Safety score
Pregnancy-focused assessment
One or more ingredients have a low-risk flag in MamaSkin's current assessment. Review the notes and your own circumstances.
Ingredient safety review updated 23 November 2025.
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See how the listed formula falls across MamaSkin's pregnancy-focused risk bands.
38
No known risks
2
Low risk
0
Medium risk
0
High risk
Ingredients with a higher risk flag appear first, followed by the rest of the formula.
Umbrella term for an undisclosed fragrance blend. It’s not usually a pregnancy-specific concern at normal cosmetic use levels, but the exact components and concentrations aren’t fully disclosed on the label, so we score it more conservatively. If you prefer maximum transparency (or you’re sensitive to fragrance compounds), choose fragrance-free/unscented products.
Sources: EU/UK cosmetics (fragrance allergen labelling); IFRA
DNA-derived cosmetic ingredient/label term used in topical PDRN or polynucleotide-style skincare. Topical cosmetic use is not currently treated as a known pregnancy-restricted concern, but pregnancy-specific clinical data remain limited. MamaSkin scores this conservatively as low risk to reflect the evidence gap. This assessment applies to topical cosmetic products only and does not apply to injectable or in-clinic PDRN/polynucleotide treatments. Always review co-ingredients such as retinoids, hydroquinone, high-strength acids or other pregnancy-restricted actives separately.
Sources: EU/UK cosmetics regulatory framework; EU CosIng / INCI-style cosmetic ingredient references; cosmetic supplier information for Sodium DNA / PDRN / Polydeoxyribonucleotide; peer-reviewed reviews on topical/aesthetic PDRN and polynucleotides; brand pregnancy-safety statements where available.
Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.
Sources: CIR; EU/UK Cosmetics Regulation
Dipropylene glycol is used as a solvent and carrier in cosmetics; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations.
Sources: CIR; EU/UK Cosmetics Regulation
This emollient ester improves slip and skin feel. Cosmetic Ingredient Review assessments support use in current cosmetic concentrations when formulated to be non-irritating; topical use is not identified as a pregnancy- or breastfeeding-specific concern. Some alkyl esters can increase penetration of other formula ingredients.
Sources: CIR: Safety Assessment of Alkyl Esters as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-alkyl-esters-used-cosmetics
An ethoxylated glycerin humectant used to retain moisture and improve product texture. The Cosmetic Ingredient Review assessed glycerin ethoxylates including Glycereth-26 for current cosmetic use; available evidence does not identify a pregnancy- or breastfeeding-specific concern from normal topical exposure.
Sources: CIR: Safety Assessment of Glycerin Ethoxylates https://cir-safety.org/supplementaldoc/safety-assessment-glycerin-ethoxylates-used-cosmetics
Niacinamide (vitamin B3) is widely used for barrier support and tone/texture benefits, and is generally considered safe in pregnancy and breastfeeding when used topically at cosmetic concentrations.
Sources: CIR; EU/UK Cosmetics Regulation
1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.
Sources: CIR; EU/UK Cosmetics Regulation
Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
A small glycerin polymer used as a humectant and conditioning ingredient. Cosmetic safety reviewers assessed polyglycerin-3 with diglycerin and related polyglycerins and concluded that they are safe in current practices of use and concentration. No pregnancy-specific concern was identified for normal topical use.
Sources: CIR: Safety Assessment of Diglycerin and Polyglycerins as Used in Cosmetics https://www.cir-safety.org/panelbook/safety-assessment-diglycerin-and-polyglycerin-3-6-and-10-used-cosmetics
A large synthetic polymer used to thicken and stabilise cosmetic emulsions. Related acrylate copolymers have low dermal absorption because of their molecular size, and cosmetic safety reviewers concluded that this polymer family is safe when formulas avoid irritation and residual monomers are appropriately controlled. Exact pregnancy-specific topical studies are limited, but no pregnancy-specific concern was identified for normal exposure to the finished polymer in a compliant cosmetic.
