PDRN Hyaluronic Acid Hydrating Capsule Mist

1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.

Sources: CIR; EU/UK Cosmetics Regulation

An acetylated amino-acid derivative used for skin conditioning. CIR included Acetyl Glutamine in its safe-as-used conclusion for amino-acid alkyl amides when products are formulated to be non-irritating. No pregnancy-specific concern was identified for normal topical cosmetic exposure.

Sources: CIR: Safety Assessment of Amino Acid Alkyl Amides as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=f8a7b89b-8e74-ec11-8943-0022482f06a6

Skin-conditioning ingredient commonly used in leave-on skincare. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Adenosine Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A plant-derived polysaccharide used to thicken and stabilise formulas. Cosmetic safety reviewers concluded that agar is safe in current practices. Loose powder should not be deliberately inhaled.

Sources: CIR: Plant Polysaccharide Gums final assessment, September 2015; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Allantoin is a soothing skin protectant commonly used to help reduce irritation and support comfort, with no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

An aloe flower extract used for skin conditioning. Cosmetic safety reviewers concluded that supported Aloe barbadensis-derived ingredients are safe in current practices, with anthraquinone impurities controlled to no more than 50 ppm. No pregnancy-specific concern was identified for normal topical cosmetic exposure.

Sources: CIR: December 2025 Quick Reference Table, Aloe Barbadensis Flower Extract conclusion https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

A botanical extract, juice or water used primarily for skin conditioning, moisturising, soothing or antioxidant support. Direct pregnancy studies of the named cosmetic material were not identified. No reproductive or developmental hazard was identified for normal topical exposure to a compliant finished cosmetic; oral herbal or medicinal use is outside this classification.

Sources: European Commission CosIng ingredient inventory; Cosmetic Ingredient Review botanical safety-assessment framework and relevant plant-family assessments. No ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

A mineral-derived colourant, absorbent or texture ingredient. Purity and avoiding respirable exposure from loose powders or sprays are the practical formulation considerations. Dermal absorption is expected to be limited, and no reproductive or developmental hazard was identified for normal non-inhaled topical cosmetic use.

Sources: European Commission CosIng ingredient inventory and cosmetic purity requirements; CIR safety assessments of mineral-derived ingredients, silicates and cosmetic colourants.

Sugar-derived humectant used to support hydration, often as part of saccharide blends. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Saccharide Humectants / Saccharide Isomerate, etc.; EU CosIng / cosmetics regulatory inventory

aureobasidium pullulans ferment is a fermentation-derived or microbial lysate cosmetic conditioning material. The assessment applies to the defined non-live cosmetic ingredient rather than live organisms or oral supplements. No pregnancy-specific concern was identified for normal topical use; formulation purity and sensitivity remain relevant.

Sources: CIR assessments of microbial polysaccharides, fermentation-derived and lysate cosmetic ingredients; CIR Quick Reference Table https://www.cir-safety.org/supplementaldoc/quick-reference-table-december-2025

A colour additive used in cosmetics. FDA lists caramel and beta-carotene as permitted cosmetic colour additives, including for eye-area and general cosmetic use, subject to applicable identity, purity and manufacturing requirements. No pregnancy-specific concern was identified from normal topical cosmetic exposure.

Sources: FDA: Color Additives Permitted for Use in Cosmetics https://www.fda.gov/cosmetics/cosmetic-ingredient-names/color-additives-permitted-use-cosmetics; 21 CFR Part 73.

Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

A common inorganic electrolyte used to control viscosity, stabilise a formula or condition skin. At cosmetic concentrations these salts do not present a pregnancy-specific concern; concentrated formulas can still sting damaged or very sensitive skin.

Sources: European Commission CosIng ingredient inventory; PubChem compound records for potassium chloride, magnesium chloride and calcium chloride; established pharmaceutical and food use of these electrolytes.

A processed cosmetic ferment, extract or fermentation-derived material used for conditioning, moisturising or formula support. It is not equivalent to applying an unspecified live culture. Available cosmetic safety assessments do not identify a pregnancy- or breastfeeding-specific hazard for normal topical use, assuming appropriate identity, preservation and microbial-quality controls.

