La Roche-Posay Effaclar Duo+M by La Roche-Posay
La Roche-Posay

La Roche-Posay Effaclar Duo+M

General Moisturizersmoisturisers

Safety score

Pregnancy-focused assessment

Low Risk72/100
Higher concernLower concern

One or more ingredients have a low-risk flag in MamaSkin's current assessment. Review the notes and your own circumstances.

Ingredient safety review updated 7 January 2026.

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Ingredient breakdown

See how the listed formula falls across MamaSkin's pregnancy-focused risk bands.

31

No known risks

4

Low risk

0

Medium risk

0

High risk

Ingredients

Ingredients with a higher risk flag appear first, followed by the rest of the formula.

Parfum

Low Risk

Umbrella term for an undisclosed fragrance blend. It’s not usually a pregnancy-specific concern at normal cosmetic use levels, but the exact components and concentrations aren’t fully disclosed on the label, so we score it more conservatively. If you prefer maximum transparency (or you’re sensitive to fragrance compounds), choose fragrance-free/unscented products.

Sources: EU/UK cosmetics (fragrance allergen labelling); IFRA

Capryloyl Salicylic Acid

Low Risk

Salicylate derivative used in cosmetics; low-strength topical use has low systemic absorption and is generally considered low risk in pregnancy. Avoid high-strength peels/large-area use.

Sources: PubMed, U.S. National Library of Medicine (NLM), NHS, MotherToBaby (OTIS), UKTIS (BUMPS)

Dimethicone

Low Risk

Dimethicone is a silicone polymer used as a skin protectant and slip/conditioning agent. It is considered inert with minimal dermal absorption; the main practical issues are cosmetic (feel) and occasional irritation in very sensitive users. It is not a pregnancy-specific concern in topical cosmetic use.

Sources: CIR: Safety Assessment of Dimethicone, Methicone, and related ingredients as used in cosmetics (Methicones report; 2019/2022 update); EU CosIng entry for Dimethicone.

Show all (35)

Salicylic Acid

Low Risk

Salicylic acid is a beta hydroxy acid used for exfoliation. Low-strength topical use (up to 2%) on limited areas is generally considered low risk. Higher concentrations, large-area use, or professional peels are avoided during pregnancy due to systemic absorption concerns.

Sources: PubMed, U.S. National Library of Medicine (NLM), NHS, MotherToBaby (OTIS), UKTIS (BUMPS)

2-Oleamido-1,3-Octadecanediol

No Known Risks

Acrylamide/Sodium Acryloyldimethyltaurate Copolymer

No Known Risks

A high-molecular-weight polymer used to thicken and stabilise formulas. Cosmetic safety reviewers concluded that acryloyldimethyltaurate polymers are safe in current practices. Residual monomers should be controlled during manufacture.

Sources: CIR: Acryloyldimethyltaurate Polymers final assessment, April 2017; December 2025 Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Ammonium Polyacryloyldimethyl Taurate

No Known Risks

A high-molecular-weight polymer used to thicken and stabilise formulas. Cosmetic safety reviewers concluded that acryloyldimethyltaurate polymers are safe in current cosmetic practices. Absorption of the finished polymer is expected to be limited, with residual monomers controlled during manufacture.

Sources: CIR: Safety Assessment of Acryloyldimethyltaurate Polymers as Used in Cosmetics; final report April 2017 https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Caprylyl Glycol

No Known Risks

Humectant and preservative booster used to support product stability. Low systemic exposure expected from topical cosmetic use.

Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)

Citric Acid

No Known Risks

pH adjuster used in small amounts to maintain product stability. Not associated with pregnancy-specific concerns.

Sources: Scientific Committee on Consumer Safety (EU); European cosmetics regulatory framework

Glycerin

No Known Risks

Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

Glyceryl Stearate Se

No Known Risks

Self-emulsifying form of glyceryl stearate used to stabilize creams and lotions. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific concern identified.

Sources: CIR cosmetic ingredient safety references for glyceryl stearate and self-emulsifying emulsifiers; EU CosIng / cosmetics regulatory inventory

Hydroxyethoxyphenyl Butanone

No Known Risks

Isocetyl Stearate

No Known Risks

Isohexadecane

No Known Risks

Low-viscosity isoparaffin emollient used for slip and lightweight texture. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Isoparaffins as Used in Cosmetics / CIR Quick Reference Table (Isohexadecane); EU CosIng / cosmetics regulatory inventory

Isopropyl Lauroyl Sarcosinate

No Known Risks

Maltodextrin

No Known Risks

Polysaccharide carrier and bulking agent used for texture and delivery support. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Polysaccharide Gums as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Mannose

No Known Risks

Myristyl Myristate

No Known Risks

A fatty-acid ester used mainly for emollience, slip and formula texture. Cosmetic safety reviewers concluded that the assessed alkyl esters are safe in current practices when formulated to be non-irritating. No pregnancy-specific concern was identified for normal topical cosmetic exposure.

