PDRN Hyaluronic Acid 100 Moisturizing Cream

Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

Niacinamide (vitamin B3) is widely used for barrier support and tone/texture benefits, and is generally considered safe in pregnancy and breastfeeding when used topically at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Humectant and preservative booster. Considered safe for cosmetic use with low systemic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.

Sources: CIR; EU/UK Cosmetics Regulation

Protein-derived skin- and hair-conditioning ingredient used to support feel and hydration at the surface. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.

Sources: CIR cosmetic ingredient safety references for protein hydrolysates; EU CosIng / cosmetics regulatory inventory

Sodium hyaluronate (hyaluronic acid salt) is used for hydration and cushioning, with very low systemic absorption from topical use and no known pregnancy or breastfeeding concerns at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Neem leaf extract is used topically for skin conditioning and antimicrobial support. Reproductive concerns reported for concentrated neem seed preparations, intrauterine exposure, or high oral doses do not establish a hazard from normal topical cosmetic exposure to a leaf extract.

Sources: PubMed: oral purified neem seed extracts in primates https://pubmed.ncbi.nlm.nih.gov/8773426/; PubMed: intrauterine neem oil in primates https://pubmed.ncbi.nlm.nih.gov/8143455/; European Commission CosIng ingredient inventory. No human pregnancy study of normal topical cosmetic leaf-extract use was identified.

Humectant and skin-conditioning ingredient in the hyaluronate family. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Neem flower extract is used as a botanical skin-conditioning ingredient. A high-dose oral rat study altered the oestrous cycle and ovulation but did not show anti-implantation, abortifacient, or teratogenic effects. That oral dose does not establish a hazard from normal topical cosmetic exposure.

Sources: PubMed: high-dose oral neem flower extract reproductive study in rats https://pubmed.ncbi.nlm.nih.gov/19357745/; European Commission CosIng ingredient inventory. No human pregnancy study of normal topical cosmetic use was identified.

An ivy-gourd fruit extract used for skin conditioning and antioxidant support. No pregnancy- or breastfeeding-specific hazard was identified for normal topical cosmetic exposure. Direct ingredient-specific pregnancy studies were not identified, so this assessment does not extend to oral supplements or medicinal use.

Sources: European Commission CosIng ingredient inventory; Cosmetic Ingredient Review botanical safety-assessment framework and relevant ingredient-family assessments. No ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

High-water-binding humectant used to support hydration at the skin surface. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

An aloe flower extract used for skin conditioning. Cosmetic safety reviewers concluded that supported Aloe barbadensis-derived ingredients are safe in current practices, with anthraquinone impurities controlled to no more than 50 ppm. No pregnancy-specific concern was identified for normal topical cosmetic exposure.

Sources: CIR: December 2025 Quick Reference Table, Aloe Barbadensis Flower Extract conclusion https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

A fruit, seed or food-plant extract used for skin conditioning and antioxidant support. No pregnancy-specific signal was identified for the low topical exposure expected from a finished cosmetic. Direct pregnancy studies are generally unavailable, and botanical allergy remains possible.

Sources: European Commission CosIng ingredient inventory; CIR botanical safety framework and relevant fruit-derived ingredient assessments; peer-reviewed cosmetic and phytochemical literature for the named plants.

Holy basil leaf extract is used for antioxidant and skin-conditioning purposes. Available warnings and pharmacology largely concern oral herbal use. No pregnancy-specific systemic hazard was identified for normal topical exposure to a compliant cosmetic, although botanical sensitivity remains possible.

Sources: PubMed: oral toxicological evaluation of Ocimum sanctum leaf extract https://pubmed.ncbi.nlm.nih.gov/24616736/; European Commission CosIng ingredient inventory. No human pregnancy study of topical cosmetic use was identified.

A red-algae-derived extract used for skin conditioning, hydration or formula texture. Cosmetic safety reviewers concluded that the assessed red algae ingredients, including this extract, are safe in current practices of use and concentration. Cosmetic manufacturers should control naturally occurring contaminants such as heavy metals and arsenic.