Sources: CIR safety assessments and strategy documents for Yeast-Derived Ingredients, Lactobacillus Ferment Ingredients and cosmetic microbial fermentation products; European Commission CosIng ingredient inventory.

Common emollient derived from fatty acids and glycerin. Used to soften skin and improve texture without pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Humectant and preservative booster used to support product stability. Low systemic exposure expected from topical cosmetic use.

Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)

For ordinary, correctly formulated topical cosmetic use, no pregnancy-specific harm has been identified for castanea sativa seed extract. Chestnut seed extract is food-derived but differs from shell extract; nut allergy is possible. Direct pregnancy studies of this exact material are limited; this assessment does not cover ingestion, medicinal-strength use, damaged skin, or aerosol exposure.

Sources: https://www.cir-safety.org/sites/default/files/Botanical%20Decision%20Tree%20CIR%20June%202012%202.pdf

A high-molecular-weight polymer used for film formation, texture or stabilisation. Meaningful dermal absorption is expected to be limited and no reproductive or developmental concern was identified for normal topical use.

Sources: CIR safety framework for cosmetic polymers; European Commission CosIng.

Cellulose-derived thickener and binder used to stabilise texture. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR Quick Reference Table / Cellulose Gum amended safety assessment; EU CosIng / cosmetics regulatory inventory

Skin-identical barrier lipid used to support the stratum corneum and reduce dryness. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Ceramides as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

pH adjuster used in small amounts to maintain product stability. Not associated with pregnancy-specific concerns.

Sources: Scientific Committee on Consumer Safety (EU); European cosmetics regulatory framework

An ivy-gourd fruit extract used for skin conditioning and antioxidant support. No pregnancy- or breastfeeding-specific hazard was identified for normal topical cosmetic exposure. Direct ingredient-specific pregnancy studies were not identified, so this assessment does not extend to oral supplements or medicinal use.

Sources: European Commission CosIng ingredient inventory; Cosmetic Ingredient Review botanical safety-assessment framework and relevant ingredient-family assessments. No ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

Copper-binding carrier peptide also known as GHK-Cu, used topically in cosmetic skin-renewal, anti-aging, barrier-support and hair/scalp products. Reviewed literature describes topical cosmetic use and does not identify a pregnancy- or breastfeeding-specific risk signal for normal topical use. This assessment does not apply to injectable copper peptides or oral peptide/copper supplementation.

Sources: Schagen SK. Topical Peptide Treatments with Effective Anti-Aging Results. Cosmetics. 2017;4(2):16. doi:10.3390/cosmetics4020016; Pickart L et al. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018;19(7):1987. doi:10.3390/ijms19071987.

A red-algae-derived extract used for skin conditioning, hydration or formula texture. Cosmetic safety reviewers concluded that the assessed red algae ingredients, including this extract, are safe in current practices of use and concentration. Cosmetic manufacturers should control naturally occurring contaminants such as heavy metals and arsenic.

Sources: CIR: Safety Assessment of Red Algae-Derived Ingredients as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=cef5b6e9-8c74-ec11-8943-0022482f06a6

Turmeric root extract is used for antioxidant and skin-conditioning effects. Pregnancy cautions relate mainly to concentrated oral supplements; normal topical cosmetic exposure is substantially smaller. The principal topical concern is irritation or allergy in sensitive users.

Sources: NIH NCCIH: Turmeric safety, including separate oral-supplement and topical cautions https://www.nccih.nih.gov/health/turmeric; European Commission CosIng ingredient inventory.

A plant-part extract used for skin conditioning, soothing, fragrance or antioxidant support. No pregnancy-specific systemic signal was identified for normal topical cosmetic exposure. This assessment does not extend to essential oils, oral herbal products or medicinal doses, and botanical sensitivity remains possible.

Sources: European Commission CosIng ingredient inventory; CIR botanical safety framework and relevant plant-derived ingredient assessments; peer-reviewed cosmetic-use literature.

Dipeptide-15 is glycylglycine, a small peptide made of two glycine units, not a growth factor or an unspecified polypeptide. Its defined structure and ordinary topical cosmetic exposure support No Known Risks; direct pregnancy studies are limited. This assessment does not assume that every peptide stays outside the skin. Cosmetic purity matters; injectable or medicinal peptide use is excluded.

