Ginseng Skin Barrier Serum

Niacinamide (vitamin B3) is widely used for barrier support and tone/texture benefits, and is generally considered safe in pregnancy and breastfeeding when used topically at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Solvent and humectant used to improve texture and ingredient delivery in topical cosmetic formulas. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.

Sources: CIR cosmetic ingredient safety references for alkane diols; EU CosIng / cosmetics regulatory inventory

Solvent and humectant used to improve texture and ingredient solubility. Low systemic exposure expected from topical cosmetic use.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Sugar-derived humectant used to help bind water and improve skin feel. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.

Sources: CIR: Safety Assessment of Monosaccharides, Disaccharides, and Related Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Polymer thickener used to create gel textures. Large-molecule ingredient with negligible systemic absorption.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

pH adjuster and buffer used to stabilise formulations. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Tromethamine as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

corchorus olitorius leaf extract is a botanical-derived cosmetic conditioning ingredient. The reviewed identity is not a concentrated essential oil or an oral herbal preparation. Available cosmetic evidence and expected topical exposure did not identify a pregnancy-specific contraindication, although botanical irritation or allergy remains possible.

Sources: CIR ingredient-specific and botanical-family safety assessments; CIR Quick Reference Table https://www.cir-safety.org/supplementaldoc/quick-reference-table-december-2025; European Commission CosIng

nelumbo nucifera root extract is a botanical-derived cosmetic conditioning ingredient. The reviewed identity is not a concentrated essential oil or an oral herbal preparation. Available cosmetic evidence and expected topical exposure did not identify a pregnancy-specific contraindication, although botanical irritation or allergy remains possible.

Sources: CIR ingredient-specific and botanical-family safety assessments; CIR Quick Reference Table https://www.cir-safety.org/supplementaldoc/quick-reference-table-december-2025; European Commission CosIng

A botanical extract or plant water used for conditioning, soothing or antioxidant support. Direct pregnancy studies of this exact cosmetic material were not identified, but no reproductive or developmental hazard was identified for normal topical exposure. Oral herbal or medicinal use is outside this classification.

Sources: European Commission CosIng; CIR botanical safety framework and relevant plant-family assessments; no ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

A Japanese-yam root extract used as a moisturising and skin-conditioning botanical. No pregnancy- or breastfeeding-specific hazard was identified for normal topical cosmetic exposure. Direct ingredient-specific pregnancy studies were not identified, so this assessment does not extend to oral supplements or medicinal use.

Sources: European Commission CosIng ingredient inventory; Cosmetic Ingredient Review botanical safety-assessment framework and relevant ingredient-family assessments. No ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

No pregnancy-specific harm has been identified for ordinary, correctly formulated topical cosmetic use of angelica keiskei extract. This is a bounded botanical/extract assessment; direct pregnancy studies of the exact material are limited and oral, medicinal, damaged-skin or aerosol exposure is not included.

Sources: https://www.cir-safety.org/sites/default/files/Botanical%20Decision%20Tree%20CIR%20June%202012%202.pdf

Polymer used for texture and absorbency. Large-molecule ingredient with low systemic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Preservative booster and skin-conditioning agent. Considered safe for cosmetic use with low systemic exposure when used as intended.

Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)

Skin-conditioning ingredient commonly used in leave-on skincare. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Adenosine Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Natural polysaccharide thickener used for stability and texture. Not associated with pregnancy-specific concerns.

Sources: European cosmetics regulatory framework

Starch-derived polysaccharide used as a binder, film former and texture support ingredient. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.

Sources: CIR cosmetic ingredient safety references for polysaccharides/starch-derived ingredients; EU CosIng / cosmetics regulatory inventory

A fruit, seed or food-plant extract used for skin conditioning and antioxidant support. No pregnancy-specific signal was identified for the low topical exposure expected from a finished cosmetic. Direct pregnancy studies are generally unavailable, and botanical allergy remains possible.

Sources: European Commission CosIng ingredient inventory; CIR botanical safety framework and relevant fruit-derived ingredient assessments; peer-reviewed cosmetic and phytochemical literature for the named plants.

Neem flower extract is used as a botanical skin-conditioning ingredient. A high-dose oral rat study altered the oestrous cycle and ovulation but did not show anti-implantation, abortifacient, or teratogenic effects. That oral dose does not establish a hazard from normal topical cosmetic exposure.

Sources: PubMed: high-dose oral neem flower extract reproductive study in rats https://pubmed.ncbi.nlm.nih.gov/19357745/; European Commission CosIng ingredient inventory. No human pregnancy study of normal topical cosmetic use was identified.

Disodium EDTA is a chelating agent used to improve formula stability and performance; it is considered low concern in topical cosmetic use, with no known pregnancy or breastfeeding risks at typical concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Holy basil leaf extract is used for antioxidant and skin-conditioning purposes. Available warnings and pharmacology largely concern oral herbal use. No pregnancy-specific systemic hazard was identified for normal topical exposure to a compliant cosmetic, although botanical sensitivity remains possible.

Sources: PubMed: oral toxicological evaluation of Ocimum sanctum leaf extract https://pubmed.ncbi.nlm.nih.gov/24616736/; European Commission CosIng ingredient inventory. No human pregnancy study of topical cosmetic use was identified.