Sources: CIR: Amended Safety Assessment of Acrylates Copolymers as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment?id=c3a1aad1-8c74-ec11-8943-0022482f06a6; CIR: Final Report on Acrylates Copolymer and Related Ingredients https://cir-reports.cir-safety.org/view-attachment/?id=c9cc1a17-8e74-ec11-8943-0022482f06a6
A large, mostly insoluble polymer used as a binder, film former and texture ingredient. Cosmetic safety reviewers concluded that polyisobutene is safe in current cosmetic use; slow absorption and reproductive data on related polybutene do not indicate a pregnancy-specific concern from normal topical exposure.
Sources: CIR: Final Report on Polyisobutene and Hydrogenated Polyisobutene https://www.cir-safety.org/sites/default/files/polyene.pdf
Polymer thickener and stabiliser used in creams and sunscreens. Low systemic exposure expected.
Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)
pH adjuster and buffer used to stabilise formulations. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Safety Assessment of Tromethamine as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
A high-molecular-weight polymer used to hold water and stabilise texture. Cosmetic safety reviewers concluded that glyceryl acrylate/acrylic acid copolymer is safe in current cosmetic practices. Dermal absorption of the finished polymer is expected to be limited; residual monomers should be controlled by cosmetic manufacturing standards.
Sources: CIR: Safety Assessment of Glyceryl Acrylate/Acrylic Acid Copolymer and Glyceryl Polyacrylate https://cir-reports.cir-safety.org/view-attachment/?id=c79ac89b-d78d-055f-ba88-45f4f5a039b3
A high-molecular-weight film-forming copolymer used in hair, oral-care and skin products. Cosmetic safety reviewers concluded that PVM/MA copolymer is safe in current practices of use and concentration. Absorption of the intact polymer is expected to be limited.
Sources: CIR: Safety Assessment of PVM/MA Copolymer and Its Esters, IJT 30(Suppl. 2), 2011; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf
Preservative booster and skin-conditioning agent. Considered safe for cosmetic use with low systemic exposure when used as intended.
Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)
Humectant and preservative booster used to support product stability. Low systemic exposure expected from topical cosmetic use.
Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)
Skin-conditioning ingredient commonly used in leave-on skincare. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.
Sources: CIR: Safety Assessment of Adenosine Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory
This glucose-derived nonionic surfactant or emulsifier is used in cleansers and emulsions. The Cosmetic Ingredient Review concluded that alkyl glucosides are safe in current cosmetic use when formulated to be non-irritating; sensitive skin can still react to surfactants.
Sources: CIR: Safety Assessment of Decyl Glucoside and Other Alkyl Glucosides as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=9810a771-8e74-ec11-8943-0022482f06a6
This sorbitan fatty-acid ester is an emulsifier that helps oil and water phases remain mixed. The Cosmetic Ingredient Review concluded that sorbitan esters are safe in current cosmetic use; occasional contact reactions remain possible in sensitive users.
Sources: CIR: Safety Assessment of Sorbitan Esters as Used in Cosmetics https://www.cir-safety.org/supplementaldoc/safety-assessment-sorbitan-esters-used-cosmetics
Sodium hyaluronate (hyaluronic acid salt) is used for hydration and cushioning, with very low systemic absorption from topical use and no known pregnancy or breastfeeding concerns at cosmetic concentrations.
Sources: CIR; EU/UK Cosmetics Regulation
Disodium EDTA is a chelating agent used to improve formula stability and performance; it is considered low concern in topical cosmetic use, with no known pregnancy or breastfeeding risks at typical concentrations.
Sources: CIR; EU/UK Cosmetics Regulation
Protein-derived skin- and hair-conditioning ingredient used to support feel and hydration at the surface. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.
Sources: CIR cosmetic ingredient safety references for protein hydrolysates; EU CosIng / cosmetics regulatory inventory
Ubiquinone, also called coenzyme Q10, is an antioxidant and skin-conditioning ingredient. The Cosmetic Ingredient Review concluded that ubiquinone ingredients are safe in current cosmetic use; no pregnancy- or breastfeeding-specific concern is identified for normal topical exposure.