Sources: CIR: Safety Assessment of Red Algae-Derived Ingredients as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=cef5b6e9-8c74-ec11-8943-0022482f06a6

Turmeric root extract is used for antioxidant and skin-conditioning effects. Pregnancy cautions relate mainly to concentrated oral supplements; normal topical cosmetic exposure is substantially smaller. The principal topical concern is irritation or allergy in sensitive users.

Sources: NIH NCCIH: Turmeric safety, including separate oral-supplement and topical cautions https://www.nccih.nih.gov/health/turmeric; European Commission CosIng ingredient inventory.

A leaf extract used in soothing and skin-conditioning formulas. Cosmetic safety reviewers concluded that Centella asiatica leaf extract is safe at current cosmetic exposure when products are formulated to be non-sensitising. The assessment considered systemic and reproductive findings reported at substantially higher oral exposures; these did not establish a pregnancy-specific concern for ordinary topical cosmetic use. Centella constituents can still cause contact sensitivity in some people.

Sources: CIR: Safety Assessment of Centella asiatica-Derived Ingredients as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-centella-asiatica-derived-ingredients-used-cosmetics-1

Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Solvent and humectant used to improve texture and ingredient solubility. Low systemic exposure expected from topical cosmetic use.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Polymer thickener used to stabilise emulsions. Large-molecule ingredient with low systemic absorption.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

A glycerin dimer used to attract moisture and improve skin feel. Cosmetic safety reviewers assessed diglycerin with related polyglycerins and concluded that they are safe in current practices of use and concentration. No pregnancy-specific concern was identified for normal topical cosmetic exposure.

Sources: CIR: Safety Assessment of Diglycerin and Polyglycerins as Used in Cosmetics https://www.cir-safety.org/panelbook/safety-assessment-diglycerin-and-polyglycerin-3-6-and-10-used-cosmetics

Large polymer thickener, stabilizer and texture ingredient used in gels, creams and sunscreens. Systemic exposure from topical cosmetic use is expected to be low, with no pregnancy- or breastfeeding-specific concern identified in reviewed cosmetic references.

Sources: CIR cosmetic ingredient safety references for acrylates copolymers; EU CosIng / cosmetics regulatory inventory

Polymer thickener and stabiliser used in creams and sunscreens. Low systemic exposure expected.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

A sugar-derived surfactant and emulsifier. Cosmetic safety reviewers concluded that alkyl glucosides, including C12-20 alkyl glucoside, are safe in current practices when formulated to be non-irritating.

Sources: CIR: Alkyl Glucosides conclusion, IJT 32(Suppl. 3), 2013; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Solvent and humectant used to improve texture and ingredient delivery in topical cosmetic formulas. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.

Sources: CIR cosmetic ingredient safety references for alkane diols; EU CosIng / cosmetics regulatory inventory

Preservative booster and skin-conditioning agent. Considered safe for cosmetic use with low systemic exposure when used as intended.

Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)

Skin-conditioning ingredient commonly used in leave-on skincare. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Adenosine Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Chelating agent used to improve formula stability. Used at low levels and not associated with pregnancy-specific concerns.

Sources: European cosmetics regulatory framework

An amino alcohol used to adjust pH and support formula stability. The finished product pH, rather than reproductive toxicity, is the relevant safety consideration. No pregnancy-specific systemic concern was identified for normal topical cosmetic exposure.

Sources: CIR safety assessments of amino alcohols and pH-adjusting cosmetic ingredients; European Commission CosIng ingredient inventory.

A high-molecular-weight film-forming copolymer used in hair, oral-care and skin products. Cosmetic safety reviewers concluded that PVM/MA copolymer is safe in current practices of use and concentration. Absorption of the intact polymer is expected to be limited.

Sources: CIR: Safety Assessment of PVM/MA Copolymer and Its Esters, IJT 30(Suppl. 2), 2011; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

A triterpene glycoside associated with Centella asiatica and used in soothing and skin-conditioning formulas. Pregnancy-specific evidence for isolated topical madecassoside is limited. Cosmetic safety reviewers considered Centella-derived ingredients acceptable at current cosmetic exposure but noted that madecassoside and related triterpenes may contribute to sensitisation, so products should be formulated to avoid sensitising concentrations. No pregnancy-specific topical contraindication was identified in the reviewed material.

