Niacinamide 10% + TXA 4% Serum

Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

Niacinamide (vitamin B3) is widely used for barrier support and tone/texture benefits, and is generally considered safe in pregnancy and breastfeeding when used topically at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

A cosmetic ester or glyceride used mainly for emollience, texture, dispersion or emulsification. The relevant fatty-acid, glyceryl, sorbitan, polyglyceryl and related ester safety assessments support use in current cosmetic practices. No pregnancy-specific hazard signal was identified for normal topical exposure; local irritation remains formulation-dependent.

Sources: CIR safety assessments of Fatty Acid Esters, Glyceryl Esters, Sorbitan Fatty Acid Esters, Polyglyceryl Fatty Acid Esters and Monoalkylglycol Dialkyl Acid Esters; CIR December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf; European Commission CosIng ingredient inventory.

1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.

Sources: CIR; EU/UK Cosmetics Regulation

Sodium hyaluronate (hyaluronic acid salt) is used for hydration and cushioning, with very low systemic absorption from topical use and no known pregnancy or breastfeeding concerns at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

An ivy-gourd fruit extract used for skin conditioning and antioxidant support. No pregnancy- or breastfeeding-specific hazard was identified for normal topical cosmetic exposure. Direct ingredient-specific pregnancy studies were not identified, so this assessment does not extend to oral supplements or medicinal use.

Sources: European Commission CosIng ingredient inventory; Cosmetic Ingredient Review botanical safety-assessment framework and relevant ingredient-family assessments. No ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

A plant-part extract used for skin conditioning, soothing, fragrance or antioxidant support. No pregnancy-specific systemic signal was identified for normal topical cosmetic exposure. This assessment does not extend to essential oils, oral herbal products or medicinal doses, and botanical sensitivity remains possible.

Sources: European Commission CosIng ingredient inventory; CIR botanical safety framework and relevant plant-derived ingredient assessments; peer-reviewed cosmetic-use literature.

A plant-derived fatty oil or butter used mainly as an emollient, conditioning ingredient or texture agent. Cosmetic safety reviewers concluded that the assessed plant-derived fatty acid oils are safe in current practices of use and concentration. This conclusion applies to cosmetic-grade fixed oils rather than similarly named volatile essential oils. Seed or food allergy may still matter for a susceptible person.

Sources: CIR: Safety Assessment of Plant-Derived Fatty Acid Oils as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=ad62ac6b-8e74-ec11-8943-0022482f06a6

Olive-derived emollient oil used for skin conditioning and barrier feel. Normal topical cosmetic use has no known pregnancy- or breastfeeding-specific concern identified in reviewed cosmetic references.

Sources: CIR: Safety Assessment of Plant-Derived Fatty Acid Oils as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Plant-derived emollient oil used to soften skin and improve formula feel. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

Sources: CIR: Final Report on the Safety Assessment of Simmondsia Chinensis (Jojoba) Seed Oil and related jojoba-derived ingredients; EU CosIng / cosmetics regulatory inventory

Grape seed-derived emollient oil used for skin conditioning. Normal topical cosmetic use has no known pregnancy- or breastfeeding-specific concern identified in reviewed cosmetic references.

Sources: CIR: Safety Assessment of Plant-Derived Fatty Acid Oils as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A fruit, seed or food-plant extract used for skin conditioning and antioxidant support. No pregnancy-specific signal was identified for the low topical exposure expected from a finished cosmetic. Direct pregnancy studies are generally unavailable, and botanical allergy remains possible.

Sources: European Commission CosIng ingredient inventory; CIR botanical safety framework and relevant fruit-derived ingredient assessments; peer-reviewed cosmetic and phytochemical literature for the named plants.

Humectant and skin-conditioning ingredient in the hyaluronate family. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A hinoki-cypress leaf extract used for skin conditioning and fragrance. No pregnancy- or breastfeeding-specific hazard was identified for normal topical cosmetic exposure. Direct ingredient-specific pregnancy studies were not identified, so this assessment does not extend to oral supplements or medicinal use.

Sources: European Commission CosIng ingredient inventory; Cosmetic Ingredient Review botanical safety-assessment framework and relevant ingredient-family assessments. No ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

prunus persica flower extract is a botanical-derived cosmetic conditioning ingredient. The reviewed identity is not a concentrated essential oil or an oral herbal preparation. Available cosmetic evidence and expected topical exposure did not identify a pregnancy-specific contraindication, although botanical irritation or allergy remains possible.

Sources: CIR ingredient-specific and botanical-family safety assessments; CIR Quick Reference Table https://www.cir-safety.org/supplementaldoc/quick-reference-table-december-2025; European Commission CosIng

A plant-derived oil or hydrogenated wax used mainly as an emollient and skin-conditioning ingredient. Cosmetic safety reviewers concluded that these named sea buckthorn, tea seed, jojoba and grape seed ingredients are safe in current practices of use and concentration. Plant allergy remains possible.

