Safety score
Pregnancy-focused assessment
One or more ingredients have a low-risk flag in MamaSkin's current assessment. Review the notes and your own circumstances.
Formula and assessment check
Ingredient safety review updated 9 December 2025. Product formulas can change, so compare the ingredients shown here with the packaging you have.
Report a formula mismatchMamaSkin assessment · 9 December 2025
MamaSkin currently classifies MediCube One Day Zero Exosome Shot as Low risk, with a stored score of 78/100. This is a precautionary classification, not an unqualified pregnancy-safe recommendation. Read the ingredient context and any manual-review explanation below.
The recorded formula includes 2 ingredient entries with risk flags: Betaine Salicylate (Low risk), Gluconolactone (Low risk). These are ingredient-level flags; they do not replace the stored product assessment or account for every formulation detail.
24 of 27 ingredient entries on this page have a recorded score, evidence summary and source text. 3 entries do not have all of those fields. Unmatched entries retain the default No known risks label but are not independently assessed here; missing evidence does not establish safety.
See how the listed formula falls across MamaSkin's pregnancy-focused risk bands.
25
No known risks
2
Low risk
0
Medium risk
0
High risk
Ingredients with a higher risk flag appear first, followed by the rest of the formula.
Ester form of salicylic acid; hydrolyses to SA, low-strength topical use shows negligible systemic absorption - chemical peels ≥30 % should be avoided.
Sources: MotherToBaby: Topical acne treatments including salicylic acid https://www.ncbi.nlm.nih.gov/books/NBK582985/
Polyhydroxy acid (PHA) used as a gentle exfoliant/humectant; generally less irritating than AHAs due to lower penetration. Considered safe as used in cosmetics, with no pregnancy-specific contraindications identified at topical cosmetic concentrations.
Sources: MotherToBaby: Topical acne treatments in pregnancy and breastfeeding https://www.ncbi.nlm.nih.gov/books/NBK582985/
Water (aqua) is the purified solvent used as the base of many cosmetics. MamaSkin classifies plain water as No known risks for normal topical use. Cosmetic water quality must be controlled to prevent contamination; this entry does not cover botanical waters or establish the safety of the finished formula.
Sources: Personal Care Products Council, CosmeticsInfo: Water https://www.cosmeticsinfo.org/ingredient/water/; FDA: Cosmetic Ingredient Names (Water/Aqua identity) https://www.fda.gov/cosmetics/cosmetics-labeling/cosmetic-ingredient-names
Dipropylene glycol is used as a solvent and carrier in cosmetics; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations.
Sources: CIR; EU/UK Cosmetics Regulation
Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation
Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.
Sources: CIR; EU/UK Cosmetics Regulation
Niacinamide (vitamin B3) is widely used for barrier support and tone/texture benefits, and is generally considered safe in pregnancy and breastfeeding when used topically at cosmetic concentrations.
Sources: CIR; EU/UK Cosmetics Regulation
Polymer used for texture and absorbency. Large-molecule ingredient with low systemic exposure.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
Lightweight emollient ester used to soften skin and improve glide. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Amended Safety Assessment of Alkyl Esters as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
A PEG, PPG or alkoxylated emulsifier or solubiliser used to stabilise a cosmetic formula. CIR assessments of related PEG/PPG materials support use in current cosmetic practices. No pregnancy-specific hazard signal was identified for normal topical exposure; cosmetic-grade manufacture should control ethylene oxide, propylene oxide and 1,4-dioxane residues.
Sources: CIR safety assessments of PEGs, PPGs, Alkyl PEG/PPG Ethers and PEG Fatty Acid Esters; FDA information on 1,4-dioxane in cosmetics https://www.fda.gov/cosmetics/potential-contaminants-cosmetics/14-dioxane-cosmetics; CIR December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf.
Synthetic hydrocarbon emollient used to improve slip, cushion and moisture feel. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.
Sources: CIR cosmetic ingredient safety references for polydecenes/hydrocarbon emollients; EU CosIng / cosmetics regulatory inventory
Preservative booster and skin-conditioning agent. Considered safe for cosmetic use with low systemic exposure when used as intended.
Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)
Skin-conditioning ingredient commonly used in leave-on skincare. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Safety Assessment of Adenosine Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
This glucose-derived nonionic surfactant or emulsifier is used in cleansers and emulsions. The Cosmetic Ingredient Review concluded that alkyl glucosides are safe in current cosmetic use when formulated to be non-irritating; sensitive skin can still react to surfactants.
