PDRN Pink Collagen Capsule Cream

Niacinamide (vitamin B3) is widely used for barrier support and tone/texture benefits, and is generally considered safe in pregnancy and breastfeeding when used topically at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Solvent and humectant used to improve texture and ingredient delivery in topical cosmetic formulas. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.

Sources: CIR cosmetic ingredient safety references for alkane diols; EU CosIng / cosmetics regulatory inventory

Solvent and humectant used to improve texture and ingredient solubility. Low systemic exposure expected from topical cosmetic use.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.

Sources: CIR; EU/UK Cosmetics Regulation

Dipropylene glycol is used as a solvent and carrier in cosmetics; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Common emollient derived from fatty acids and glycerin. Used to soften skin and improve texture without pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

An ethoxylated glycerin humectant used to retain moisture and improve product texture. The Cosmetic Ingredient Review assessed glycerin ethoxylates including Glycereth-26 for current cosmetic use; available evidence does not identify a pregnancy- or breastfeeding-specific concern from normal topical exposure.

Sources: CIR: Safety Assessment of Glycerin Ethoxylates https://cir-safety.org/supplementaldoc/safety-assessment-glycerin-ethoxylates-used-cosmetics

Amino acid used as a humectant, skin-conditioning agent, and pH-adjusting support ingredient. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of α-Amino Acids as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Polymer thickener used to create gel textures. Large-molecule ingredient with negligible systemic absorption.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Fatty alcohol used as an emollient and thickener. Not the same as drying alcohols and not associated with pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Emollient ester/emulsifier used to improve skin feel and stabilise emulsions. Reviewed cosmetic safety sources support topical cosmetic use; the relevant practical caveat is formulation irritation potential rather than a pregnancy-specific concern.

Sources: CIR: Amended Safety Assessment of Alkyl Esters as Used in Cosmetics; CIR Quick Reference Table (Cetearyl Olivate); EU CosIng / cosmetics regulatory inventory

Lightweight emollient ester used to soften skin and improve glide. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Amended Safety Assessment of Alkyl Esters as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Olive-derived sorbitan ester used as an emulsifier and skin-conditioning ingredient. Reviewed cosmetic safety references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.

Sources: CIR: Safety Assessment of Sorbitan Esters as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Lightweight emollient used to support the skin barrier. Not associated with pregnancy-specific concerns at cosmetic exposure levels.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Polymer thickener used to stabilise emulsions. Large-molecule ingredient with low systemic absorption.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Preservative booster and skin-conditioning agent. Considered safe for cosmetic use with low systemic exposure when used as intended.

Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)

Skin-conditioning ingredient commonly used in leave-on skincare. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Adenosine Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Helianthus annuus (sunflower) seed oil is a common emollient rich in fatty acids and is generally well tolerated, with no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

A high-molecular-weight acrylic polymer used to thicken, stabilise or form a film. Dermal absorption of the intact polymer is expected to be limited. Cosmetic polymer assessments support normal topical use when residual monomers are appropriately controlled.

Sources: CIR: Safety Assessments of Acrylates Copolymers and Crosspolymers as Used in Cosmetics; European Commission CosIng ingredient inventory.

Disodium EDTA is a chelating agent used to improve formula stability and performance; it is considered low concern in topical cosmetic use, with no known pregnancy or breastfeeding risks at typical concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

A large, mostly insoluble polymer used as a binder, film former and texture ingredient. Cosmetic safety reviewers concluded that polyisobutene is safe in current cosmetic use; slow absorption and reproductive data on related polybutene do not indicate a pregnancy-specific concern from normal topical exposure.

Sources: CIR: Final Report on Polyisobutene and Hydrogenated Polyisobutene https://www.cir-safety.org/sites/default/files/polyene.pdf

Emulsifier and emollient used to stabilise creams and lotions. Not associated with pregnancy-specific concerns at cosmetic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

hydrolyzed sclerotium gum is a cosmetic formulation, mineral, sugar-derived or organic-acid ingredient. Available identity, use and related safety evidence did not identify a pregnancy-specific concern for normal topical cosmetic exposure. Cosmetic-grade purity and ordinary irritation precautions remain applicable.

Sources: CIR ingredient and related-family safety assessments; CIR Quick Reference Table https://www.cir-safety.org/supplementaldoc/quick-reference-table-december-2025; European Commission CosIng

A botanical extract, plant water or plant juice used for conditioning, soothing or antioxidant support. Direct pregnancy studies of this exact cosmetic material were not identified, but no reproductive or developmental hazard was identified for normal topical exposure. Oral herbal or medicinal use is outside this classification.

