5% Blueberry Moisturizer Cream

Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Inert synthetic emollient used as a glossing and occlusive agent. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Polyene Group as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A propylene-glycol fatty-acid ester used as an emollient and dispersing agent. Cosmetic safety reviewers concluded that the assessed propylene glycol esters are safe in current practices when formulated to be non-irritating. No pregnancy-specific concern was identified for normal topical exposure.

Sources: CIR: Safety Assessment of Propylene Glycol Esters as Used in Cosmetics https://www.cir-safety.org/supplementaldoc/safety-assessment-propylene-glycol-esters-used-cosmetics

Silicone emollient and solvent used to improve slip and spreadability. No known pregnancy- or breastfeeding-specific concern in normal topical cosmetic use based on reviewed cosmetic safety sources. Spray or aerosol formats may warrant extra caution because inhalation/local lung exposure concerns have been raised for those uses.

Sources: SCCS: Cyclopentasiloxane (D5) in cosmetic products; EU CosIng / cosmetics regulatory inventory

Skin-identical barrier lipid used to support barrier structure and reduce dryness. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Ceramides as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Skin-identical barrier lipid used to support barrier function and reduce dryness. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Ceramides as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

A skin-identical barrier lipid used for skin and hair conditioning. Cosmetic safety reviewers concluded that Ceramide NS is safe in current cosmetic use, noting limited skin absorption and reassuring toxicity data. Cosmetic-grade material should not be sourced from bovine central nervous system tissue.

Sources: CIR: Safety Assessment of Ceramides https://cir-safety.org/sites/default/files/cerami122014tent.pdf

A skin-identical barrier lipid used for skin and hair conditioning. Cosmetic safety reviewers concluded that Ceramide NG is safe in current cosmetic use, noting limited skin absorption and reassuring toxicity data. Cosmetic-grade material should not be sourced from bovine central nervous system tissue.

Sources: CIR: Safety Assessment of Ceramides https://www.cir-safety.org/supplementaldoc/safety-assessment-ceramides-used-cosmetics-0

A skin-identical barrier lipid used for skin and hair conditioning. Cosmetic safety reviewers concluded that Ceramide AS is safe in current cosmetic use, noting limited skin absorption and reassuring toxicity data. Cosmetic-grade material should not be sourced from bovine central nervous system tissue.

Sources: CIR: Safety Assessment of Ceramides https://www.cir-safety.org/supplementaldoc/safety-assessment-ceramides-used-cosmetics-0

Sodium hyaluronate (hyaluronic acid salt) is used for hydration and cushioning, with very low systemic absorption from topical use and no known pregnancy or breastfeeding concerns at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

A leaf extract used in soothing and skin-conditioning formulas. Cosmetic safety reviewers concluded that Centella asiatica leaf extract is safe at current cosmetic exposure when products are formulated to be non-sensitising. The assessment considered systemic and reproductive findings reported at substantially higher oral exposures; these did not establish a pregnancy-specific concern for ordinary topical cosmetic use. Centella constituents can still cause contact sensitivity in some people.

Sources: CIR: Safety Assessment of Centella asiatica-Derived Ingredients as Used in Cosmetics https://cir-safety.org/supplementaldoc/safety-assessment-centella-asiatica-derived-ingredients-used-cosmetics-1

Polymer thickener used to stabilise emulsions. Large-molecule ingredient with low systemic absorption.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Hydroxyacetophenone is used as an antioxidant and preservative-support ingredient; it is generally considered low concern in topical cosmetic use with no known pregnancy or breastfeeding risks at typical concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Betaine is a humectant/osmolyte used to support hydration and reduce irritation potential in formulas; it is considered low concern with no known pregnancy or breastfeeding risks in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

Allantoin is a soothing skin protectant commonly used to help reduce irritation and support comfort, with no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

A high-molecular-weight ester used as an emollient and film-forming texture agent. Cosmetic safety reviewers concluded that trialkyl trimellitates, including tridecyl trimellitate, are safe in current practices when formulated to be non-irritating. Dermal absorption is expected to be limited.

Sources: CIR: Safety Assessment of Trialkyl Trimellitates as Used in Cosmetics https://www.cir-safety.org/sites/default/files/trimel062015TR.pdf

Large polymer thickener, stabilizer and texture ingredient used in gels, creams and sunscreens. Systemic exposure from topical cosmetic use is expected to be low, with no pregnancy- or breastfeeding-specific concern identified in reviewed cosmetic references.

Sources: CIR cosmetic ingredient safety references for acrylates copolymers; EU CosIng / cosmetics regulatory inventory

Lightweight emollient used to support the skin barrier. Not associated with pregnancy-specific concerns at cosmetic exposure levels.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Sugar-derived humectant used to help bind water and improve skin feel. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.

Sources: CIR: Safety Assessment of Monosaccharides, Disaccharides, and Related Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Sophora flavescens root extract contains variable botanical alkaloids and is used for skin conditioning. Pharmacological and toxicity findings from oral extracts or isolated constituents do not establish a reproductive hazard from normal topical cosmetic exposure.

Sources: European Commission CosIng ingredient inventory; PubMed phytochemical and toxicology literature on Sophora flavescens and matrine-family alkaloids. No human pregnancy study of topical cosmetic use was identified.

A cosmetic extract from an edible fruit, seed, grain, root or mushroom used for conditioning or antioxidant support. Normal topical cosmetic exposure is much lower than ordinary dietary exposure to the source material, and no pregnancy-specific hazard signal was identified. Exact extract composition varies, so source quality and individual food or plant allergy remain relevant.

