Kiehl's Retinol Skin-Renewing Daily Micro-Dose Serum by Kiehl's
Kiehl's

Kiehl's Retinol Skin-Renewing Daily Micro-Dose Serum

Serums

Safety score

Pregnancy-focused assessment

High Risk26/100
Higher concernLower concern

This formula contains a higher-risk ingredient in MamaSkin's current pregnancy-focused assessment.

Formula and assessment check

Ingredient safety review updated 10 April 2026. Product formulas can change, so compare the ingredients shown here with the packaging you have.

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Ingredient breakdown

See how the listed formula falls across MamaSkin's pregnancy-focused risk bands.

41

No known risks

1

Low risk

0

Medium risk

1

High risk

Ingredients

Ingredients with a higher risk flag appear first, followed by the rest of the formula.

Retinol

High Risk

Vitamin A derivative. Systemic retinoids are known teratogens, and topical retinoids are avoided during pregnancy due to class-wide risk and limited safety margins. Avoid use during pregnancy regardless of formulation.

Sources: EMA: Updated measures for pregnancy prevention during retinoid use https://www.ema.europa.eu/en/news/updated-measures-pregnancy-prevention-during-retinoid-use; FDA: Pregnancy and Lactation Labeling Rule https://www.fda.gov/drugs/labeling-information-drug-products/questions-and-answers-pregnancy-and-lactation-labeling-rule

Phenoxyethanol.

Low Risk

Phenoxyethanol is a preservative permitted in EU cosmetics up to 1.0%. The SCCS concluded it is safe for cosmetic use at that level, including when considering higher cosmetic exposure scenarios in infants and young children. Main practical concern is irritation/stinging on very sensitive or compromised skin rather than a pregnancy- or breastfeeding-specific risk.

Sources: SCCS/1575/16: Phenoxyethanol opinion https://health.ec.europa.eu/publications/phenoxyethanol_en

Aqua / Water

No Known Risks
Show all (43)

Glycerin

No Known Risks

Glycerin is a widely used humectant that supports hydration and the skin barrier, with a long safety record and no known pregnancy or breastfeeding concerns in topical cosmetic use.

Sources: CIR; EU/UK Cosmetics Regulation

Butylene Glycol

No Known Risks

Solvent and humectant commonly used in leave-on products. Not associated with pregnancy-specific concerns at cosmetic exposure levels.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Pentylene Glycol

No Known Risks

Humectant and preservative booster. Considered safe for cosmetic use with low systemic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Niacinamide

No Known Risks

Niacinamide (vitamin B3) is widely used for barrier support and tone/texture benefits, and is generally considered safe in pregnancy and breastfeeding when used topically at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Cetyl Alcohol

No Known Risks

Fatty alcohol used to improve texture and skin feel. Considered safe for cosmetic use without pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Isohexadecane

No Known Risks

Low-viscosity isoparaffin emollient used for slip and lightweight texture. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Isoparaffins as Used in Cosmetics / CIR Quick Reference Table (Isohexadecane); EU CosIng / cosmetics regulatory inventory

Isononyl Isononanoate

No Known Risks

Emollient ester used for lightweight slip and a dry skin feel in makeup and skin care. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.

Sources: CIR cosmetic ingredient safety references for alkyl esters/emollient esters; EU CosIng / cosmetics regulatory inventory

Diisopropyl Sebacate

No Known Risks

An ester of a dicarboxylic acid used as an emollient, solvent or texture agent. Cosmetic safety reviewers concluded that the assessed alkyl dicarboxylic acid esters are safe in current practices of use and concentration. No pregnancy-specific concern was identified for normal topical exposure.

Sources: CIR: Safety Assessment of Alkyl Dicarboxylic Acid Esters as Used in Cosmetics https://cir-reports.cir-safety.org/view-attachment/?id=d8d3785f-8e74-ec11-8943-0022482f06a6

2-Oleamido-1,3-Octadecanediol

No Known Risks

A cosmetic functional ingredient used for conditioning, texture or formula support. Available cosmetic-use information did not identify a reproductive or developmental hazard from normal topical exposure.

Sources: European Commission CosIng ingredient inventory; relevant CIR cosmetic safety assessments and peer-reviewed cosmetic-use literature.