Sources: European Commission CosIng ingredient inventory; CIR botanical safety framework and relevant plant-derived ingredient assessments; no ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

No pregnancy-specific harm has been identified for ordinary, correctly formulated topical cosmetic use of alkanna tinctoria root extract. This is a bounded botanical/extract assessment; direct pregnancy studies of the exact material are limited and oral, medicinal, damaged-skin or aerosol exposure is not included.

Sources: https://www.cir-safety.org/sites/default/files/Botanical%20Decision%20Tree%20CIR%20June%202012%202.pdf

A rose flower distillate used for fragrance and skin conditioning. Cosmetic safety reviewers concluded that Rosa damascena-derived ingredients, including flower water, are safe in current practices when formulated to be non-irritating and non-sensitising. Natural fragrance allergens can still affect sensitive users.

Sources: CIR: Safety Assessment of Rosa damascena-Derived Ingredients as Used in Cosmetics https://www.cir-safety.org/sites/default/files/FR_RosaDamascena_032022.pdf

A botanical extract, juice or water used primarily for skin conditioning, moisturising, soothing or antioxidant support. Direct pregnancy studies of the named cosmetic material were not identified. No reproductive or developmental hazard was identified for normal topical exposure to a compliant finished cosmetic; oral herbal or medicinal use is outside this classification.

Sources: European Commission CosIng ingredient inventory; Cosmetic Ingredient Review botanical safety-assessment framework and relevant plant-family assessments. No ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

Nonionic surfactant and solubiliser used to disperse oils and fragrance. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Polysorbates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A botanical extract, juice or water used primarily for skin conditioning, moisturising, soothing or antioxidant support. Direct pregnancy studies of the named cosmetic material were not identified. No reproductive or developmental hazard was identified for normal topical exposure to a compliant finished cosmetic; oral herbal or medicinal use is outside this classification.

Sources: European Commission CosIng ingredient inventory; Cosmetic Ingredient Review botanical safety-assessment framework and relevant plant-family assessments. No ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

Emulsifier used to help oil and water phases remain mixed. Reviewed cosmetic safety sources support topical use in cosmetics; the main practical issue is irritation potential in some formulas rather than a pregnancy-specific concern.

Sources: CIR: Safety Assessment of Sorbitan Esters as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A botanical extract or plant water used for conditioning, soothing or antioxidant support. Direct pregnancy studies of this exact cosmetic material were not identified, but no reproductive or developmental hazard was identified for normal topical exposure. Oral herbal or medicinal use is outside this classification.

Sources: European Commission CosIng; CIR botanical safety framework and relevant plant-family assessments; no ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

An antioxidant peptide naturally present in the body and used in topical products for skin conditioning and tone. Clinical studies and systematic reviews report generally good tolerance of topical glutathione, although evidence for cosmetic benefits remains limited. No pregnancy-specific topical signal was identified.

Sources: PubMed: Systematic Review of the Efficacy and Safety of Topical Glutathione in Dermatology https://pubmed.ncbi.nlm.nih.gov/41416233/; PubMed: topical oxidized glutathione clinical trial https://pubmed.ncbi.nlm.nih.gov/25378941/

Sodium hyaluronate (hyaluronic acid salt) is used for hydration and cushioning, with very low systemic absorption from topical use and no known pregnancy or breastfeeding concerns at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Fatty alcohol emollient used to improve spreadability and reduce drag. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR ingredient status / report data sheet for Octyldodecanol; EU CosIng / cosmetics regulatory inventory

Salmon-egg extract contains nutrient proteins and lipids, with adult testing supporting tolerability of diluted skin formulations. Fish allergy remains relevant, and injectable DNA or peptide preparations are not covered. Ordinary diluted use on intact external skin is expected to produce low systemic exposure, with no identified pregnancy-specific concern for that preparation. This exposure-based conclusion does not mean pregnancy safety has been proven.

Sources: https://pubmed.ncbi.nlm.nih.gov/23738607/

Cationic hyaluronate derivative used as a humectant and conditioning ingredient. Reviewed topical hyaluronate safety sources support cosmetic use, with no pregnancy- or breastfeeding-specific concern identified.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Vitamin E antioxidant used to protect oils and support the skin barrier. Not associated with pregnancy-specific concerns at cosmetic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Hydrogenated emulsifier used to support skin barrier feel. Not associated with pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US)

Skin-identical barrier lipid used to support the stratum corneum and reduce dryness. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Ceramides as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A vitamin B ingredient or derivative used for skin or hair conditioning. These vitamins are normal nutrients and no pregnancy-specific concern was identified for the small topical exposure expected from a finished cosmetic. This assessment does not replace guidance about oral supplements or therapeutic doses.