A high-molecular-weight polymer used to hold water and stabilise texture. Cosmetic safety reviewers concluded that glyceryl acrylate/acrylic acid copolymer is safe in current cosmetic practices. Dermal absorption of the finished polymer is expected to be limited; residual monomers should be controlled by cosmetic manufacturing standards.

Sources: CIR: Safety Assessment of Glyceryl Acrylate/Acrylic Acid Copolymer and Glyceryl Polyacrylate https://cir-reports.cir-safety.org/view-attachment/?id=c79ac89b-d78d-055f-ba88-45f4f5a039b3

Neem leaf extract is used topically for skin conditioning and antimicrobial support. Reproductive concerns reported for concentrated neem seed preparations, intrauterine exposure, or high oral doses do not establish a hazard from normal topical cosmetic exposure to a leaf extract.

Sources: PubMed: oral purified neem seed extracts in primates https://pubmed.ncbi.nlm.nih.gov/8773426/; PubMed: intrauterine neem oil in primates https://pubmed.ncbi.nlm.nih.gov/8143455/; European Commission CosIng ingredient inventory. No human pregnancy study of normal topical cosmetic leaf-extract use was identified.

A botanical root extract used as a skin-conditioning and antioxidant ingredient. Cosmetic safety reviewers concluded that Panax root-derived ingredients are safe in current practices of use and concentration. The assessment considered the biological activity of ginsenosides and available reproductive and developmental information; ordinary topical cosmetic exposure was not identified as a pregnancy-specific concern. Botanical irritation or allergy remains possible.

Sources: CIR: Safety Assessment of Panax spp. Root-Derived Ingredients as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-panax-spp-root-derived-ingredients-used-cosmetics

Sodium hyaluronate (hyaluronic acid salt) is used for hydration and cushioning, with very low systemic absorption from topical use and no known pregnancy or breastfeeding concerns at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Turmeric root extract is used for antioxidant and skin-conditioning effects. Pregnancy cautions relate mainly to concentrated oral supplements; normal topical cosmetic exposure is substantially smaller. The principal topical concern is irritation or allergy in sensitive users.

Sources: NIH NCCIH: Turmeric safety, including separate oral-supplement and topical cautions https://www.nccih.nih.gov/health/turmeric; European Commission CosIng ingredient inventory.

A red-algae-derived extract used for skin conditioning, hydration or formula texture. Cosmetic safety reviewers concluded that the assessed red algae ingredients, including this extract, are safe in current practices of use and concentration. Cosmetic manufacturers should control naturally occurring contaminants such as heavy metals and arsenic.

Sources: CIR: Safety Assessment of Red Algae-Derived Ingredients as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=cef5b6e9-8c74-ec11-8943-0022482f06a6

Film-forming polysaccharide used for soothing and hydration support. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Microbial Polysaccharide Gums as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A Chinese skullcap root extract used for skin conditioning and antioxidant effects. Cosmetic safety reviewers concluded that the root extract is safe in current practices of use and concentration; this conclusion does not extend to the generic whole-plant or sprout extracts, for which evidence was insufficient. No pregnancy-specific concern was identified for normal topical cosmetic exposure.

Sources: CIR: Safety Assessment of Scutellaria baicalensis-Derived Ingredients as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=12155820-bce2-80f8-bd06-353ba20e5877

Botanical skin-conditioning ingredient used in soothing and barrier-support formulas. Reviewed cosmetic safety sources support current cosmetic use when formulated to be non-sensitising, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

Sources: CIR: Safety Assessment of Centella asiatica-derived Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Cationic hyaluronate derivative used as a humectant and conditioning ingredient. Reviewed topical hyaluronate safety sources support cosmetic use, with no pregnancy- or breastfeeding-specific concern identified.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A mushroom-derived conditioning extract. No pregnancy-specific hazard was identified for normal topical exposure; source allergy remains possible.

Sources: European Commission CosIng; CIR biological-source ingredient framework; peer-reviewed fungal-extract literature.

Vitamin E antioxidant used to protect oils and support the skin barrier. Not associated with pregnancy-specific concerns at cosmetic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Modified hyaluronate humectant and skin-conditioning ingredient. Reviewed cosmetic safety sources support topical hyaluronate ingredients, with no pregnancy- or breastfeeding-specific concern identified for normal cosmetic use.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Humectant and skin-conditioning ingredient in the hyaluronate family. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

High-water-binding humectant used to support hydration at the skin surface. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Crosslinked hyaluronate humectant used to support hydration at the skin surface. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Humectant and skin-conditioning ingredient in the hyaluronate family. Reviewed cosmetic safety sources support current cosmetic use, with no pregnancy- or breastfeeding-specific topical concern identified in the material reviewed.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Potassium hyaluronate is a salt of hyaluronic acid used as a surface humectant and skin conditioner. The Cosmetic Ingredient Review concluded that reviewed hyaluronates are safe in current cosmetic use, with no pregnancy- or breastfeeding-specific concern identified for normal topical exposure.

Sources: CIR: Safety Assessment of Hyaluronates as Used in Cosmetics https://www.cir-safety.org/supplementaldoc/safety-assessment-hyaluronates-used-cosmetics