MediCube Zero Pore Pad

Ester form of salicylic acid; hydrolyses to SA, low-strength topical use shows negligible systemic absorption - chemical peels ≥30 % should be avoided.

Ethyl Hexanediol is an aliphatic alcohol used mainly as a cosmetic solvent. It can be absorbed through skin. Animal studies reported developmental effects after high oral and dermal doses, but those effects occurred at doses that also caused substantial maternal toxicity. CIR concluded that the ingredient is safe as cosmetically used and later reaffirmed that conclusion. MamaSkin nevertheless classifies it as low risk under its precautionary pregnancy-screening policy; this is not a known human pregnancy contraindication at normal cosmetic exposure.

Willow bark is a salicin-containing botanical material. Its composition and delivered salicylate exposure vary by species, plant part, extraction method and concentration, so a cosmetic extract should not be treated as dose-equivalent to a stated concentration of salicylic acid. MamaSkin retains Low Risk as a conservative family policy for ordinary topical cosmetic use; this does not cover oral willow-bark medicines, concentrated preparations, large-area use or salicylate allergy.

Cassia bark extract is a cinnamon-derived botanical that may contain cinnamaldehyde and related fragrance constituents. Normal topical cosmetic exposure is not a known pregnancy contraindication, but irritation and allergic contact sensitisation are relevant. Low Risk keeps this extract consistent with MamaSkin's cinnamon and cassia family policy.

Water (aqua) is the purified solvent used as the base of many cosmetics. MamaSkin classifies plain water as No known risks for normal topical use. Cosmetic water quality must be controlled to prevent contamination; this entry does not cover botanical waters or establish the safety of the finished formula.

Solvent and humectant used to improve texture and ingredient delivery in topical cosmetic formulas. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.

pH adjuster and buffer used to stabilise formulations. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Volatile solvent used to improve texture, drying time, and penetration in some formulas. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed; the main practical issue is dryness, stinging, or barrier disruption in some users.

1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.

Panthenol (pro-vitamin B5) is used for soothing and barrier support and is generally well tolerated, with no known pregnancy or breastfeeding concerns in topical cosmetic use.

An ethoxylated glycerin humectant used to retain moisture and improve product texture. The Cosmetic Ingredient Review assessed glycerin ethoxylates including Glycereth-26 for current cosmetic use; available evidence does not identify a pregnancy- or breastfeeding-specific concern from normal topical exposure.

Polymer thickener used to stabilise emulsions. Large-molecule ingredient with low systemic absorption.

Betaine is a humectant/osmolyte used to support hydration and reduce irritation potential in formulas; it is considered low concern with no known pregnancy or breastfeeding risks in topical cosmetic use.

Sugar-derived humectant used to help bind water and improve skin feel. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.

Polyglycerin fatty-acid ester used as an emulsifier and solubilizer. Reviewed cosmetic safety references do not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.

Preservative booster and skin-conditioning agent. Considered safe for cosmetic use with low systemic exposure when used as intended.

Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.

Allantoin is a soothing skin protectant commonly used to help reduce irritation and support comfort, with no known pregnancy or breastfeeding concerns in topical cosmetic use.

A polyglycerin fatty-acid ester used as an emulsifier, dispersant or emollient. Cosmetic safety reviewers concluded that the assessed family of 274 polyglyceryl fatty acid esters is safe in current practices when formulated to be non-irritating. No pregnancy-specific concern was identified for normal topical cosmetic exposure.

Disodium EDTA is a chelating agent used to improve formula stability and performance; it is considered low concern in topical cosmetic use, with no known pregnancy or breastfeeding risks at typical concentrations.

Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.

Sodium hyaluronate (hyaluronic acid salt) is used for hydration and cushioning, with very low systemic absorption from topical use and no known pregnancy or breastfeeding concerns at cosmetic concentrations.

Orange peel essential oil used mainly for fragrance. Normal topical cosmetic use has no established pregnancy-specific concern. The practical concerns are oxidation, irritation, sensitisation and, depending on composition and processing, light-related skin reactions.

An exact label variant for lemon peel oil used mainly as a fragrance ingredient. At typical cosmetic concentrations there is no established pregnancy-specific concern. The main issues are oxidation, sensitisation and possible phototoxicity depending on composition, processing and use level.

Pomelo peel oil, used mainly for fragrance and skin conditioning. Citrus peel oils require formulation controls for irritation, sensitisation and phototoxic furocoumarins. No pregnancy-specific systemic hazard was identified for normal topical use of a compliant finished cosmetic.

Bergamot essential oil used mainly for fragrance. No pregnancy-specific hazard is established for normal topical cosmetic exposure. Expressed bergamot oil can be phototoxic unless furocoumarins are controlled, so sun-exposed use should follow the finished product directions and applicable fragrance standards.