Sources: NIH Office of Dietary Supplements vitamin fact sheets https://ods.od.nih.gov/factsheets/list-all/; CIR: Panthenol, Pantothenic Acid and Derivatives safety assessment https://www.cir-safety.org/supplementaldoc/safety-assessment-panthenol-pantothenic-acid-and-derivatives-used-cosmetics-1

Thioctic acid is another name for alpha-lipoic acid, an antioxidant used in topical skincare. No pregnancy-specific contraindication or reproductive hazard was identified for normal topical cosmetic exposure.

Sources: PubChem: alpha-lipoic acid/thioctic acid substance identity; European Commission CosIng ingredient inventory; published clinical literature on alpha-lipoic acid. No ingredient-specific pregnancy study of topical cosmetic use was identified.

Modified hyaluronate humectant and skin-conditioning ingredient. Reviewed cosmetic safety sources support topical hyaluronate ingredients, with no pregnancy- or breastfeeding-specific concern identified for normal cosmetic use.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Hydrolyzed collagen extract is a processed protein preparation used for skin conditioning. CIR lists it as safe in current cosmetic use; source quality, microbial controls and possible protein allergy remain relevant, but no topical pregnancy-specific hazard was identified. Direct human pregnancy studies of this exact ingredient were not identified; the rating applies to normal topical cosmetic use.

Sources: https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Humectant and skin-conditioning ingredient in the hyaluronate family. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Synthetic peptide used as a skin-conditioning ingredient. Reviewed cosmetic safety sources do not indicate a known pregnancy- or breastfeeding-specific concern in normal topical cosmetic use. The available cosmetic safety assessment concluded this ingredient is safe in cosmetics at concentrations up to 0.005%; safety above that concentration was not established in the reviewed report.

Sources: CIR Expert Panel, Safety Assessment of Acetyl Hexapeptide-8 Amide as Used in Cosmetics, final report, 2021

Copper-binding carrier peptide also known as GHK-Cu, used topically in cosmetic skin-renewal, anti-aging, barrier-support and hair/scalp products. Reviewed literature describes topical cosmetic use and does not identify a pregnancy- or breastfeeding-specific risk signal for normal topical use. This assessment does not apply to injectable copper peptides or oral peptide/copper supplementation.

Sources: Schagen SK. Topical Peptide Treatments with Effective Anti-Aging Results. Cosmetics. 2017;4(2):16. doi:10.3390/cosmetics4020016; Pickart L et al. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018;19(7):1987. doi:10.3390/ijms19071987.

Humectant and preservative booster used to support product stability. Low systemic exposure expected from topical cosmetic use.

Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)

High-water-binding humectant used to support hydration at the skin surface. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Synthetic palmitoylated signal peptide used in topical anti-aging cosmetics. It is one of the better-studied cosmetic peptides, with reviewed topical literature describing controlled cosmetic studies and no pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.

Sources: Schagen SK. Topical Peptide Treatments with Effective Anti-Aging Results. Cosmetics. 2017;4(2):16. doi:10.3390/cosmetics4020016; Robinson LR et al. Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin. Int J Cosmet Sci. 2005;27(3):155-160.

Synthetic palmitoylated peptide used in topical cosmetic anti-aging and skin-conditioning formulas. Reviewed topical peptide literature lists palmitoyl hexapeptide-12 among topically used matricin-style peptides and does not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.

Sources: Schagen SK. Topical Peptide Treatments with Effective Anti-Aging Results. Cosmetics. 2017;4(2):16. doi:10.3390/cosmetics4020016; CIR Expert Panel safety assessment of tripeptide-1, hexapeptide-12 and related derivatives.

Crosslinked hyaluronate humectant used to support hydration at the skin surface. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Humectant and skin-conditioning ingredient in the hyaluronate family. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Potassium hyaluronate is a salt of hyaluronic acid used as a surface humectant and skin conditioner. The Cosmetic Ingredient Review concluded that reviewed hyaluronates are safe in current cosmetic use, with no pregnancy- or breastfeeding-specific concern identified for normal topical exposure.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics https://www.cir-safety.org/supplementaldoc/safety-assessment-hyaluronates-used-cosmetics