Sources: https://kcia.or.kr/cid/search/ingd_view.php?no=494, https://pubchem.ncbi.nlm.nih.gov/compound/Glycylglycine

A functional cosmetic ingredient used for preservation support, pH control, chelation, solvent action or formula stability. Concentrated material may irritate skin or eyes, but no pregnancy-specific reproductive or developmental hazard was identified for normal use in a compliant finished cosmetic.

Sources: European Commission CosIng ingredient inventory and applicable cosmetic restrictions; relevant CIR ingredient and functional-family safety assessments.

Dipropylene glycol is used as a solvent and carrier in cosmetics; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Preservative booster and skin-conditioning agent. Considered safe for cosmetic use with low systemic exposure when used as intended.

Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)

A high-molecular-weight carbohydrate gum produced by microbial fermentation and used for hydration, texture or film formation. Cosmetic safety reviewers concluded that the assessed microbial polysaccharide gums are safe in current practices of use and concentration. Dermal absorption of the intact polymers is expected to be limited.

Sources: CIR: Safety Assessment of Microbial Polysaccharide Gums as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=c052d083-8e74-ec11-8943-0022482f06a6

An ethoxylated glycerin humectant used to retain moisture and improve product texture. The Cosmetic Ingredient Review assessed glycerin ethoxylates including Glycereth-26 for current cosmetic use; available evidence does not identify a pregnancy- or breastfeeding-specific concern from normal topical exposure.

Sources: CIR: Safety Assessment of Glycerin Ethoxylates https://cir-safety.org/supplementaldoc/safety-assessment-glycerin-ethoxylates-used-cosmetics

Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

Plant-derived emollient oil used to soften skin and support formula texture. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

Sources: CIR: Safety Assessment of Soy-Derived Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A soybean seed extract used for skin conditioning. Cosmetic safety reviewers concluded that the assessed Glycine soja-derived ingredients are safe in current practices. Soy sensitivity remains possible.

Sources: CIR: Glycine soja-derived ingredients conclusion, IJT 44(Suppl. 1), 2025; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Helianthus annuus (sunflower) seed oil is a common emollient rich in fatty acids and is generally well tolerated, with no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

A plant-derived oil or hydrogenated wax used mainly as an emollient and skin-conditioning ingredient. Cosmetic safety reviewers concluded that these named sea buckthorn, tea seed, jojoba and grape seed ingredients are safe in current practices of use and concentration. Plant allergy remains possible.

Sources: CIR: Hippophae Rhamnoides Oil, Camellia Sinensis Seed Oil, Hydrogenated Jojoba Oil and Vitis Vinifera (Grape) Seed Oil conclusions; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

High-water-binding humectant used to support hydration at the skin surface. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Hydrogenated emulsifier used to support skin barrier feel. Not associated with pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US)

Protein-derived skin- and hair-conditioning ingredient used to support feel and hydration at the surface. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.

Sources: CIR cosmetic ingredient safety references for protein hydrolysates; EU CosIng / cosmetics regulatory inventory

Humectant and skin-conditioning ingredient in the hyaluronate family. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Hydroxyacetophenone is used as an antioxidant and preservative-support ingredient; it is generally considered low concern in topical cosmetic use with no known pregnancy or breastfeeding risks at typical concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

A humectant that helps skin and hair retain water. Cosmetic safety reviewers concluded that hydroxyethyl urea is safe in current cosmetic use when formulated to be non-irritating; reproductive and developmental data reviewed for the assessment did not identify a pregnancy-specific concern from normal topical exposure.

Sources: CIR: Safety Assessment of Hydroxyethyl Urea https://www.cir-safety.org/supplementaldoc/safety-assessment-hydroxyethyl-urea-used-cosmetics-0

Inorganic salt used as a viscosity-control, bulking or stabilizing ingredient in cosmetics. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.

