MediCube
MediCube Collagen Jelly Cream
Low risk76/100
MediCube
One Day Zero Exosome Shot
Some ingredients carry a low-risk flag. Read the formulation context before deciding.
24 of 27 ingredients rated3 not assessed
Is it suitable during pregnancy?
MamaSkin rates the recorded formula for MediCube One Day Zero Exosome Shot as Low risk (78/100). Review the ingredient context and any manual-review explanation before deciding.
Why this rating?
The recorded formula includes 2 ingredient entries with risk flags: Betaine Salicylate (Low risk), Gluconolactone (Low risk). These are ingredient-level flags; they do not replace the stored product assessment or account for every formulation detail.
24 of 27 ingredient entries on this page have a recorded score, evidence summary and source text. 3 entries do not have all of those fields. Unmatched or unrated entries are marked Not assessed in grey; missing evidence does not establish safety.
How we assess productsIngredient breakdown
The recorded formula, with evidence behind each rating. Unmatched ingredients are marked Not assessed in grey.
Ingredient ratings and evidence
Higher-risk flags first. Open an ingredient for evidence.
Betaine Salicylate
Low risk
Ester form of salicylic acid; hydrolyses to SA, low-strength topical use shows negligible systemic absorption - chemical peels ≥30 % should be avoided.
Sources: MotherToBaby: Topical acne treatments including salicylic acid https://www.ncbi.nlm.nih.gov/books/NBK582985/
Gluconolactone
Low risk
Polyhydroxy acid (PHA) used as a gentle exfoliant/humectant; generally less irritating than AHAs due to lower penetration. Considered safe as used in cosmetics, with no pregnancy-specific contraindications identified at topical cosmetic concentrations.
Sources: MotherToBaby: Topical acne treatments in pregnancy and breastfeeding https://www.ncbi.nlm.nih.gov/books/NBK582985/
Hydrolyzed Sponge
Not assessed
Sponge-spicule materials may increase irritation and the absorption of other ingredients, but this label does not define their composition or physical properties. No reproductive evidence was located for the material itself, so a pregnancy risk band cannot yet be assigned.
Sources: https://pubmed.ncbi.nlm.nih.gov/28763230/, https://pubmed.ncbi.nlm.nih.gov/35034416/, https://pubmed.ncbi.nlm.nih.gov/34959402/, https://pubmed.ncbi.nlm.nih.gov/40103747/
Lactobacillus Extracellular Vesicles
Not assessed
No matched ingredient rating is available yet. Not assessed does not mean safe or unsafe.
Campsis Grandiflora Flower Extract
Not assessed
No matched ingredient rating is available yet. Not assessed does not mean safe or unsafe.
Show all 27 ingredients
Water
No known risks
Water (Aqua) is the standard purified water used as a cosmetic solvent. It has no pregnancy-specific risk in normal topical use.
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/Water, https://single-market-economy.ec.europa.eu/sectors/cosmetics/cosmetic-ingredient-database/cosing-glossary-ingredients_en
Dipropylene Glycol
No known risks
Dipropylene glycol is used as a solvent and carrier in cosmetics; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations.
Sources: CIR; EU/UK Cosmetics Regulation
Glycerin
No known risks
Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation
Butylene Glycol
No known risks
Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
1,2-Hexanediol
No known risks
1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.
Sources: CIR; EU/UK Cosmetics Regulation
Niacinamide
No known risks
Niacinamide (vitamin B3) is widely used for barrier support and tone/texture benefits, and is generally considered safe in pregnancy and breastfeeding when used topically at cosmetic concentrations.