Sources: CIR: Safety Assessment of Centella asiatica-Derived Ingredients as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-centella-asiatica-derived-ingredients-used-cosmetics-1

c12-13 alketh-9 is a cosmetic surfactant, emulsifier or conditioning agent. Relevant CIR family assessments support use when formulated to be non-irritating and with appropriate impurity controls. Local skin or eye irritation is possible, but no pregnancy-specific concern was identified for normal topical or rinse-off use.

Sources: CIR Safety Assessment of Alkyl PEG/PPG Ethers as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-alkyl-peg/ppg-ethers-used-cosmetics; CIR ingredient-family conclusions.

A hyaluronate-derived conditioning and humectant material modified with a dimethylsilanol group. CIR concluded that reviewed hyaluronates are safe in current cosmetic practices and noted their large molecular size and low expected skin absorption. The exact silanol derivatives have less direct pregnancy-specific evidence, but no reproductive hazard signal was identified for normal topical cosmetic exposure.

Sources: CIR: Safety Assessment of Hyaluronates https://www.cir-safety.org/sites/default/files/TR_Hyaluronates_032023_1.pdf; European Commission CosIng ingredient inventory for Dimethylsilanol Hyaluronate and Sodium Hyaluronate Dimethylsilanol.

Humectant and skin-conditioning ingredient in the hyaluronate family. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A triterpene glycoside associated with Centella asiatica and used in soothing and skin-conditioning formulas. Pregnancy-specific evidence for isolated topical asiaticoside is limited. Cosmetic safety reviewers considered Centella-derived ingredients acceptable at current cosmetic exposure but noted that asiaticoside and related triterpenes may contribute to sensitisation. No pregnancy-specific topical contraindication was identified in the reviewed material.

Sources: CIR: Safety Assessment of Centella asiatica-Derived Ingredients as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-centella-asiatica-derived-ingredients-used-cosmetics-1

Potassium hyaluronate is a salt of hyaluronic acid used as a surface humectant and skin conditioner. The Cosmetic Ingredient Review concluded that reviewed hyaluronates are safe in current cosmetic use, with no pregnancy- or breastfeeding-specific concern identified for normal topical exposure.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics https://www.cir-safety.org/supplementaldoc/safety-assessment-hyaluronates-used-cosmetics

Cationic hyaluronate derivative used as a humectant and conditioning ingredient. Reviewed topical hyaluronate safety sources support cosmetic use, with no pregnancy- or breastfeeding-specific concern identified.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Crosslinked hyaluronate humectant used to support hydration at the skin surface. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A hyaluronate-derived conditioning and humectant material modified with a dimethylsilanol group. CIR concluded that reviewed hyaluronates are safe in current cosmetic practices and noted their large molecular size and low expected skin absorption. The exact silanol derivatives have less direct pregnancy-specific evidence, but no reproductive hazard signal was identified for normal topical cosmetic exposure.

Sources: CIR: Safety Assessment of Hyaluronates https://www.cir-safety.org/sites/default/files/TR_Hyaluronates_032023_1.pdf; European Commission CosIng ingredient inventory for Dimethylsilanol Hyaluronate and Sodium Hyaluronate Dimethylsilanol.

Modified hyaluronate humectant and skin-conditioning ingredient. Reviewed cosmetic safety sources support topical hyaluronate ingredients, with no pregnancy- or breastfeeding-specific concern identified for normal cosmetic use.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Long-chain fatty alcohol used as an emollient and thickener. This is not the same concern profile as simple drying alcohols; reviewed cosmetic safety sources support normal topical use.

Sources: CIR: Final Report on the Safety Assessment of Cetearyl Alcohol, Cetyl Alcohol, Isostearyl Alcohol, Myristyl Alcohol, and Behenyl Alcohol; EU CosIng / cosmetics regulatory inventory

A long-chain fatty alcohol or fatty-alcohol blend used as an emollient, emulsifier or thickener. Cosmetic safety assessments of long-chain fatty alcohols support use in current cosmetic practices; systemic absorption and reproductive exposure from normal topical use are expected to be low.

Sources: CIR: Safety Assessment of Fatty Alcohols as Used in Cosmetics; CIR December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Polymer thickener used to create gel textures. Large-molecule ingredient with negligible systemic absorption.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)