Sources: CIR: Safety Assessment of Decyl Glucoside and Other Alkyl Glucosides as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=9810a771-8e74-ec11-8943-0022482f06a6
Disodium EDTA is a chelating agent used to improve formula stability and performance; it is considered low concern in topical cosmetic use, with no known pregnancy or breastfeeding risks at typical concentrations.
Sources: CIR; EU/UK Cosmetics Regulation
Panthenol (pro-vitamin B5) is used for soothing and barrier support and is generally well tolerated, with no known pregnancy or breastfeeding concerns in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation
calcium silicate is a cosmetic formulation, mineral, sugar-derived or organic-acid ingredient. Available identity, use and related safety evidence did not identify a pregnancy-specific concern for normal topical cosmetic exposure. Cosmetic-grade purity and ordinary irritation precautions remain applicable.
Sources: CIR ingredient and related-family assessments; European Commission CosIng; ECHA substance information where applicable
Kudzu root extract is a botanical skin-conditioning ingredient that may contain isoflavones including puerarin, daidzin and daidzein. Oral supplement exposure is not equivalent to the small amount used topically in a finished cosmetic. No evidence establishing a pregnancy or breastfeeding hazard from normal topical cosmetic use was identified.
Sources: PubMed: Chemical constituents of Pueraria lobata root extracts, including puerarin and isoflavones https://pubmed.ncbi.nlm.nih.gov/41900064/; European Commission CosIng ingredient inventory. No ingredient-specific topical pregnancy studies were identified.
A longleaf-pine leaf extract used for skin conditioning and fragrance. No pregnancy- or breastfeeding-specific hazard was identified for normal topical cosmetic exposure. Direct ingredient-specific pregnancy studies were not identified, so this assessment does not extend to oral supplements or medicinal use.
Sources: European Commission CosIng ingredient inventory; Cosmetic Ingredient Review botanical safety-assessment framework and relevant ingredient-family assessments. No ingredient-specific human pregnancy study of normal topical cosmetic use was identified.
An evening-primrose flower extract used for skin conditioning. No pregnancy- or breastfeeding-specific hazard was identified for normal topical cosmetic exposure. Direct ingredient-specific pregnancy studies were not identified, so this assessment does not extend to oral supplements or medicinal use.
Sources: European Commission CosIng ingredient inventory; Cosmetic Ingredient Review botanical safety-assessment framework and relevant ingredient-family assessments. No ingredient-specific human pregnancy study of normal topical cosmetic use was identified.
A Japanese elm root extract used as a skin-conditioning botanical. No pregnancy- or breastfeeding-specific hazard was identified for normal topical cosmetic exposure. Direct ingredient-specific pregnancy studies were not identified, so this assessment does not extend to oral supplements or medicinal use.
Sources: European Commission CosIng ingredient inventory; Cosmetic Ingredient Review botanical safety-assessment framework and relevant ingredient-family assessments. No ingredient-specific human pregnancy study of normal topical cosmetic use was identified.
sodium silicate is a cosmetic formulation, mineral, sugar-derived or organic-acid ingredient. Available identity, use and related safety evidence did not identify a pregnancy-specific concern for normal topical cosmetic exposure. Cosmetic-grade purity and ordinary irritation precautions remain applicable.
Sources: CIR ingredient and related-family assessments; European Commission CosIng; ECHA substance information where applicable
pH adjuster used in small amounts to maintain product stability. Not associated with pregnancy-specific concerns.
Sources: Scientific Committee on Consumer Safety (EU); European cosmetics regulatory framework
Formulations can change without notice. For the most accurate result, compare this list with your packaging and scan the exact ingredient label in MamaSkin when you repurchase.
24 of 27 ingredient entries on this page have a recorded score, evidence summary and source text. 3 entries do not have all of those fields. Unmatched entries retain the default No known risks label but are not independently assessed here; missing evidence does not establish safety.
Only if the ingredient list on your packaging matches the recorded formula shown here. Formulas can differ by market and change over time. Compare the full list, not just the product name; report a mismatch if it differs.
No. This page presents a pregnancy-focused product assessment. Do not infer a breastfeeding conclusion from its score or label; breastfeeding requires a separate assessment of the formula and how it is used.
The risk band is the primary conclusion. The score adds detail within that band and should not be used to compare products as if a one-point difference were clinically meaningful.
MamaSkin provides pregnancy-focused information, not medical advice. Your midwife, GP, pharmacist or dermatologist should take priority when your circumstances differ from typical cosmetic use.