Sources: CIR; EU/UK Cosmetics Regulation
Sodium Polyacrylate
No known risks
Polymer used for texture and absorbency. Large-molecule ingredient with low systemic exposure.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
Ethylhexyl Palmitate
No known risks
Lightweight emollient ester used to soften skin and improve glide. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Amended Safety Assessment of Alkyl Esters as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
C12-14 Alketh-12
No known risks
A PEG, PPG or alkoxylated emulsifier or solubiliser used to stabilise a cosmetic formula. CIR assessments of related PEG/PPG materials support use in current cosmetic practices. No pregnancy-specific hazard signal was identified for normal topical exposure; cosmetic-grade manufacture should control ethylene oxide, propylene oxide and 1,4-dioxane residues.
Sources: CIR safety assessments of PEGs, PPGs, Alkyl PEG/PPG Ethers and PEG Fatty Acid Esters; FDA information on 1,4-dioxane in cosmetics https://www.fda.gov/cosmetics/potential-contaminants-cosmetics/14-dioxane-cosmetics; CIR December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf.
Hydrogenated Polydecene
No known risks
Synthetic hydrocarbon emollient used to improve slip, cushion and moisture feel. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.
Sources: CIR cosmetic ingredient safety references for polydecenes/hydrocarbon emollients; EU CosIng / cosmetics regulatory inventory
Ethylhexylglycerin
No known risks
Preservative booster and skin-conditioning agent. Considered safe for cosmetic use with low systemic exposure when used as intended.
Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)
Adenosine
No known risks
Skin-conditioning ingredient commonly used in leave-on skincare. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Safety Assessment of Adenosine Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
Caprylyl/Capryl Glucoside
No known risks
This glucose-derived nonionic surfactant or emulsifier is used in cleansers and emulsions. The Cosmetic Ingredient Review concluded that alkyl glucosides are safe in current cosmetic use when formulated to be non-irritating; sensitive skin can still react to surfactants.
Sources: CIR: Safety Assessment of Decyl Glucoside and Other Alkyl Glucosides as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=9810a771-8e74-ec11-8943-0022482f06a6
Disodium EDTA
No known risks
Disodium EDTA is a chelating agent used to improve formula stability and performance; it is considered low concern in topical cosmetic use, with no known pregnancy or breastfeeding risks at typical concentrations.
Sources: CIR; EU/UK Cosmetics Regulation
Panthenol
No known risks
Panthenol (pro-vitamin B5) is used for soothing and barrier support and is generally well tolerated, with no known pregnancy or breastfeeding concerns in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation
Calcium Silicate
No known risks
calcium silicate is a cosmetic formulation, mineral, sugar-derived or organic-acid ingredient. Available identity, use and related safety evidence did not identify a pregnancy-specific concern for normal topical cosmetic exposure. Cosmetic-grade purity and ordinary irritation precautions remain applicable.
Sources: CIR ingredient and related-family assessments; European Commission CosIng; ECHA substance information where applicable
Pueraria Lobata Root Extract
No known risks
Kudzu root extract is a botanical skin-conditioning ingredient that may contain isoflavones including puerarin, daidzin and daidzein. Oral supplement exposure is not equivalent to the small amount used topically in a finished cosmetic. No evidence establishing a pregnancy or breastfeeding hazard from normal topical cosmetic use was identified.
Sources: PubMed: Chemical constituents of Pueraria lobata root extracts, including puerarin and isoflavones https://pubmed.ncbi.nlm.nih.gov/41900064/; European Commission CosIng ingredient inventory. No ingredient-specific topical pregnancy studies were identified.
Pinus Palustris Leaf Extract
No known risks
A longleaf-pine leaf extract used for skin conditioning and fragrance. No pregnancy- or breastfeeding-specific hazard was identified for normal topical cosmetic exposure. Direct ingredient-specific pregnancy studies were not identified, so this assessment does not extend to oral supplements or medicinal use.
Sources: European Commission CosIng ingredient inventory; Cosmetic Ingredient Review botanical safety-assessment framework and relevant ingredient-family assessments. No ingredient-specific human pregnancy study of normal topical cosmetic use was identified.