Sources: CIR: Hippophae Rhamnoides Oil, Camellia Sinensis Seed Oil, Hydrogenated Jojoba Oil and Vitis Vinifera (Grape) Seed Oil conclusions; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

yeast ferment extract is a fermentation-, microbial- or algae-derived cosmetic conditioning material. The assessment applies to the defined cosmetic ingredient rather than live organisms or oral supplements. No pregnancy-specific concern was identified for normal topical use; formulation purity and sensitivity remain relevant.

Sources: CIR assessments of microbial polysaccharides, fermentation-derived and algae-derived cosmetic ingredients; CIR Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Botanical skin-conditioning ingredient used in soothing and barrier-support formulas. Reviewed cosmetic safety sources support current cosmetic use when formulated to be non-sensitising, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

Sources: CIR: Safety Assessment of Centella asiatica-derived Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A botanical extract, juice or water used primarily for skin conditioning, moisturising, soothing or antioxidant support. Direct pregnancy studies of the named cosmetic material were not identified. No reproductive or developmental hazard was identified for normal topical exposure to a compliant finished cosmetic; oral herbal or medicinal use is outside this classification.

Sources: European Commission CosIng ingredient inventory; Cosmetic Ingredient Review botanical safety-assessment framework and relevant plant-family assessments. No ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

A processed cosmetic ferment, extract or fermentation-derived material used for conditioning, moisturising or formula support. It is not equivalent to applying an unspecified live culture. Available cosmetic safety assessments do not identify a pregnancy- or breastfeeding-specific hazard for normal topical use, assuming appropriate identity, preservation and microbial-quality controls.

Sources: CIR safety assessments and strategy documents for Yeast-Derived Ingredients, Lactobacillus Ferment Ingredients and cosmetic microbial fermentation products; European Commission CosIng ingredient inventory.

High-water-binding humectant used to support hydration at the skin surface. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Humectant and preservative booster. Considered safe for cosmetic use with low systemic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

A sugar-derived ester used as an emulsifier, surfactant or skin-conditioning ingredient. Cosmetic safety reviewers concluded that sucrose palmitate and sucrose tetrastearate triacetate are safe in current practices of use and concentration.

Sources: CIR: Sucrose fatty acid esters conclusions, IJT 40(Suppl. 2), 2021; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Hydrogenated emulsifier used to support skin barrier feel. Not associated with pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US)

A high-molecular-weight carbohydrate gum produced by microbial fermentation and used for hydration, texture or film formation. Cosmetic safety reviewers concluded that the assessed microbial polysaccharide gums are safe in current practices of use and concentration. Dermal absorption of the intact polymers is expected to be limited.

Sources: CIR: Safety Assessment of Microbial Polysaccharide Gums as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=c052d083-8e74-ec11-8943-0022482f06a6

Chelating agent used to improve formula stability. Used at low levels and not associated with pregnancy-specific concerns.

Sources: European cosmetics regulatory framework

This cellulose or modified-cellulose polymer is used as a thickener, film former or stabilizer. Cosmetic Ingredient Review data indicate that cellulose polymers do not appreciably penetrate skin and are safe in current cosmetic use, with at most minimal irritation reported.

Sources: CIR: Amended Safety Assessment of Cellulose and Related Polymers as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=2e65c18f-8c74-ec11-8943-0022482f06a6

Common emollient derived from fatty acids and glycerin. Used to soften skin and improve texture without pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Panthenol (pro-vitamin B5) is used for soothing and barrier support and is generally well tolerated, with no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

A vitamin B ingredient or derivative used for skin or hair conditioning. These vitamins are normal nutrients and no pregnancy-specific concern was identified for the small topical exposure expected from a finished cosmetic. This assessment does not replace guidance about oral supplements or therapeutic doses.

Sources: NIH Office of Dietary Supplements vitamin fact sheets https://ods.od.nih.gov/factsheets/list-all/; CIR: Panthenol, Pantothenic Acid and Derivatives safety assessment https://www.cir-safety.org/supplementaldoc/safety-assessment-panthenol-pantothenic-acid-and-derivatives-used-cosmetics-1

A high-molecular-weight glutamic-acid polymer used as a humectant and film former. Absorption of the intact polymer through skin is expected to be limited, and no pregnancy-specific concern was identified for normal topical cosmetic use. This is distinct from medicinal injectable or drug-delivery forms.

Sources: Peer-reviewed literature on poly-gamma-glutamic acid biomaterials and topical hydration; European Commission CosIng ingredient inventory.

A stable ether derivative of vitamin C used as an antioxidant and brightening ingredient. Pregnancy-specific topical studies are limited, but no pregnancy-specific contraindication was identified in the reviewed literature. Published case reports describe allergic contact dermatitis, so local sensitivity remains possible and this classification should not be read as proof that irritation cannot occur.