Sources: CIR cosmetic ingredient safety references for inorganic salts; EU CosIng / cosmetics regulatory inventory

Neem flower extract is used as a botanical skin-conditioning ingredient. A high-dose oral rat study altered the oestrous cycle and ovulation but did not show anti-implantation, abortifacient, or teratogenic effects. That oral dose does not establish a hazard from normal topical cosmetic exposure.

Sources: PubMed: high-dose oral neem flower extract reproductive study in rats https://pubmed.ncbi.nlm.nih.gov/19357745/; European Commission CosIng ingredient inventory. No human pregnancy study of normal topical cosmetic use was identified.

Neem leaf extract is used topically for skin conditioning and antimicrobial support. Reproductive concerns reported for concentrated neem seed preparations, intrauterine exposure, or high oral doses do not establish a hazard from normal topical cosmetic exposure to a leaf extract.

Sources: PubMed: oral purified neem seed extracts in primates https://pubmed.ncbi.nlm.nih.gov/8773426/; PubMed: intrauterine neem oil in primates https://pubmed.ncbi.nlm.nih.gov/8143455/; European Commission CosIng ingredient inventory. No human pregnancy study of normal topical cosmetic leaf-extract use was identified.

This plant-derived fatty oil or butter is used as an emollient and skin-conditioning ingredient. The Cosmetic Ingredient Review concluded that assessed plant-derived fatty acid oils are safe as used in cosmetics; individual plant allergy and ingredient purity remain practical considerations.

Sources: CIR: Safety Assessment of Plant-Derived Fatty Acid Oils https://cir-reports.cir-safety.org/view-attachment/?id=ad62ac6b-8e74-ec11-8943-0022482f06a6

Holy basil leaf extract is used for antioxidant and skin-conditioning purposes. Available warnings and pharmacology largely concern oral herbal use. No pregnancy-specific systemic hazard was identified for normal topical exposure to a compliant cosmetic, although botanical sensitivity remains possible.

Sources: PubMed: oral toxicological evaluation of Ocimum sanctum leaf extract https://pubmed.ncbi.nlm.nih.gov/24616736/; European Commission CosIng ingredient inventory. No human pregnancy study of topical cosmetic use was identified.

A fatty ester, lipid-derived emulsifier or emollient used for texture and skin conditioning. These materials have low expected systemic exposure, and no pregnancy-specific reproductive or developmental hazard was identified for normal topical cosmetic use.

Sources: CIR safety assessments of fatty esters, glycerides and emollients as used in cosmetics; European Commission CosIng ingredient inventory.

Panthenol (pro-vitamin B5) is used for soothing and barrier support and is generally well tolerated, with no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

Humectant and preservative booster. Considered safe for cosmetic use with low systemic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Silicone emollient used to improve slip, gloss, and water resistance. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Phenyl-Substituted Methicones as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A common inorganic electrolyte used to control viscosity, stabilise a formula or condition skin. At cosmetic concentrations these salts do not present a pregnancy-specific concern; concentrated formulas can still sting damaged or very sensitive skin.

Sources: European Commission CosIng ingredient inventory; PubChem compound records for potassium chloride, magnesium chloride and calcium chloride; established pharmaceutical and food use of these electrolytes.

A cosmetic functional ingredient used for conditioning, texture or formula support. Available cosmetic-use information did not identify a reproductive or developmental hazard from normal topical exposure.

Sources: European Commission CosIng ingredient inventory; relevant CIR cosmetic safety assessments and peer-reviewed cosmetic-use literature.

Solvent and humectant used to improve texture and ingredient solubility. Low systemic exposure expected from topical cosmetic use.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

pyrus malus juice is a botanical-derived cosmetic conditioning ingredient. The reviewed identity is not a concentrated essential oil or an oral herbal preparation. Available cosmetic evidence and expected topical exposure did not identify a pregnancy-specific contraindication, although botanical irritation or allergy remains possible.

Sources: CIR ingredient-specific and botanical-family safety assessments; CIR Quick Reference Table https://www.cir-safety.org/supplementaldoc/quick-reference-table-december-2025; European Commission CosIng

pyrus malus seed oil is a fixed plant oil used mainly as an emollient. CIR's plant-derived oil assessment supports cosmetic use, with refining, oxidation control and possible residual allergenic proteins remaining relevant. No pregnancy-specific concern was identified for normal topical exposure; this does not extend to concentrated essential oils or ingestion.