A volatile oil from eucalyptus leaves used mainly for fragrance and skin conditioning. Cosmetic safety reviewers concluded that Eucalyptus globulus-derived ingredients are safe in current practices when formulated to be non-sensitising. Essential oils can irritate sensitive skin and should not be swallowed or used undiluted.

Lavender oil is used in cosmetics mainly as a fragrance ingredient. For normal diluted topical cosmetic use, current evidence does not establish a pregnancy-specific concern. This assessment does not cover ingestion, concentrated essential-oil use, or aromatherapy-style exposure. The more relevant practical issues in skincare are irritation or sensitisation in some users, so within this methodology it remains in no known risks.

A grape fruit or seed extract used for skin conditioning and antioxidant support. Cosmetic safety reviewers concluded that the assessed Vitis vinifera-derived ingredients are safe in current practices when formulated to be non-irritating and non-sensitising. Botanical sensitivity remains possible.

Citrus Aurantifolia (Lime) Fruit Extract is the extract of lime fruit and is distinct from neat lime peel essential oil. CIR concluded that citrus fruit-derived ingredients are safe in rinse-off and leave-on cosmetics when formulated to be non-irritating and non-sensitising, provided leave-on products contain no more than 0.0015% (15 ppm) 5-methoxypsoralen. No pregnancy-specific reproductive or developmental concern was identified for normal compliant cosmetic exposure.

A citrus fruit extract used mainly for skin conditioning. Cosmetic safety reviewers concluded that the assessed citrus fruit-derived ingredients are safe in current practices when formulated to be non-irritating and non-sensitising. Fruit extracts are distinct from concentrated peel essential oils, and botanical sensitivity remains possible.

An apple fruit extract used mainly for skin conditioning. Cosmetic safety reviewers concluded that Pyrus malus fruit extract and the other supported apple-derived ingredients are safe in current cosmetic practices of use and concentration. The conclusion does not extend to several separately identified root, stem, callus or oil ingredients for which evidence was insufficient. No pregnancy-specific concern was identified for normal topical use of the fruit extract.

A citrus fruit extract used mainly for skin conditioning. Cosmetic safety reviewers concluded that the assessed citrus fruit-derived ingredients are safe in current practices when formulated to be non-irritating and non-sensitising. Fruit extracts are distinct from concentrated peel essential oils, and botanical sensitivity remains possible.

Botanical skin-conditioning ingredient used in soothing and barrier-support formulas. Reviewed cosmetic safety sources support current cosmetic use when formulated to be non-sensitising, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

A botanical extract, juice or water used primarily for skin conditioning, moisturising, soothing or antioxidant support. Direct pregnancy studies of the named cosmetic material were not identified. No reproductive or developmental hazard was identified for normal topical exposure to a compliant finished cosmetic; oral herbal or medicinal use is outside this classification.

A hinoki-cypress leaf extract used for skin conditioning and fragrance. No pregnancy- or breastfeeding-specific hazard was identified for normal topical cosmetic exposure. Direct ingredient-specific pregnancy studies were not identified, so this assessment does not extend to oral supplements or medicinal use.

A processed bacterial ferment or lysate used for skin conditioning. It is not equivalent to applying an unspecified live culture. Available cosmetic-use information does not identify a pregnancy-specific concern for normal topical exposure.

A Chinese skullcap root extract used for skin conditioning and antioxidant effects. Cosmetic safety reviewers concluded that the root extract is safe in current practices of use and concentration; this conclusion does not extend to the generic whole-plant or sprout extracts, for which evidence was insufficient. No pregnancy-specific concern was identified for normal topical cosmetic exposure.

A purslane extract used mainly for skin conditioning. Cosmetic safety reviewers concluded that Portulaca oleracea extract is safe in current cosmetic practices when formulated to be non-sensitising. Botanical irritation or allergy remains possible, but no pregnancy-specific concern was identified for normal topical use.

An evening-primrose flower extract used for skin conditioning. No pregnancy- or breastfeeding-specific hazard was identified for normal topical cosmetic exposure. Direct ingredient-specific pregnancy studies were not identified, so this assessment does not extend to oral supplements or medicinal use.

A longleaf-pine leaf extract used for skin conditioning and fragrance. No pregnancy- or breastfeeding-specific hazard was identified for normal topical cosmetic exposure. Direct ingredient-specific pregnancy studies were not identified, so this assessment does not extend to oral supplements or medicinal use.

A Japanese elm root extract used as a skin-conditioning botanical. No pregnancy- or breastfeeding-specific hazard was identified for normal topical cosmetic exposure. Direct ingredient-specific pregnancy studies were not identified, so this assessment does not extend to oral supplements or medicinal use.

Kudzu root extract is a botanical skin-conditioning ingredient that may contain isoflavones including puerarin, daidzin and daidzein. Oral supplement exposure is not equivalent to the small amount used topically in a finished cosmetic. No evidence establishing a pregnancy or breastfeeding hazard from normal topical cosmetic use was identified.