Sources: CIR: Safety Assessment of Ethers of Ascorbic Acid https://www.cir-safety.org/sites/default/files/ethers_of_ascorbate.pdf; PubMed: 3-O-ethyl-L-ascorbic acid topical delivery https://pubmed.ncbi.nlm.nih.gov/31517290/; PubMed: allergic contact dermatitis case report https://pubmed.ncbi.nlm.nih.gov/24846587/

Skin-identical barrier lipid used to support the stratum corneum and reduce dryness. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Ceramides as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Starch-derived polysaccharide used as a binder, film former and texture support ingredient. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.

Sources: CIR cosmetic ingredient safety references for polysaccharides/starch-derived ingredients; EU CosIng / cosmetics regulatory inventory

A triterpene glycoside associated with Centella asiatica and used in soothing and skin-conditioning formulas. Pregnancy-specific evidence for isolated topical asiaticoside is limited. Cosmetic safety reviewers considered Centella-derived ingredients acceptable at current cosmetic exposure but noted that asiaticoside and related triterpenes may contribute to sensitisation. No pregnancy-specific topical contraindication was identified in the reviewed material.

Sources: CIR: Safety Assessment of Centella asiatica-Derived Ingredients as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-centella-asiatica-derived-ingredients-used-cosmetics-1

A triterpene associated with Centella asiatica and used in soothing and skin-conditioning formulas. Pregnancy-specific evidence for isolated topical madecassic acid is limited. Evidence for the related Centella ingredient family supports current cosmetic exposure when products are formulated to avoid sensitisation; no pregnancy-specific topical contraindication was identified in the reviewed material.

Sources: CIR: Safety Assessment of Centella asiatica-Derived Ingredients as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-centella-asiatica-derived-ingredients-used-cosmetics-1

A triterpene associated with Centella asiatica and used in skin-conditioning formulas. Pregnancy-specific evidence for isolated topical asiatic acid is limited. Cosmetic safety reviewers considered Centella-derived ingredients acceptable at current cosmetic exposure but identified asiatic acid and related constituents as potential contributors to sensitisation. No pregnancy-specific topical contraindication was identified in the reviewed material.

Sources: CIR: Safety Assessment of Centella asiatica-Derived Ingredients as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-centella-asiatica-derived-ingredients-used-cosmetics-1

A hyaluronate-derived conditioning and humectant material modified with a dimethylsilanol group. CIR concluded that reviewed hyaluronates are safe in current cosmetic practices and noted their large molecular size and low expected skin absorption. The exact silanol derivatives have less direct pregnancy-specific evidence, but no reproductive hazard signal was identified for normal topical cosmetic exposure.

Sources: CIR: Safety Assessment of Hyaluronates https://www.cir-safety.org/sites/default/files/TR_Hyaluronates_032023_1.pdf; European Commission CosIng ingredient inventory for Dimethylsilanol Hyaluronate and Sodium Hyaluronate Dimethylsilanol.

Humectant and skin-conditioning ingredient in the hyaluronate family. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Potassium hyaluronate is a salt of hyaluronic acid used as a surface humectant and skin conditioner. The Cosmetic Ingredient Review concluded that reviewed hyaluronates are safe in current cosmetic use, with no pregnancy- or breastfeeding-specific concern identified for normal topical exposure.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics https://www.cir-safety.org/supplementaldoc/safety-assessment-hyaluronates-used-cosmetics

Cationic hyaluronate derivative used as a humectant and conditioning ingredient. Reviewed topical hyaluronate safety sources support cosmetic use, with no pregnancy- or breastfeeding-specific concern identified.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Crosslinked hyaluronate humectant used to support hydration at the skin surface. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A hyaluronate-derived conditioning and humectant material modified with a dimethylsilanol group. CIR concluded that reviewed hyaluronates are safe in current cosmetic practices and noted their large molecular size and low expected skin absorption. The exact silanol derivatives have less direct pregnancy-specific evidence, but no reproductive hazard signal was identified for normal topical cosmetic exposure.

Sources: CIR: Safety Assessment of Hyaluronates https://www.cir-safety.org/sites/default/files/TR_Hyaluronates_032023_1.pdf; European Commission CosIng ingredient inventory for Dimethylsilanol Hyaluronate and Sodium Hyaluronate Dimethylsilanol.

Modified hyaluronate humectant and skin-conditioning ingredient. Reviewed cosmetic safety sources support topical hyaluronate ingredients, with no pregnancy- or breastfeeding-specific concern identified for normal cosmetic use.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Natural polysaccharide thickener used for stability and texture. Not associated with pregnancy-specific concerns.

Sources: European cosmetics regulatory framework