Sources: CIR: Safety Assessment of Alkyl Esters as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=b34bc38f-8e74-ec11-8943-0022482f06a6

Niacinamide

No Known Risks

Niacinamide (vitamin B3) is widely used for barrier support and tone/texture benefits, and is generally considered safe in pregnancy and breastfeeding when used topically at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Oryza Sativa Starch

No Known Risks

A plant-derived carbohydrate polymer or modified starch used to thicken, stabilise or condition a formula. Cosmetic safety reviewers concluded that the supported plant polysaccharide gums and derivatives are safe in current practices of use and concentration. Loose powders should still be used without deliberately inhaling airborne particles.

Sources: CIR: Safety Assessment of Plant Polysaccharide Gums as Used in Cosmetics https://www.cir-safety.org/panelbook/safety-assessment-plant-polysaccharide-gums-used-cosmetics

Pentylene Glycol

No Known Risks

Humectant and preservative booster. Considered safe for cosmetic use with low systemic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Piroctone Olamine

No Known Risks

Poloxamer 338

No Known Risks

Polysorbate 80

No Known Risks

Nonionic emulsifier and solubilizer used to disperse oils in cosmetic formulas. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified.

Sources: CIR: Safety Assessment of Polysorbates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Potassium Cetyl Phosphate

No Known Risks

An alkyl phosphate surfactant and emulsifier used to stabilise creams, sunscreens and makeup. Cosmetic safety reviewers concluded that the assessed alkyl phosphates, including potassium cetyl phosphate, are safe in current practices of use and concentration when formulated to be non-irritating. Dermal penetration is expected to be limited, and no pregnancy-specific concern is identified for normal topical cosmetic exposure.

Sources: CIR: Safety Assessment of Alkyl Phosphates https://www.cir-safety.org/sites/default/files/alkyl%20phosphates_0.pdf

Propanediol

No Known Risks

Solvent and humectant used to improve texture and ingredient solubility. Low systemic exposure expected from topical cosmetic use.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Punica Granatum Pericarp Extract

No Known Risks

Silica

No Known Risks

Mineral absorbent and texture aid used to mattify and improve slip. Reviewed cosmetic safety sources support normal topical cosmetic use; this assessment does not cover deliberate inhalation of loose powder.

Sources: CIR: Safety Assessment of Silica and Silicates as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Sodium Hydroxide

No Known Risks

pH adjuster used in very small quantities to balance formulations. Not associated with pregnancy-specific concerns.

Sources: Scientific Committee on Consumer Safety (EU); European cosmetics regulatory framework

Sorbitan Oleate

No Known Risks

This sorbitan fatty-acid ester is an emulsifier that helps oil and water phases remain mixed. The Cosmetic Ingredient Review concluded that sorbitan esters are safe in current cosmetic use; occasional contact reactions remain possible in sensitive users.

Sources: CIR: Safety Assessment of Sorbitan Esters as Used in Cosmetics https://www.cir-safety.org/supplementaldoc/safety-assessment-sorbitan-esters-used-cosmetics

Trisodium Ethylenediamine Disuccinate

No Known Risks

Chelating ingredient used to improve formula stability by binding trace metals. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.

Sources: CIR cosmetic ingredient safety references for chelating agents; EU CosIng / cosmetics regulatory inventory

Vitreoscilla Ferment

No Known Risks

Water

No Known Risks

Xanthan Gum

No Known Risks

Natural polysaccharide thickener used for stability and texture. Not associated with pregnancy-specific concerns.

Sources: European cosmetics regulatory framework

Zinc Pca

No Known Risks

A zinc salt of pyrrolidone carboxylic acid used for skin conditioning, oil-control and antimicrobial support. Cosmetic safety reviewers concluded that the assessed zinc salts are safe in current cosmetic practices of use and concentration when formulated to be non-irritating. Zinc is an essential nutrient, but this entry assesses the low topical exposure from a finished cosmetic rather than supplements or medicinal doses. No pregnancy-specific topical concern was identified.

Sources: CIR: Safety Assessment of Zinc Salts as Used in Cosmetics https://www.cir-safety.org/supplementaldoc/safety-assessment-zinc-salts-used-cosmetics-1; CIR 146th Expert Panel Meeting final report record https://www.cir-safety.org/meeting/146th-cir-expert-panel-meeting

Formulations can change without notice. For the most accurate result, compare this list with your packaging and scan the exact ingredient label in MamaSkin when you repurchase.

How to use this assessment

The risk band is the primary conclusion. The score adds detail within that band and should not be used to compare products as if a one-point difference were clinically meaningful.

MamaSkin provides pregnancy-focused information, not medical advice. Your midwife, GP, pharmacist or dermatologist should take priority when your circumstances differ from typical cosmetic use.

Read the full methodology