Sources: CIR Safety Assessment of Plant-Derived Fatty Acid Oils https://cir-safety.org/sites/default/files/118_final_oils_web.pdf; European Commission CosIng

Plant-derived emollient oil used to soften skin and improve formula feel. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

Sources: CIR: Final Report on the Safety Assessment of Simmondsia Chinensis (Jojoba) Seed Oil and related jojoba-derived ingredients; EU CosIng / cosmetics regulatory inventory

An alkaline mineral salt used for deodorising, buffering and mild abrasion. Cosmetic safety reviewers concluded that sodium bicarbonate is safe in current practices. It can irritate sensitive or freshly shaved skin in some formulas.

Sources: CIR: Sodium Bicarbonate conclusion, 2025; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Sodium chloride is used to adjust viscosity and texture in formulations; topical cosmetic use is considered low concern with no known pregnancy or breastfeeding risks.

Sources: CIR; EU/UK Cosmetics Regulation

Buffering and chelating ingredient used to control pH and formulation stability. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Citric Acid, Inorganic Citrate Salts, and Alkyl Citrate Esters as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Sodium hyaluronate (hyaluronic acid salt) is used for hydration and cushioning, with very low systemic absorption from topical use and no known pregnancy or breastfeeding concerns at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Amino-acid-derived emulsifier and skin-conditioning support ingredient. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.

Sources: CIR cosmetic ingredient safety references for amino acid alkyl amides/salts; EU CosIng / cosmetics regulatory inventory

A fruit, seed or food-plant extract used for skin conditioning and antioxidant support. No pregnancy-specific signal was identified for the low topical exposure expected from a finished cosmetic. Direct pregnancy studies are generally unavailable, and botanical allergy remains possible.

Sources: European Commission CosIng ingredient inventory; CIR botanical safety framework and relevant fruit-derived ingredient assessments; peer-reviewed cosmetic and phytochemical literature for the named plants.

streptococcus thermophilus ferment is a non-live fermentation-derived or microbial-lysate cosmetic ingredient. CIR assessments of Lactobacillus and yeast-derived cosmetic materials support use under current formulation practices. No pregnancy-specific concern was identified for normal topical use; this does not assess live organisms or oral supplements.

Sources: CIR Safety Assessment of Lactobacillus Ferment Ingredients https://cir-safety.org/supplementaldoc/safety-assessment-lactobacillus-ferment-ingredients-used-cosmetics; CIR yeast-derived ingredient assessment.

Vitamin E antioxidant used to protect oils and support the skin barrier. Not associated with pregnancy-specific concerns at cosmetic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Water (Aqua) is the standard purified water used as a cosmetic solvent. It has no pregnancy-specific risk in normal topical use.

Sources: https://pubchem.ncbi.nlm.nih.gov/compound/Water, https://single-market-economy.ec.europa.eu/sectors/cosmetics/cosmetic-ingredient-database/cosing-glossary-ingredients_en

Natural polysaccharide thickener used for stability and texture. Not associated with pregnancy-specific concerns.

Sources: European cosmetics regulatory framework

Sugar alcohol humectant used to help maintain hydration and improve skin feel. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Mannitol, Sorbitol, and Xylitol as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A sugar-derived humectant commonly used with xylitol and anhydroxylitol to support skin hydration. Exact pregnancy-specific topical data are limited. Cosmetic safety assessments of the related saccharide mixture and xylitol did not identify a reproductive or pregnancy-specific concern at cosmetic exposure; available data primarily support local tolerance rather than proving pregnancy safety. No topical contraindication was identified in the reviewed material.

Sources: CIR: Safety Assessment of Saccharide Isomerate and Related Saccharides https://cir-safety.org/supplementaldoc/safety-assessment-anhydrogalactose-anhydroglucitol-anhydroxylitol-arabinose-psicose-; CIR: Safety Assessment of Mannitol, Sorbitol, and Xylitol https://www.cir-safety.org/sites/default/files/xylito122019FR.pdf