Sources: European Commission CosIng ingredient inventory; CIR botanical safety framework and relevant plant-derived ingredient assessments; FDA food ingredient and GRAS inventories where applicable.

A botanical extract or plant water used for conditioning, soothing or antioxidant support. Direct pregnancy studies of this exact cosmetic material were not identified, but no reproductive or developmental hazard was identified for normal topical exposure. Oral herbal or medicinal use is outside this classification.

Sources: European Commission CosIng; CIR botanical safety framework and relevant plant-family assessments; no ingredient-specific human pregnancy study of normal topical cosmetic use was identified.

Humectant and preservative booster. Considered safe for cosmetic use with low systemic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

For ordinary, correctly formulated topical cosmetic use, no pregnancy-specific harm has been identified for panicum miliaceum seed extract. Millet seed botanical extract; ordinary topical dose low, not a medicinal oral botanical claim. Direct pregnancy studies of this exact material are limited; this assessment does not cover ingestion, medicinal-strength use, damaged skin, or aerosol exposure.

Sources: https://www.cir-safety.org/sites/default/files/Botanical%20Decision%20Tree%20CIR%20June%202012%202.pdf

secale cereale seed extract is a botanical-derived cosmetic conditioning ingredient. The reviewed identity is not a concentrated essential oil or an oral herbal preparation. Available cosmetic evidence and expected topical exposure did not identify a pregnancy-specific contraindication, although botanical irritation or allergy remains possible.

Sources: CIR ingredient-specific and botanical-family safety assessments; CIR Quick Reference Table https://www.cir-safety.org/supplementaldoc/quick-reference-table-december-2025; European Commission CosIng

A soybean seed extract used for skin conditioning. Cosmetic safety reviewers concluded that the assessed Glycine soja-derived ingredients are safe in current practices. Soy sensitivity remains possible.

Sources: CIR: Glycine soja-derived ingredients conclusion, IJT 44(Suppl. 1), 2025; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Vitamin E antioxidant used to protect oils and support the skin barrier. Not associated with pregnancy-specific concerns at cosmetic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Skin-identical barrier lipid used to support the stratum corneum and reduce dryness. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Ceramides as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

For ordinary, correctly formulated topical cosmetic use, no pregnancy-specific harm has been identified for castanea sativa seed extract. Chestnut seed extract is food-derived but differs from shell extract; nut allergy is possible. Direct pregnancy studies of this exact material are limited; this assessment does not cover ingestion, medicinal-strength use, damaged skin, or aerosol exposure.

Sources: https://www.cir-safety.org/sites/default/files/Botanical%20Decision%20Tree%20CIR%20June%202012%202.pdf

A fruit, seed or food-plant extract used for skin conditioning and antioxidant support. No pregnancy-specific signal was identified for the low topical exposure expected from a finished cosmetic. Direct pregnancy studies are generally unavailable, and botanical allergy remains possible.

Sources: European Commission CosIng ingredient inventory; CIR botanical safety framework and relevant fruit-derived ingredient assessments; peer-reviewed cosmetic and phytochemical literature for the named plants.

A sunflower seed extract used mainly for skin conditioning. Cosmetic safety reviewers concluded that the supported Helianthus annuus-derived ingredients are safe in current cosmetic practices of use and concentration. A person with sunflower allergy may still react, but no pregnancy-specific concern was identified for normal topical exposure.

Sources: CIR: Safety Assessment of Helianthus annuus-Derived Ingredients as Used in Cosmetics https://www.cir-safety.org/sites/default/files/Helianthus%20annuus.pdf

Polysaccharide carrier and bulking agent used for texture and delivery support. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Polysaccharide Gums as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Hydrogenated emulsifier used to support skin barrier feel. Not associated with pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US)

A high-molecular-weight silicone polymer used for film forming, smoothing and skin or hair conditioning. The Cosmetic Ingredient Review concluded that Dimethiconol and its assessed derivatives are safe in current cosmetic use. Its polymeric nature limits skin penetration, and available evidence does not identify a pregnancy- or breastfeeding-specific concern for normal topical exposure.

Sources: CIR: Safety Assessment of Dimethiconol and its Esters and Reaction Products; International Journal of Toxicology 36(Suppl. 3):31-50 (2017) https://cir-safety.org/ingredient/dimethiconol

1,2-Hexanediol is commonly used as a solvent and preservative booster; topical exposure is low and it has no known pregnancy or breastfeeding concerns at cosmetic concentrations, though very sensitive skin may occasionally react.

Sources: CIR; EU/UK Cosmetics Regulation

Nonionic emulsifier and solubilizer used to help oil and water phases mix. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified.

Sources: CIR: Safety Assessment of Polysorbates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Emulsifier used to help oil and water phases remain mixed. Reviewed cosmetic safety sources support topical use in cosmetics; the main practical issue is irritation potential in some formulas rather than a pregnancy-specific concern.

Sources: CIR: Safety Assessment of Sorbitan Esters as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Natural polysaccharide thickener used for stability and texture. Not associated with pregnancy-specific concerns.

Sources: European cosmetics regulatory framework

Disodium EDTA is a chelating agent used to improve formula stability and performance; it is considered low concern in topical cosmetic use, with no known pregnancy or breastfeeding risks at typical concentrations.

Sources: CIR; EU/UK Cosmetics Regulation