Uvmune 400 Invisible Fluid SPF50+ been assessed?
25 of 26 ingredient entries on this page have a recorded score, evidence summary and source text. 1 entry does not have all of those fields. Unmatched or unrated entries are marked Not assessed in grey; missing evidence does not establish safety.
Does this assessment apply to my La Roche-Posay Anthelios Uvmune 400 Invisible Fluid SPF50+?
Only if the ingredient list on your packaging matches the recorded formula shown here. Formulas can differ by market and change over time. Compare the full list, not just the product name; report a mismatch if it differs.
Does this pregnancy assessment also establish breastfeeding suitability?
No. This page presents a pregnancy-focused product assessment. Do not infer a breastfeeding conclusion from its score or label; breastfeeding requires a separate assessment of the formula and how it is used.