4-T-Butylcyclohexanol

No Known Risks

Acetyl Dipeptide-1 Cetyl Ester

No Known Risks

Synthetic acetylated peptide ester used in topical soothing, skin-conditioning and anti-aging cosmetic formulas. Available cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.

Sources: Schagen SK. Topical Peptide Treatments with Effective Anti-Aging Results. Cosmetics. 2017;4(2):16. doi:10.3390/cosmetics4020016; EU CosIng / INCI cosmetic ingredient references.

Adenosine

No Known Risks

Skin-conditioning ingredient commonly used in leave-on skincare. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Adenosine Ingredients as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Ceramide Np

No Known Risks

Skin-identical barrier lipid used to support the stratum corneum and reduce dryness. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Ceramides as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Hydroxypalmitoyl Sphinganine

No Known Risks

Lauroyl Lysine

No Known Risks

Amino-acid-derived conditioning and slip ingredient used especially in powders and colour cosmetics. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR: Safety Assessment of Amino Acid Alkyl Amides as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Octyldodecanol

No Known Risks

Fatty alcohol emollient used to improve spreadability and reduce drag. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR ingredient status / report data sheet for Octyldodecanol; EU CosIng / cosmetics regulatory inventory

Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate

No Known Risks

Antioxidant and stabilizer used to protect cosmetic formulas from oxidation. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical cosmetic use.

Sources: CIR cosmetic ingredient safety references for hindered phenolic antioxidants; EU CosIng / cosmetics regulatory inventory

Sodium Chloride

No Known Risks

Sodium chloride is used to adjust viscosity and texture in formulations; topical cosmetic use is considered low concern with no known pregnancy or breastfeeding risks.

Sources: CIR; EU/UK Cosmetics Regulation

Sodium Hyaluronate

No Known Risks

Sodium hyaluronate (hyaluronic acid salt) is used for hydration and cushioning, with very low systemic absorption from topical use and no known pregnancy or breastfeeding concerns at cosmetic concentrations.

Sources: CIR; EU/UK Cosmetics Regulation

Sodium Hydroxide

No Known Risks

pH adjuster used in very small quantities to balance formulations. Not associated with pregnancy-specific concerns.

Sources: Scientific Committee on Consumer Safety (EU); European cosmetics regulatory framework

Trisodium Ethylenediamine Disuccinate

No Known Risks

Chelating ingredient used to improve formula stability by binding trace metals. Reviewed cosmetic ingredient references do not identify a pregnancy- or breastfeeding-specific concern for normal topical use.

Sources: CIR cosmetic ingredient safety references for chelating agents; EU CosIng / cosmetics regulatory inventory

Tocopherol

No Known Risks

Vitamin E antioxidant used to protect oils and support the skin barrier. Not associated with pregnancy-specific concerns at cosmetic exposure.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Dicaprylyl Ether

No Known Risks

A lightweight fatty ether used as an emollient and spreading agent. Cosmetic safety reviewers concluded that dicaprylyl ether is safe in current cosmetic use; reviewed developmental testing did not identify maternal or fetal toxicity and skin absorption was low. Safety for airbrush delivery was not established.

Sources: CIR: Safety Assessment of Fatty Ethers https://www.cir-safety.org/sites/default/files/FR_FattyEthers_122022.pdf

Ammonium Polyacryloyldimethyl Taurate

No Known Risks

A high-molecular-weight polymer used to thicken and stabilise formulas. Cosmetic safety reviewers concluded that acryloyldimethyltaurate polymers are safe in current cosmetic practices. Absorption of the finished polymer is expected to be limited, with residual monomers controlled during manufacture.

Sources: CIR: Safety Assessment of Acryloyldimethyltaurate Polymers as Used in Cosmetics; final report April 2017 https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Behenyl Alcohol

No Known Risks

Long-chain fatty alcohol used as an emollient and thickener. This is not the same concern profile as simple drying alcohols; reviewed cosmetic safety sources support normal topical use.

Sources: CIR: Final Report on the Safety Assessment of Cetearyl Alcohol, Cetyl Alcohol, Isostearyl Alcohol, Myristyl Alcohol, and Behenyl Alcohol; EU CosIng / cosmetics regulatory inventory

Caprylyl Glycol

No Known Risks

Humectant and preservative booster used to support product stability. Low systemic exposure expected from topical cosmetic use.