Oenothera Biennis Flower Extract
No known risks
An evening-primrose flower extract used for skin conditioning. No pregnancy- or breastfeeding-specific hazard was identified for normal topical cosmetic exposure. Direct ingredient-specific pregnancy studies were not identified, so this assessment does not extend to oral supplements or medicinal use.
Sources: European Commission CosIng ingredient inventory; Cosmetic Ingredient Review botanical safety-assessment framework and relevant ingredient-family assessments. No ingredient-specific human pregnancy study of normal topical cosmetic use was identified.
Ulmus Davidiana Root Extract
No known risks
A Japanese elm root extract used as a skin-conditioning botanical. No pregnancy- or breastfeeding-specific hazard was identified for normal topical cosmetic exposure. Direct ingredient-specific pregnancy studies were not identified, so this assessment does not extend to oral supplements or medicinal use.
Sources: European Commission CosIng ingredient inventory; Cosmetic Ingredient Review botanical safety-assessment framework and relevant ingredient-family assessments. No ingredient-specific human pregnancy study of normal topical cosmetic use was identified.
Sodium Silicate
No known risks
sodium silicate is a cosmetic formulation, mineral, sugar-derived or organic-acid ingredient. Available identity, use and related safety evidence did not identify a pregnancy-specific concern for normal topical cosmetic exposure. Cosmetic-grade purity and ordinary irritation precautions remain applicable.
Sources: CIR ingredient and related-family assessments; European Commission CosIng; ECHA substance information where applicable
Citric Acid
No known risks
pH adjuster used in small amounts to maintain product stability. Not associated with pregnancy-specific concerns.
Sources: Scientific Committee on Consumer Safety (EU); European cosmetics regulatory framework
Full recorded ingredient list
Water, Dipropylene Glycol, Glycerin, Butylene Glycol, 1,2-Hexanediol, Niacinamide, Sodium Polyacrylate, Ethylhexyl Palmitate, Hydrolyzed Sponge, C12-14 Alketh-12, Hydrogenated Polydecene, Ethylhexylglycerin, Adenosine, Caprylyl/Capryl Glucoside, Disodium EDTA, Panthenol, Calcium Silicate, Lactobacillus Extracellular Vesicles, Campsis Grandiflora Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Oenothera Biennis Flower Extract, Ulmus Davidiana Root Extract, Sodium Silicate, Betaine Salicylate, Citric Acid, Gluconolactone
Ingredient ratings refreshed 1 October 2026. Formulas vary by market and can change. Always compare with your packaging.
Questions about this assessment
Why does MediCube One Day Zero Exosome Shot have a Low risk rating?
The recorded formula includes 2 ingredient entries with risk flags: Betaine Salicylate (Low risk), Gluconolactone (Low risk). These are ingredient-level flags; they do not replace the stored product assessment or account for every formulation detail. Incomplete ingredient documentation does not establish safety; see the coverage answer and grey entries below.
Has the spicule ingredient in this formula been assessed?
Hydrolyzed Sponge appears in the recorded formula and is marked Not assessed in grey. The stored product score does not fill that ingredient-level gap or establish pregnancy suitability for the finished spicule formula. Read the other ingredient entries too; do not treat a peptide or barrier-care claim as an assessment of the delivery system.
Has every ingredient in MediCube One Day Zero Exosome Shot been assessed?
24 of 27 ingredient entries on this page have a recorded score, evidence summary and source text. 3 entries do not have all of those fields. Unmatched or unrated entries are marked Not assessed in grey; missing evidence does not establish safety.
Does this assessment apply to my MediCube One Day Zero Exosome Shot?
Only if the ingredient list on your packaging matches the recorded formula shown here. Formulas can differ by market and change over time. Compare the full list, not just the product name; report a mismatch if it differs.
Does this pregnancy assessment also establish breastfeeding suitability?
No. This page presents a pregnancy-focused product assessment. Do not infer a breastfeeding conclusion from its score or label; breastfeeding requires a separate assessment of the formula and how it is used.