Sources: CIR: Safety Assessment of Ubiquinone Ingredients https://www.cir-safety.org/supplementaldoc/safety-assessment-ubiquinone-ingredients-used-cosmetics-0
A red-algae-derived extract used for skin conditioning, hydration or formula texture. Cosmetic safety reviewers concluded that the assessed red algae ingredients, including this extract, are safe in current practices of use and concentration. Cosmetic manufacturers should control naturally occurring contaminants such as heavy metals and arsenic.
Sources: CIR: Safety Assessment of Red Algae-Derived Ingredients as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=cef5b6e9-8c74-ec11-8943-0022482f06a6
Synthetic palmitoylated signal peptide used in topical anti-aging cosmetics. It is one of the better-studied cosmetic peptides, with reviewed topical literature describing controlled cosmetic studies and no pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.
Sources: Schagen SK. Topical Peptide Treatments with Effective Anti-Aging Results. Cosmetics. 2017;4(2):16. doi:10.3390/cosmetics4020016; Robinson LR et al. Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin. Int J Cosmet Sci. 2005;27(3):155-160.
Synthetic peptide used as a skin-conditioning ingredient. Reviewed cosmetic safety sources indicate no known pregnancy- or breastfeeding-specific concern in normal topical cosmetic use. Available cosmetic safety assessments conclude this ingredient is safe in the present practices of use and concentration described for cosmetics.
Sources: CIR Expert Panel, Safety Assessment of Tripeptide-1, Hexapeptide-12, their metal salts and fatty acyl derivatives, and Palmitoyl Tetrapeptide-7 as used in cosmetics, final report, 2014
Synthetic signal peptide used in topical cosmetic anti-aging and skin-conditioning formulas. Reviewed topical peptide literature describes palmitoyl tetrapeptide-7 as a cosmetic peptide with anti-inflammatory and extracellular-matrix support activity in topical formulations. No pregnancy- or breastfeeding-specific risk signal was identified for normal topical cosmetic use.
Sources: Schagen SK. Topical Peptide Treatments with Effective Anti-Aging Results. Cosmetics. 2017;4(2):16. doi:10.3390/cosmetics4020016; CIR Expert Panel safety assessment of palmitoyl oligopeptides as used in cosmetics.
Copper-binding carrier peptide also known as GHK-Cu, used topically in cosmetic skin-renewal, anti-aging, barrier-support and hair/scalp products. Reviewed literature describes topical cosmetic use and does not identify a pregnancy- or breastfeeding-specific risk signal for normal topical use. This assessment does not apply to injectable copper peptides or oral peptide/copper supplementation.
Sources: Schagen SK. Topical Peptide Treatments with Effective Anti-Aging Results. Cosmetics. 2017;4(2):16. doi:10.3390/cosmetics4020016; Pickart L et al. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018;19(7):1987. doi:10.3390/ijms19071987.
Synthetic peptide used as a skin-conditioning ingredient. Reviewed cosmetic safety sources do not indicate a known pregnancy- or breastfeeding-specific concern in normal topical cosmetic use. The available cosmetic safety assessment concluded this ingredient is safe in cosmetics at concentrations up to 0.005%; safety above that concentration was not established in the reviewed report.
Sources: CIR Expert Panel, Safety Assessment of Acetyl Hexapeptide-8 Amide as Used in Cosmetics, final report, 2021
Formulations can change without notice. For the most accurate result, compare this list with your packaging and scan the exact ingredient label in MamaSkin when you repurchase.
The risk band is the primary conclusion. The score adds detail within that band and should not be used to compare products as if a one-point difference were clinically meaningful.
MamaSkin provides pregnancy-focused information, not medical advice. Your midwife, GP, pharmacist or dermatologist should take priority when your circumstances differ from typical cosmetic use.