Sources: Scientific Committee on Consumer Safety (EU); Cosmetic Ingredient Review (US)

Carbomer

No Known Risks

Polymer thickener used to create gel textures. Large-molecule ingredient with negligible systemic absorption.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Cetearyl Alcohol

No Known Risks

Fatty alcohol used as an emollient and thickener. Not the same as drying alcohols and not associated with pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US); Scientific Committee on Consumer Safety (EU)

Cetearyl Glucoside

No Known Risks

Sugar-based emulsifier used to stabilise creams and lotions. Reviewed cosmetic safety sources support topical cosmetic use; the relevant practical caveat is formulation irritation potential rather than a pregnancy-specific concern.

Sources: CIR: Decyl Glucoside and Other Alkyl Glucosides as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Glycine Soja Oil / Soybean Oil

No Known Risks

Helianthus Annuus Seed Oil / Sunflower Seed Oil

No Known Risks

Hydroxyethylcellulose

No Known Risks

Cellulose-derived thickener used to build viscosity and improve texture. Reviewed cosmetic safety sources support normal topical use, with no pregnancy- or breastfeeding-specific topical signal identified in the material reviewed.

Sources: CIR Quick Reference Table / ingredient status (Hydroxyethylcellulose, Final Report 03/2009); EU CosIng / cosmetics regulatory inventory

Lecithin

No Known Risks

Emulsifier and skin-conditioning ingredient composed of phospholipids. Not associated with pregnancy-specific concerns.

Sources: Cosmetic Ingredient Review (US)

Phenethyl Alcohol

No Known Risks

A fragrance component and preservative-support ingredient. Cosmetic safety reviewers concluded that phenethyl alcohol is safe in cosmetic products at concentrations up to 1%. It can still irritate or sensitise some users, but no pregnancy-specific concern was identified at reviewed cosmetic exposure.

Sources: CIR: Final Report on the Safety Assessment of Phenethyl Alcohol https://cir-reports.cir-safety.org/view-attachment/?id=e4ce160b-8e74-ec11-8943-0022482f06a6

Poloxamer 188

No Known Risks

Polycaprolactone

No Known Risks

Sorbitan Laurate

No Known Risks

A sorbitol-derived fatty-acid ester used as an emulsifier and texture agent. Cosmetic safety reviewers concluded that sorbitan fatty-acid esters, including sorbitan laurate, are safe in current practices of use and concentration. No pregnancy-specific concern was identified for normal topical exposure.

Sources: CIR: Final Report on the Safety Assessment of Sorbitan Fatty Acid Esters; CIR ingredient record and Quick Reference Table https://cir-safety.org/sites/default/files/QRT-Update-Dec2025.pdf

Steareth-100

No Known Risks

steareth-100 is a cosmetic formulation, mineral, sugar-derived or organic-acid ingredient. Available identity, use and related safety evidence did not identify a pregnancy-specific concern for normal topical cosmetic exposure. Cosmetic-grade purity and ordinary irritation precautions remain applicable.

Sources: CIR ingredient and related-family safety assessments; CIR Quick Reference Table https://www.cir-safety.org/supplementaldoc/quick-reference-table-december-2025; European Commission CosIng

Ci 40800 / Beta-Carotene

No Known Risks

Chlorphenesin

No Known Risks

Preservative used to help protect formulas from microbial growth. Reviewed cosmetic safety sources support present cosmetic use; no pregnancy- or breastfeeding-specific topical concern was identified in the material reviewed, although some users may still notice local irritation or sensitivity.

Sources: CIR: Safety Assessment of Chlorphenesin as Used in Cosmetics; EU CosIng / cosmetics regulatory inventory

Formulations can change without notice. For the most accurate result, compare this list with your packaging and scan the exact ingredient label in MamaSkin when you repurchase.

How to use this assessment

The risk band is the primary conclusion. The score adds detail within that band and should not be used to compare products as if a one-point difference were clinically meaningful.

MamaSkin provides pregnancy-focused information, not medical advice. Your midwife, GP, pharmacist or dermatologist should take priority when your circumstances differ from typical cosmetic use.

Read the full methodology